Scientist: Research Projects: Rabbit Mutation Database
The table below lists some of the rabbit craniofacial mutants.
The table gives information on the mutation by mutant abbreviation,
phenotype, and a brief description of the mutant phenotype.
| Abbreviation |
Phenotype |
Description |
| DOCSS
|
Delayed Onset Coronal Suture Synostosis
|
These rabbits exhibit patent coronal sutures at birth but the coronal suture growth rates are approximately 60% of normal. They also show postsynostotic, compensatory changes in the cranial vault and decreased intracranial volume. Their coronal sutures typically start to synostose by 42 days after birth and can occur either unilaterally or bilaterally. |
| EOCSS
|
Early Onset Coronal Suture Synostosis
|
These rabbits exhibit fused coronal sutures as early as 25 days of gestation (term = 31 days). They also exhibit severe secondary cranial vault deformities, hyperostotic calvarial bones, decreased intracranial volume, increased intracranial pressure, and significantly shorter and wider brains. Coronal suture synostosis can occur unilaterally or bilaterally. Postnatally, body weight, behavior, and postcranial skeletal growth are not affected in these rabbits. |
| IFSS
|
InterFrontal Suture Synostosis
|
These rabbits exhibit fused interfrontal (metopic) sutures as early as 25 days of gestation (term = 31 days). The other calvarial sutures are patent. They also exhibit severe cranial vault and brain deformities and hyperostotic frontal, ethmoidal, and sphenoidal bones. No rabbit with IFSS has survived more than fives days postnatally. Although the exact cause of death is not known, severe cerebellar and brain stem constriction has been observed. It has been suggested that these rabbits may represent the homozygote dominant condition |
| NCS
|
Normal Coronal Suture
|
These rabbits are phenotypically normal although they may be either: 1) heterozygous for the mutant gene with little or no expression, or; 2) genetically normal. Their coronal sutures are patent throughout their lifetime. |
Author: Dr. Mark Mooney
Content: 1998
Last checked: Oct 30,
2000
Last Updated:
9/9/03
|
