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Welcome to the laboratory of Dr. Valina Dawson in the
Institute of Cellular Engineering and the Departments of Neurology,
Neuroscience, and Physiology and the Graduate Program in Cellular and
Molecular Medicine at Johns Hopkins University.
Research in this laboratory is focused on discovering the molecular
signaling events leading to neuronal cell death and the molecules that
promote cell survival. The
ultimate goal of the laboratory is to identify new therapeutic targets
that have potential to be developed into novel treatments for patients
suffering from neurologic diseases.
The models we use to investigate these novel
signal cascades are largely focused on neurodegenerative diseases, stroke,
excitotoxicity, and ischemic preconditioning.
We also have projects on amyotrophic lateral sclerosis and triple
repeat disorders. To
investigate these mechanisms we apply a multidisciplinary approach using
primary tissue culture, molecular cloning strategies, differential gene
screening with array analysis, genetically engineered animals and protein
biochemistry strategies. My
laboratory works interactively with Ted M. Dawson’s laboratory, which
facilitates greater breadth in the scope of strategies we can employ to
unravel the process of neurotoxicity and neurodegeneration.
Please
visit the links to the left to learn more.
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