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Johns Hopkins University School of Medicine
Department of Cell Biology
725 N. Wolfe St., 114 WBSB
Baltimore, MD 21205
 

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Publications

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1.  Fambrough, D.M. and Devreotes, P.N.  1975.  Synthesis and degradation of acetylcholine receptors in cultured chick skeletal muscle.  In: Exploratory Concepts in Muscular dystrophy II. (A.T. Milhorat, ed.) Excerpta Medica, Amsterdam, pp. 55-67.

2.  Devreotes, P.N. and Fambrough, D.M.  1975.  Acetylcholine receptor turnover in membranes of developing muscle fibers.  J. Cell Biol. 65, 335-358.  (PDF version)

3.  Devreotes, P.N. and Fambrough, D.M.  1976.  Turnover of acetylcholine receptors in skeletal muscle.  In: Cold Spring Harbor Symposium on Quantitative Biology XL, 40, 237-251. 

4.  Fambrough, D.M. and Devreotes, P.N.  1976.  Development of chemical excitability in skeletal muscle.  In: Biogenesis and Turnover of Membrane Molecules (J. Cook, ed.) Raven Press, NY.

5.  Devreotes, P.N. and Fambrough, D.M.  1976.  Synthesis of acetylcholine receptors by cultured chick myotubes and denervated mouse extensor longus digiturum muscles.  Proc. Natl. Acad. Sci., USA 73, 161-164.  (PDF version)

6.  Devreotes, P.N.  1977.  Acetylcholine. In: McGraw-Hill Encyclopedia of Science and Technology (D. Lapides, ed.).

7.  Fambrough, D.M., Devreotes, P.N. and Card, D.J.  1977.  The synthesis and degradation of acetylcholine receptors. In: The Synapse (G.A. Cottrell, ed.) Blackie & Sons Ltd., Glasgow, pp. 203-237

8.  Fambrough, D.M. Devreotes, P.N., Card, D.J., Gardner, J. and Tepperman, K.  1977.  Metabolism of acetylcholine receptors in skeletal muscle.  National Cancer Institute Monograph 48, 277-294. (PDF version)

9.  Devreotes, P.N. Card, D.J., Tepperman, K.G. and Fambrough, D.M.  1977.  Studies on the metabolism of acetylcholine receptors in skeletal muscles.  In: Exploratory Concepts in Muscular Dystrophy III (I.P. Rowland, ed.).

10.  Devreotes, P.N., Gardner, J. and Fambrough, D.M.  1977.  Kinetics of biosynthesis of acetylcholine receptors and subsequent incorporation into plasma membranes of cultured skeletal muscle.  Cell 10, 365-373.

11.  Fambrough, D.M. and Devreotes, P.N.  1978.  Newly synthesized acetylcholine receptors are located in the Golgi.  J. Cell Biol. 76, 237-244.  (PDF version)

12.  Fambrough, D.M., Devreotes, P.N., Gardner, J.M. and Card, D.J.  1979.  The life history of acetylcholine receptors.  In: Progress in Brain Research (The Cholinergic Synapse) (S. Tucek, ed.) 49, 325-334. (PDF version)

13.  Devreotes, P.N.  1976.  Biosynthesis and degradation of acetylcholine receptors in developing embryonic myotubes. Ph.D. Thesis, Johns Hopkins University.

14.  Fambrough, D.M., Card-Linden, D., Devreotes, P.N., Gardner, J.M. and Rotundo, R.L.  1979.  On the regulation of the number and distribution of acetylcholine receptors in skeletal muscle. In: Nerve Cells, Transmitters and Behavior (R. Levi-Motaleni and C. Chagas, eds.) Elsevier Press.

15.  Devreotes, P.N., Derstine, P.L. and Steck, T.L.  1979.  Cyclic 3',5'-AMP relay in Dictyostelium discoideum.  I. A technique to monitor responses to controled stimuli.  J. Cell Biol. 80, 291-299.  (PDF version)

16.  Devreotes, P. and Steck, T.  1979.  Cyclic 3',5'-AMP relay in Dictyostelium discoideum.  II. Requirements for the initiation and termination of the response.  J. Cell Biol. 80, 300-309.  (PDF version)

17.  Dinauer, M.C., Mackay, S.A. and Devreotes, P.N.  1980.  Cyclic 3',5'-AMP relay in Dictyostelium discoideum.  III. The relationship of cAMP synthesis and secretion during the cAMP signaling response.  J. Cell Biol. 86, 537-544.  (PDF version)

18.  Dinauer, M.C., Steck. T.L. and Devreotes, P.N.  1980.  Cyclic 3',5'-AMP relay in Dictyostelium discoideum.  IV. Recovery of the cAMP signaling response after adaptation to cAMP.  J. Cell Biol. 86, 545-553.  (PDF version)

19.  Dinauer, M.C., Steck, T.L. and Devreotes, P.N.  1980.  Cyclic 3',5'-AMP relay in Dictyostelium discoideum.  V. Adaptation of the cAMP signaling response during cAMP stimulation.  J. Cell Biol. 86, 554-561.  (PDF version)

20.  Tomchik, K.J. and Devreotes, P.N.  1981.  Cyclic AMP waves in Dictyostelium discoideum: A demonstration by isotope dilution fluorography.  Science 212, 443-446. (COVER) (PDF version)

21.  Devreotes, P.N.  1982.  Chemotaxis.  In: The Development of Dictyostelium discoideum (W.F. Loomis, ed.) Academic Press, San Diego, Chap. 4, pp. 117-168.

22.  Devreotes, P.N.  1983.  Cyclic nucleotides and cell-cell communication in Dictyostelium discoideum.  Advances in Cyclic Nucleotide Research, Vol. 15, pp. 55-96.

23.  Devreotes, P.N.  1983.  The effect of folic acid on cAMP elicited cAMP production in Dictyostelium discoideum.  Develop. Biol. 95, 154-162.

24.  Devreotes, P.N., Potel, M.J. and Mackay, S.  1983.  Quantitative analysis of cAMP waves mediating aggregation in Dictyostelium discoideum.  Develop. Biol. 96, 405-415.

25.  Theibert, A. and Devreotes, P.N.  1983.  Cyclic 3',5'-AMP relay in Dictyostelium discoideum.  VI. Adaptation is independent of activation of adenylate cyclase.  J. Cell Biol. 97, 173-177.  (PDF version)

26.  Fontana, D. and Devreotes, P.  1984.  cAMP-stimulated adenylate cyclase activation in Dictyostelium is inhibited by agents acting at the cell surface.  Develop. Biol. 106, 76-82.

27.  Theibert, A. and Devreotes, P.  1984.  Adenosine and its derivatives inhibit the cyclic AMP signaling response in Dictyostelium.  Develop. Biol. 106, 166-173.

28.  Theibert, A., Klein, P. and Devreotes, P.  1984.  Specific photoaffinity labeling of the cAMP surface receptor in Dictyostelium.  J. Biol. Chem. 259, 12318-12321.  (PDF version)

29.  Fontana, D., Wong, T-Y., Theibert, A. and Devreotes, P.  1984.  Cell-cell interactions in the development of Dictyostelium.  In: The Cell Surface in Development and Cancer (M.S. Steinberg, ed.) Plenum.

30.  Chisholm, R., Fontana, D., Theibert, A., Lodish, H. and Devreotes, P.   1984.  The development of Dictyostelium discoideum: Chemotaxis, cell-cell adhesion, and gene expression.  In: Microbial Development (R. Losick and L. Shapiro, eds.) Cold Spring Harbor, NY, pp. 219-254. (PDF version)

31.  Klein, P., Theibert, A., Fontana, D. and Devreotes, P.  1984.  Identification and cyclic AMP-induced modification of the cyclic AMP receptor in Dictyostelium discoideum.  J. Biol. Chem. 260, 1757-1764.  (PDF version)

32.  Devreotes, P. and Sherring, J.  1985.  Kinetics and concentration dependence of reversible cAMP induced modification of the surface cAMP receptor in Dictyostelium.  J. Biol. Chem. 260, 6378-6384.  (PDF version)

33.  Klein, P., Fontana, D., Knox, B., Theibert, A., and Devreotes, P.  1985.  Cyclic AMP receptors controlling cell-cell interactions in the development of Dictyostelium.  In: Molecular Biology of Development, Cold Spring Harbor Symposium on Quantitative Biology, Vol. 50, pp. 787-799.

34.  Segel, L., Goldbeter, A., Devreotes, P. and Knox, B.  1986. A mechanism for exact sensory adaptation based on receptor modification.  J. Theor. Biol. 120, 151-179.

35.  Theibert, A., Palmisano, M., Jastorff, B. and Devreotes, P.  1985.  The specificity of the cAMP receptor mediating activation of adenylate cyclases in Dictyostelium discoideum.  Develop. Biol.  114, 529-533.

36.  Berlot, C., Spudich, J. and Devreotes, P.  1985.  Chemoattractant-elicited increases in myosin phosphorylation in Dictyostelium.  Cell 43, 307-314.

37.  Segel, L., Goldbeter, A., Devreotes, P. and Knox, B. 1985. A Mechanism for Exact Sensory Adaptation Based on Receptor Modification. In: Sensing and Response in Microorganisms (Proceeding of 13th Annual Aharon Katzir-Katchalsky Symposium, The Weizmann Institute, Rehovoth, Israel, March 17-22, 1985). (PDF version)

38.  Theibert, A., Fontana, D., Wong, T-Y. and Devreotes, P. 1985. Cell-cell interactions in the development of Dictyostelium. The American Zoologist 26, 549-551.

39.  Knox, B., Devreotes, P., Goldbeter, A. and Segel, L. 1986. A molecular mechanism for sensory adaptation based on ligand-induced receptor modification. Proc. Natl. Acad. Sci. USA 83, 2345-2349.  (PDF version)

40.  Theibert, A. and Devreotes, P. 1986. Surface receptor-mediated activation of adenylate cyclase in Dictyostelium: Regulation by guanine nucleotides in wild-type cells and aggregation deficient mutants. J. Biol. Chem. 261, 15121-15125.  (PDF version)

41.  Reymond, C., Gomer, R., Nellen, W., Theibert, A., Devreotes, P. and Firtel, R. 1986. phenotypic changes induced by a mutated ras gene during the development of Dictyostelium transformants. Nature 323, 340-343.

42.  Devreotes, P., Fontana, D., Klein, P., Sherring, J. and Theibert, A. 1987. Transmembrane signalling in Dictyostelium. Methods in Cell Biology 28, 299-331.

43.  Klein, P., Knox, B., Borleis, J. and Devreotes, P. 1987. Purification of the surface cAMP receptor in Dictyostelium. J. Biol. Chem. 262, 352-357.  (PDF version)

44.  Klein, P., Vaughan, R., Borleis, J. and Devreotes, P. 1987. The surface cyclic AMP receptor in Dictyostelium. J. Biol. Chem. 262, 358-364.  (PDF version)

45.  Vaughan, R., Pupillo, M., Theibert, A., Klein, P. and Devreotes, P. 1987. Surface receptor mediated activation and adaptation of adenylate cyclase in Dictyostelium. NATO Workshop on Receptor-Mediated Desensitization. In: Molecular Mechanisms of Desensitization to Signal Molecules, (T.M. Konijn, P.J.M. Van Haas, H. Van der Staue, H. Van der Wel, and M.D. Houslay, eds.) Springer-Verlag, Berlin, Series H: Cell Biology, Vol. 6, pp. 15-24.

46.  Berlot, C., Devreotes, P. and Spudich, J. 1987. Chemoattractant-elicited increases in Dictyostelium myosin phosphorylation are due to changes in myosin localization and increases in kinase activity. J. Biol. Chem. 262, 3918-3926.  (PDF version)

47.  Klein, P., Theibert, A. and Devreotes, P. 1988. Identification and ligand-induced modification of the cAMP receptor in Dictyostelium. Methods in Enzymology 159, 267-278.

48.  Berlot, C.H., Devreotes, P.N. and Spudich, J.A. 1988. Role of myosin phosphorylation in Dictyostelium chemotaxis. In: Signal Transduction in Cytoplasmic Organization and Cell Motility (Proceedings UCLA Conference, Lake Tahoe, CA) Alan R. Liss, Inc., pp. 287-292.

49.  Klein, P.S., Sun, T.L., Saxe, C.L. III, Kimmel, A.R., Johnson, R.L. and Devreotes, P.N. 1988. A chemoattractant receptor controls development in Dictyostelium discoideum. Science 241, 1467-1472. (PDF version)

50.  Saxe, C.L., Klein, P., Sun, T.J., Kimmel, A. and Devreotes, P. 1988. Structure and expression of the cAMP cell-surface receptor. Develop. Gen. 9, 227-233.

51.  Vaughan, R. and Devreotes, P. 1988. Ligand-induced phosphorylation of the cAMP receptor from Dictyostelium discoideum. J. Biol. Chem. 263, 14538-14543.  (PDF version)

52.  Pupillo, M., Klein, P., Vaughan, R., Pitt, G., Lilly, P., Sun, T., Devreotes, P., Kumagai, A. and Firtel, R. 1988. cAMP receptor and G-protein interactions control development in Dictyostelium. In: Molecular Biology of Signal Transduction, Cold Spring Harbor Symposium, Vol. 53, pp. 657-665.

53.  Kumagai, A., Mann, S., Pupillo, M., Pitt, G., Devreotes, P. and Firtel, R. 1988. A molecular analysis of G-proteins and control of early gene expression by the cell surface cAMP receptor in Dictyostelium. In: Molecular Biology of Signal Transduction, Cold Spring Harbor Symposium, Vol. 53, pp. 675-685.

54.  Devreotes, P.N. and Zigmond, S.H. 1988. Chemotaxis in eucaryotic cells: A focus on leukocytes and Dictyostelium. Ann. Rev. Cell Biol. 4, 649-686. (PDF version)

55.  Wang, M., Van Haastert, P.J.M., Devreotes, P. and Schaap, P. 1988. Localization of chemoattractant receptors on Dictyostelium discoideum cells during aggregation and down-regulation. Develop. Biol. 128, 72-77.

56.  Snaar-Jagalska, B.E., Devreotes, P.N. and Van Haastert, P.J.M. 1988. Ligand-induced modification of a surface cAMP receptor of Dictyostelium discoideum does not require its occupancy. J. Biol. Chem. 263, 897-901.  (PDF version)

57.  Pitt, G.S. and Devreotes, P.N. 1988. A simple BASIC program allows the rapid entry of DNA nucleotide sequences into personal computers. BioTechniques 6, 122-123.

58.  Lilly, P., Klein, P., Theibert, A., Vaughan, R., Pupillo, M., Saxe, C., Kimmel, A. and Devreotes, P. 1988. Receptor G-protein interactions in the development of Dictyostelium. Bot. Acta 101, 123-127.

59.  Gundersen, R.E., Johnson, R., Lilly, P., Pitt, G., Pupillo, M., Sun, T., Vaughan, R. and Devreotes, P.N. 1989. Reversible phosphorylation of G-protein-coupled receptors controls cAMP oscillations in Dictyostelium. In: Cell to Cell Signalling: From Experiments to Theoretical Models. (A. Goldbeter, ed.) Academic Press, London, pp. 477-486.

60.  Kumagai, A., Pupillo, M., Gundersen, R., Miaki-Lye, R., Devreotes, P. and Firtel, R. 1989. Regulation and function of Ga protein subunits in Dictyostelium. Cell 57, 265-275 (COVER) (PDF version)

61.  Pupillo, M., Kumagai, A., Pitt, G.S., Firtel, R.A. and Devreotes, P.N.  1989.  Multiple α-subunits of guanine nucleotide-binding proteins in Dictyostelium.  Proc. Natl. Acad. Sci. USA 86, 4892-4896.  (PDF version)

62.  Devreotes, P. 1989. Dictyostelium discoideum: A model system for cell-cell interactions in development. Science 245, 1054-1058.

63.  Devreotes, P. 1989. Cell-cell interactions in Dictyostelium development. TIGS 5, 242-245.

64.  Johnson, R.L., Gundersen, R., Lilly, P., Pitt, G., Pupillo, M., Sun, T.J., Vaughan, R.A. and Devreotes, P.N. 1989. G-protein-linked signal transduction systems control development in Dictyostelium. British Society of Developmental Biology, St. Andrews, Scotland. Development (Supplement) 107, 75?80.

65.  Vaughan, R., Johnson, R., Caterina, M. and Devreotes, P. 1989. Adaptation of chemoattractant elicited responses in Dictyostelium discoideum. NATO Conference on Sensing and Response, The Netherlands. In: Molecular Mechanisms of Desensitization to Signal Molecules (T.M. Konijn, et al., eds.) Springer-Verlag, Berlin, pp. 23-36.

66.  Firtel, R., Van Haastert, P., Kimmel, A. and Devreotes, P. 1989. G-protein linked signal transducing pathways in development: Dictyostelium as an experimental system. Cell (Minireview) 58, 235-239.

67.  Gundersen, R.E. and Devreotes, P.N. 1990. In vivo receptor-mediated phosphorylation of a G protein in Dictyostelium. Science 248, 591-593.

68.  Sun, T.J., Van Haastert, P.J.M. and Devreotes, P.N. 1990. Surface cAMP receptors mediate multiple responses during development in Dictyostelium: Evidenced by antisense mutagenesis. J. Cell Biol. 110, 1549-1554.  (PDF version)

69.  Pitt, G.S., Gundersen, R.E. and Devreotes, P.N. 1990. Mechanisms of excitation and adaptation in Dictyostelium. Seminars in Cell Biology 1, 99-104.

70.  Pitt, G.S., Gundersen, R.E., Lilly, P.J., Pupillo, M.B., Vaughan, R.A. and Devreotes, P.N. 1990. G protein-linked signal transduction in aggregating Dictyostelium. J. Gen. Physiology, Chap. 10, pp. 125-131.

71.  Saxe, III, C.L., Johnson, R.L., Devreotes, P.N. and Kimmel, A.R. 1991. Expression of a cAMP receptor gene of Dictyostelium and evidence for a multigene family. Genes & Development 5, 1-8.

72.  Saxe, C.L., Johnson, R., Devreotes, P.N. and Kimmel, A.R. 1991. Multiple genes for cell surface cAMP receptors in Dictyostelium discoideum. Developmental Genetics 12, 6-13.

73. Sun, T.J. and Devreotes, P.N. 1991. Gene targeting of the aggregation stage cAMP receptor cAR1 in Dictyostelium. Genes & Development 5, 572-582.

74.  Johnson, R.L., Vaughan, R.A., Caterina, M.J., Van Haastert, P.J.M. and Devreotes, P.N. 1991. Overexpression of the cAMP receptor 1 in growing Dictyostelium cells. Biochemistry 30, 6982-6986.  (PDF version)

75.  Caterina, M.J. and Devreotes, P.N. 1991. Molecular insights into eucaryotic chemotaxis. FASEB J. 5, 3078-3085.

76.  Wu, L. and Devreotes, P.N. 1991. Dictyostelium transiently expresses eight distinct G-protein a-subunits during its developmental program. Biochem. Biophys. Res. Commun. 179, 1141-1147.

77.  Johnson, R.L., Van Haastert, P.J.M., Kimmel, A.R., Saxe, C.L. III, Jastorff, B. and Devreotes, P.N. 1992. The cyclic nucleotide specificity of three cAMP receptors in Dictyostelium. J. Biol. Chem. 267, 4600-4607.  (PDF version)

78.  Pitt, G.S., Milona, N., Borleis, J., Lin, K.C., Reed, R.R. and Devreotes, P.N. 1992. Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyosteilum development. Cell 69, 305-315.

79.  Van Haastert, P.J.M., Wang, M., Bominaar, A.A., Devreotes, P.N. and Schaap, P. 1992. cAMP-induced desensitization of surface cAMP receptors in Dictyostelium: Different second messengers mediate receptor phosphorylation, loss of ligand binding, degradation of receptor, and reduction of receptor mRNA levels. Molec. Biol. of the Cell 3, 603-612.

80.  Hereld, D., and Devreotes, P.N. 1992. The cAMP receptor family of Dictyostelium. In: Molecular Biology of Receptors and Transporters: Receptors (M. Friedlander and M. Mueckler, eds.), Vol.137B of International Review of Cytology, Academic Press, Orlando, FL, pp. 35-47.

81.  Pupillo, M., Insall, R., Pitt, G.S. and Devreotes, P.N. 1992. Multiple cyclic AMP receptors are linked to adenylyl cyclase in Dictyostelium. Molec. Biol. of the Cell 3, 1229-1234.

82.  Johnson, R.L., Gundersen, R., Hereld, D., Pitt, G.S., Tugendreich, S., Saxe, C.L., Kimmel, A.R. and Devreotes, P.N. 1992. G-protein-linked signaling pathways mediate development in Dictyostelium. In: The Cell Surface, Vol. 57, Cold Spring Harbor Symp., Cold Spring Harbor Press, pp. 169-176.

83.  Wu, L., Gaskins, C., Gundersen, R., Hadwiger, J.A., Johnson, R.L., Pitt, G.S., Firtel, R.A. and Devreotes, P.N. 1993. Signal transduction by G-proteins in Dictyostelium discoideum. In: Handbook of Experimental Pharmacology, "GTPases in Biology II" (B. Dickey and L. Birnbaumer, eds.), Vol. 108, Springer-Verlag, pp. 335-349.

84.  Van Haastert, P.J.M. and Devreotes, P.N. 1993. Biochemistry and genetics of sensory transduction in Dictyostelium. In: Signal Transduction: Prokaryotic and Simple Eukaryotic Systems (J. Kurjan and B.L. Taylor, eds.), Academic Press (Review), Orlando, FL., pp. 329-352.

85.  Saxe, C.L. III, Ginsberg, G.T., Louis, J.M., Johnson, R., Devreotes, P.N. and Kimmel, A.R. 1993. cAR2, a prestalk cAMP receptor required for normal tip formation and late development of Dictyostelium discoideum. Genes & Development 7, 262-272. (COVER) (PDF version)

86.  Johnson, R., Saxe, C.L. III, Gollop, Kimmel, A.R. and Devreotes, P.N. 1993. Identification and targeted gene disruption of cAR3, a cAMP receptor subtype expressed during multicellular stages of Dictyostelium development. Genes & Development 7, 273-282. (PDF version)

87.  Milne, J. and Devreotes, P.N. 1993. The surface cyclic AMP receptors, cAR1, cAR2, and cAR3, promote Ca2+ influx in Dictyostelium discoideum by a Ga2-independent mechanism. Mol. Biol. of the Cell 4, 283-292. (PDF version)

88.  Lilly, P., Wu, L., Welker, D.L. and Devreotes, P.N. 1993. A G-protein b-subunit is essential for Dictyostelium development. Genes & Development 7, 986-995. (PDF version)

89.  Pitt, G.S., Brandt, R., Lin, K.C., Devreotes, P.N. and Schaap, P. 1993. Extracellular cAMP is sufficient to restore developmental gene expression and morphogenesis in Dictyostelium cells lacking the aggregation adenylyl cyclase (ACA). Genes & Development 7, 2172-2180.

90.  Caterina, M.J., Milne, J.L.S. and Devreotes, P.N. 1994. Mutation of the third intracellular loop of the cAMP receptor, cAR1, of Dictyostelium yields mutants impaired in multiple signaling pathways. J. Biol. Chem. 269, 1523-1532.  (PDF version)

91.  Devreotes, P.N. 1994. G-protein linked signaling pathways control the developmental program of Dictyostelium. Neuron 12, 1-20 (Minireview). (PDF version)

92.  Hereld, D., Vaughan, R., Kim, J-Y., Borleis, J. and Devreotes, P. 1994. Localization of ligand-induced phosphorylation sites to serine clusters in the C-terminal domain of the Dictyostelium cAMP receptor, cAR1. J. Biol. Chem. 269, 7036-7044.  (PDF version)

93.  Lilly, P. and Devreotes, P.N.  1994.  Identification of CRAC, a cytosolic protein required for guanine nucleotide stimulation of adenylyl cyclase in Dictyostelium.  J. Biol. Chem. 269, 14123-14129.  (PDF version)

94.  Wu, L., Gaskins, C., Zhou, K., Firtel, R.A. and Devreotes, P.N. 1994. Cloning and targeted mutations of Gα7 and Gα8, two developmentally regulated G protein a-subunit genes in Dictyostelium. Mol. Biol. of the Cell 5, 691-702.

95.  Insall, R.H., Soede, R.D.M., Schaap, P. and Devreotes, P.N. 1994. Two cAMP receptors activate common signalling pathways in Dictyostelium. Molec. Biol. of the Cell 5, 703-711.

96.  Insall, R., Kuspa, A., Lilly, P.J., Shaulsky, G., Levin, L.R., Loomis, W.F. and Devreotes, P.N. 1994. CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium. J. Cell Biol. 126, 1537-1545.  (PDF version)

97.  Soede, R.D.M., Insall, R.H., Devreotes, P.N. and Schaap, P. 1994. Extracellular cAMP can restore development in Dictyostelium cells lacking one, but not two, subtypes of early cAMP receptors (cARs). Development 120, 1997-2002. (PDF version)

98.  Chen, M.-Y., Devreotes, P.N. and Gundersen, R.E. 1994. Serine-113 is the site of receptor-mediated phosphorylation of the Dictyostelium G protein a-subunit, Ga2. J. Biol. Chem. 269, 20925-20930. (PDF version)

99.  Mann, S.K.O., Devreotes, P.N., Eliott, S., Jermyn, K., Kuspa, A., Fechheimer, M., Furukawa, R., Parent, C.A., Segall, J., Shaulsky, G., Vardy, P.H., Williams, J., Williams, K.L. and Firtel, R.A. 1994. Cell biological, molecular genetic, and biochemical methods to examine Dictyostelium. In: Cell Biology: A Laboratory Handbook, Vol. 1 (J.E. Celis, ed.) Academic Press, San Diego, pp. 412-451.

100.  Kim, J-Y and Devreotes, P.N. 1994. Random chimeragenesis of G-protein coupled receptors: mapping the affinity of the cAMP chemoattractant receptors in Dictyostelium. J. Biol. Chem. 269, 28724-28731. (PFD version)

101.  Caterina, M., Hereld, D. and Devreotes, P.N. 1995. Occupancy of the Dictyostelium cAMP receptor, cAR1, induces a reduction in affinity which depends upon COOH-terminal serine residues. J. Biol. Chem. 270, 4418-4423. (PDF version)

102.  Milne, J.L.S., Wu, L., Caterina, M.J. and Devreotes, P.N. 1995. Seven helix cAMP receptors stimulate Ca2+ entry in the absence of functional G proteins in Dictyostelium. J. Biol. Chem. 270, 5926-5931. (PDF version)

103.  Parent, C. and Devreotes, P.N. 1995. Molecular dissection of G protein-mediated signal transduction using random mutagenesis in Dictyostelium. Methods in Molecular Genetics (K.W. Adolph, ed.), Academic Press, Orlando, FL, pp. 3-15 (COVER). 

104.  Lilly, P. J. and Devreotes, P. N. 1995. Chemoattractant and GTPγS mediated stimulation of adenylyl cyclase in Dictyostelium requires translocation of CRAC to membranes. J. Cell Biol. 129, 1659-1665. 

105.  Wu, L., Valkema, R., Van Haastert, P. J. M. and Devreotes, P. N. 1995. The G-protein b-subunit is essential for multiple responses to chemoattractants in Dictyostelium. J. Cell Biol. 129, 1667-1675. 

106.  Caterina, M., Devreotes, P.N., Borleis, J. and Hereld, D. 1995. Agonist-induced loss of ligand binding is correlated with phosphorylation of cAR1, a G protein-coupled chemoattractant receptor from Dictyostelium. J. Biol. Chem. 270, 8667-8672. (PDF version)

107.  Parent, C.A. and Devreotes, P.N. 1995. Isolation of inactive and G protein-resistant adenylyl cyclase mutants using random mutagenesis. J. Biol. Chem. 270, 22693-22696. (PDF version)

108.  Chen, M.-Y., Insall, R.H. and Devreotes, P.N. 1996. Signaling through chemoattractant receptors in Dictyostelium. TIGS 12, 52-57. (COVER) (PDF version)

109.  Parent, C.A. and Devreotes, P.N. 1996. Molecular genetics of signal transduction in Dictyostelium. Annu. Rev. Biochem. 65, 411-440.

110.  Milne, J.L.S., Kim, J-Y. and Devreotes, P.N. 1996. Chemoattractant receptor signaling: G protein-dependent and -independent pathways. In: Signal Transduction in Health and Disease (J. Corbin and S. Francis, eds.), Raven Press. 

111.  Insall, R., Borleis, J. and Devreotes, P.N. 1996. The aimless RasGEF is required for processing of chemotactic signals through G-protein-coupled receptors in Dictyostelium. Current Biology 6, 719-729. (COVER) 

112.  Maeda, M., Aubry, L., Devreotes, P. and Firtel, R. 1996. Receptor mediated activation of a MAPK: Role of G proteins. J. Biol. Chem. 271, 3351-3354. (PDF version)

113.  Kim, J-Y. and Devreotes, P. 1996. Social senses: G-protein linked signaling pathways in Dictyostelium. Chemistry and Biology 3, 239-243. (COVER)

114.  Parent, C. and Devreotes, P.N. 1996. Constitutively active adenylyl cyclase mutant requires neither G proteins nor cytosolic regulators. J. Biol. Chem. 271, 18333-18336. (PDF version)

115. van Es, S., Virdy, K.J., Pitt, G.S., Meima, M., Sands, T.W., Devreotes, P.N., Cotter, D.A., Schaap, P. 1996 Adenylyl cyclase G, an osmosensor controlling germination of Dictyostelium spores. J Biol Chem 271(39):23623-5. (PDF version)

116.  Xiao, Z. and Devreotes, P.N. 1997. Identification of detergent-resistant plasma membrane microdomains in Dictyostelium: Enrichment of signal transduction proteins. Mol. Biol. Cell, 8, 855-869. 

117.  Milne, J.L.S., Caterina, M.J. and Devreotes, P.N. 1997. Random mutagenesis of the cAMP chemoattractant receptor, cAR1, of Dictyostelium: Evidence for multiple states of activation. J. Biol. Chem. 272, 2069-2076. (PDF version)

118.  Kim, J-Y., Caterina, M.J., Milne, J.L.S., Lin, K.C., Borleis, J.A. and Devreotes, P.N. 1997. Random mutagenesis of the chemoattractant receptor, cAR1 of Dictyostelium: Mutant classes that cause discrete shifts in agonist affinity and lock the receptor in a novel activational intermediate. J. Biol. Chem. 272, 2060-2068. (PDF version)

119.  Aubry, L., Maeda, M., Insall, R., Devreotes, P.N. and Firtel, R.A. 1997. The Dictyostelium mitogen-activated protein kinase ERK2 is regulated by Ras and cAMP-dependent protein kinase (PKA) and mediates PKA function. J. Biol. Chem. 272, 3883-3886. (PDF version)

120.  Zigmond, S.H., Joyce, M., Borleis, J., Bokoch, G.M. and Devreotes, P. 1997. Regulation of actin polymerization in cell-free systems by GTPgS and Cdc42. J. Cell Biol. 138, 363-374. (PDF version)

121.  Kim, J-Y., Soede, R.D.M., Schaap, P., Valkema, R., Borleis, J.A., Van Haastert, P.J.M., Devreotes, P.N. and Hereld, D. 1997. Phosphorylation of chemoattractant receptors is not essential for chemotaxis or termination of G-protein-mediated responses. J. Biol. Chem. 272, 27313-27318. (PDF version)

122.  Xiao, Z., Zhang, N., Murphy, D.B. and Devreotes, P.N. 1997. Dynamic distribution of chemoattractant receptors in living cells during chemotaxis and persistent stimulation. J. Cell Biol. 139, 365-374. (PDF version)

123.  Chen, M.-Y., Long, Y. and Devreotes, P.N. 1997. A novel cytosolic regulator, Pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the twelve transmembrane domain adenylyl cyclase in Dictyostelium. Genes and Development 11, 3218-3231. (PDF version)

124. Mann, K.O., Brown, J.M., Briscoe, C., Parent, C., Pitt, G., Devreotes, P.N., and Firtel, R.A. 1997 Role of cAMP-dpendent potein knase in controlling aggregation and postaggregative development in dictyostelium. Develop. Biol., 183, 208-221. (PDF version)

125.  Kim, J-Y., Borleis, J.A. and Devreotes, P.N. 1998. Switching of chemoattractant receptors programs development and morphogenesis in Dictyostelium: Receptor subtypes activate common responses at different agonist concentrations. Develop. Biol., 197, 117-128. (PDF version)

126.  Jin, T., Soede, R., Liu, J., Kimmel, A., Devreotes, P.N. and Schaap, P. 1998. Temperature-sensitive Gb mutants discriminate between G protein-dependent and -independent signaling mediated by serpentine receptors. EMBO J., 17, 5076-5084. (PDF version)

127. Peracino, B., Borleis, J., Jin, T., Westphal, M., Schwartz, J-M., Wu, L., Bracco, E., Gerisch, G., Devreotes, P.N., and Bozarro, S. 1998. G protein ß-subunit-null mutants are impaired in phagocytosis and chemotaxis due to inappropriate regulation of the actin cytoskeleton. J. Cell Biol., 141, 1529-1537. (PDF version)

128.  Verkerke-Van Wijk, I., Kim, J-Y., Brandt, R., Devreotes, P.N. and Schaap, P. 1998. Functional promiscuity of gene regulation by serpentine receptors in Dictyostelium discoideum.  Mol. Cell. Biol. 18, 5744-5749. (PDF version)

129.  Jin, T., Amzel, M., Devreotes, P.N. and Wu, C 1998. Selection of Gb subunits with point mutations that fail to activate specific signaling pathways in vivo: dissecting cellular responses mediated by a heterotrimeric G-protein in Dictyostelium discoideum. Mol. Biol. Cell. 9, 2949-2961. (PFD version)

130.  Parent, C., Blacklock, B., Froelich, W., Murphy, D. and Devreotes, P.N. 1998. G protein signaling events are activated at the leading edge of chemotactic cells. Cell, 95, 81-91. (PFD version)

131.  Xiao, Z., Yao, Y., Long, Y. and Devreotes, P.N. 1999. Desensitization of G-protein-coupled Receptor - agonist-induced phosphorylation of the chemottractant receptor for cAR1 lowers its intrinsic affinity for cAMP. J. Biol. Chem, 274, 1440-1448. (PFD version)

132.  Vithalani, K.K., Parent, C.A., Thorn, E.M., Penn, M., Larochelle, D.A., Devreotes, P.N., and De Lozanne, A. 1999. Identification of Darlin, a Dictyostelium Protein with Armadillo-like Repeats that Binds to Small GTPases and Is Important for the Proper Aggregation of Developing Cells Mol. Biol. Cell, 9, 3095-3106. (PDF version)

133.  van Es, S. and Devreotes, P.N. 1999. Molecular Basis of Localized Signal Responses during Chemotaxis in Amoebae and Leukocytes. Cellular and Molecular Life Science, 55, 1341-1351. (PDF version)

134.  Parent, C. and Devreotes, P.N. 1999. A Cell's Sense of Direction. Science, 284, 765-770. (PDF version)

135.  Parent, C., Xiao, Z., Zhang, N., and Devreotes, P. N. 1999. "Chemotaxis in Eucaryotic Cell" in GFP in Motion (CD edited by Beat Ludin).

136. Devreotes, P. N. and International D. discoideum Organizing Committee. 1999. "D. discoideum: Model System in Motion". Promotional Web Site for Dictyostelium <www.hopkinsmedicine.org/dictyostelium>.

137.  Jin, T., Zhang, N., Long, Y., Parent, C., and Devreotes, P.N. 2000. Localization of the G protein bg complex in living cells during chemotaxis. Science, 287, 1034-1036. (PDF version)

138.  Garcia, M.X., Foote, C., van Es, S., Devreotes, P.N., Alexander, S., Alexander, H. 2000. Differential developmental expression and cell type specificity of dictyostelium catalases and their response to oxidative stress and UV-light. Biochim Biophys Acta., 1492, 295-310. (PDF version)

139.  Patel, H., Guo, K., Parent, C., Gross, J., Devreotes, P.N., Weijer, C.J. 2000. A temperature-sensitive adenylyl cyclase mutant of Dictyostelium. EMBO J., 19, 2247-56. (PDF version)

140.  van Es, S., Wessels, D., Soll, D., Borleis, J., and Devreotes, P.N. 2001 Tortoise, a novel mitochondrial protein, is required for directional responses of dictyostelium in chemotactic gradients. J. Cell Biol., 152(3), 621-632. (PDF version)

141.  Janetopoulos, C., Jin, T. and Devreotes, P.N. 2001. Receptor mediated activation of heterotrimeric G-proteins in living cells. Science, 291, 2408-2411. (PDF version)

142.  Briscoe, C., Moniakis, J., Kim, J-Y., Brown, J., Hereld, D., Devreotes, P.N., and Firtel, R. (2001) The phosphorylated C-terminus of cAR1 plays a role in cell-type-specific gene expression and STATa tyrosine phosphorylation. Dev. Biol., 233, 225-236. (PDF version)

143.  Weiner, O.D., Servant, G., Parent, C.A., Devreotes, P.N., and Bourne, H.R. (2000) Cell polarity in response to chemoattractants, in Cell polarity (Drubin, D.G., ed). Frontiers in Molecular Biology (B.D. Hames and D.M. Glover, eds.) Oxford University Press, pp. 201-239. 

144.  van Es, S., Weenings, K.E., and Devreotes, P.N. (2001) The protein kinase YakA regulates G-protein-linked signaling responses during growth and development of Dictyostelium. J Biol Chem, 276(33), 30761-30765. (PDF version)

145. Verkerke-van Wijk, I., Adrian, I., Devreotes, P.N., and Schaap, P. 2001 Adenylyl cyclase A expression is tip-specific in Dictyostelium slugs and directs StatA nuclear translocation and CudA gene expression. Dev. Biol. 234(1), 151-60. (PDF version)

146.  Dormann, D., Kim, J-Y., Devreotes, P.N., and Weijer, C.J. 2001 cAMP receptor affinity controls wave dynamics, geometry and morphogenesis in Dictyostelium. J Cell Science 114, 2513-2523. (PDF version)

147.  Zhang, N, Long, Y. and Devreotes, P.N. 2001 Gg in Dictyostelium: Its role in localization of Gbg to the membrane is required for chemotaxis in shallow gradients. Mol Bio Cell. 12(10), 3204-13. (PDF version)

148.  Parent, C., Borleis, J., and Devreotes, P.N. 2001 Regulation of adenylyl cyclases by a region outside the minimally functional cytoplasmic domains. J. Biol. Chem. 277(2), 1354-1360. (PDF version)

149.  Ueda, M., Sako, Y., Tanaka, T., Devreotes, P., and Yanagida, T. 2001 Single molecule analysis of chemotactic signaling in Dictyostelium cells. Science, 294(5543), 864-7. (PDF version)

150.  Bankir, L., Ahloulay, M., Devreotes, P.N., and Parent, C.A. 2002 Extracellular cAMP inhibits proximal reabsorption: are plasma membrane cAMP receptors involved? Am J Physiol Renal Physiol. 282(3):F376-92. Review. (PDF version)

151.  Zhao, M., Jin, T., McCaig, C., Forrester, J., and Devreotes, P.N. 2002 Genetic analysis of the role of G protein-coupled receptor signaling in electrotaxis. J. Cell Bio. 157(6), 921-927. (PDF version)

152.  Janetopoulos, C. and Devreotes, P.N. 2002 Monitoring receptor-mediated activation of heterotrimeric G-proteins by fluorescence resonance energy transfer. Methods for the Study of Receptor-Receptor Interactions. (Yogesh C. Patel, ed.), Academic Press, San Diego, CA. Methods 27, 366-373. 

153.  Iijima, M. and Devreotes, P. N. 2002 Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell 109, 599-610 (Cover). (PDF version)

154.  Zhang, N., Long, Y., and Devreotes, P.N. 2002 Ege A, a novel C2 domain containing protein, is essential for GPCR-mediated gene expression in Dictyostelium. Dev. Bio. 248, 1-12. (PDF version)

155.  Dormann, D., Weijer, G., Parent, C.A., Devreotes, P.N., and Weijer, C.J. 2002 Visualizing PI3 kinase-mediated cell-cell signaling during Dictyostelium development. Curr. Bio. 12, 1178-1188. (PDF version)

156.  Iijima, M., Huang, E., and Devreotes, P.N. 2002 Temporal and spatial regulation of chemotaxis. Dev. Cell 3, 469-478. (PDF version)

157.  Pergolizzi, B., Peracino, B., Silverman, J., Ceccarelli, A., Noegel, A., Devreotes, P.N., and Bozzaro, S.  2002  Temperature-sensitive inhibition of development in Dictyostelium due to a point mutation in the piaA gene.  Dev. Biol. 251, 18-27. (PDF version)

158.  Gilman, A.G., Devreotes, P.N., et al.  2002  Overview of the Alliance for Cellular Signaling.  Nature 420, 703-706.

159.  Huang, E., Iijima, M., Funamoto, S., Firtel, R., and Devreotes, P.N. 2003 Receptor-mediated Regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells.  Mol. Biol. Cell 14, 1913-1922. (PDF version)

160.  Janetopoulos, C. and Devreotes, P.N. 2003 Eukaryotic Chemotaxis:  Distinctions between directional sensing and polarization.  J. Biol. Chem.  278, 20445-20448. (PDF version)

 161.  Landree, M.A. and Devreotes, P.N.  2003  Analyzing chemotaxis using Dictyostelium discoideum as a model system.  In:  Cell Migration in Inflammation and Immunity (D. D'Ambrosio and F. Sinigaglia, eds.).  Humana Press, Totowa, NJ. Methods in Molecular Biology 239:91-104.

162.  Luo, H.R., Huang, Y.E., Chen, J.C., Saiardi, A., Iijima, M., Ye, K., Huang, Y., Nagata, E., Devreotes, P.N., and Snyder, S.H.  2003  Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions.  Cell 114(5), 559-572. (PDF version)

163.  Chen, L., Janetopoulos, C., Huang, Y.E., Iijma, M., Borleis, J., and Devreotes, P.N.  2003  Two phases of actin polymerization display different dependences on PI(3,4,5)P3 accumulation and have unique roles during chemotaxis.  Mol. Biol. Cell 14(12):5028-5037. (PDF version)

164.  Manahan, C.L. and Devreotes, P.N.  2003  βγ signaling in chemotaxis.  In: Handbook of Cell Signaling (R. Bradshaw and E. Dennis, eds.).  Academic Press, San Diego, CA, Vol. 2, Chapter 227, pp. 645-649.

165.   Kutscher, B., Devreotes, P.N., and Iglesias, P.A.  2004  Local excitation, global inhibition mechanism for gradient sensing:  An interactive applet.  Sci STKE 219:13.

166.  Iijima, M., Huang, Y.E., Luo, H.R., Vazquez, F., and Devreotes, P.N.  2004  Novel mechanism of PTEN regulation by its Phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis.  J. Chem. 279(16):16606-16613. (PDF version)

167.  Hereld, D. and Devreotes, P.N.  Cyclic AMP Receptors of Dictyostelium.  2004  Encyclopedia of Biological Chemistry.  (W.J. Lennarz and M.D. Lane, eds.), Elsevier, Oxford, Vol. 1, pp. 488-493. (PDF version)

168.  Montell, C. and Devreotes, P.N.  2004  Annual Review on Cell Regulation - From protein dynamics to animal behavior:  new insights into complex cell regulatory mechanisms.  Curr. Opin. Cell Biol. 16:115-118. (PDF version)

169.  Janetopoulos, C., Ma, L., Iglesias, P.A., and Devreotes, P.N.  2004  Chemoattractant-induced temporal and spatial PI(3,4,5)P3 accumulation is controlled by a local excitation, global inhibition mechanism.  PNAS 101(24):8951-8956. (PDF version)

170.  Hynes, T.R., Tang, L., Mervine, S.M., Sabo, J.L., Yost, E.A., Devreotes, P.N., and Berlot, C.H.  2004  Visualization of G-protein βγ dimers using bimolecular fluorescence complementation demonstrates roles for both β and γ in subcellular targeting.  J. Biol. Chem. 279(29):30279-30286. (PDF version)

171.  Van Haastert, P.J. and Devreotes, P.N.  2004  Chemotaxis: signaling the way forward. Nat. Mol. Cell Biol. 5(8):626-634. (PDF version)

172.  Franca-Koh, J. and Devreotes, P.N.  2004  Moving forward: mechanisms of chemoattractant gradient sensing. Physiology 19:300-308.  (PDF version)

173.  Manahan, C., Iglesias, P., and Devreotes, P.N.  2004  Chemoattractant signaling in Dictyostelium discoideum. Annu. Rev. Cell Dev. Biol. 20:223-253. (PDF version)

174.  Ma, L., Janetopoulos, C., Yang, L., Devreotes, P.N., Iglesias, P.A.  2004  Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P3 response in Dictyostelium cells.  Biophys J. 87:3764-3774. (PDF version)

175.  Janetopoulos, C., Long, Y., and Devreotes, P.N.  2005  Mechanisms of Eukaryotic Chemotaxis.  In: Cell Migration in Development and Disease (D. Wedlich, ed.). Wiley-VCH Publications, Chapter 3, pp. 33-45.

176.  Janetopoulos, C., Borleis, J., Vazquez, F., Iijima, M., and Devreotes, P.N.  2005  Temporal and spatial regulation of phosphoinositide signaling mediates cytokinesis.  Dev. Cell 8:467-477. (PDF version)

177.  Fache, S., Dalous, J., Engelund, M., Hansen, C., Chamaraux, F., Fourcade, B., Satre, M., Devreotes, P., and Bruckert, F.  2005  Calcium mobilization stimulates Dictyostelium discoideum shear-flow-induced cell motility.  J Cell Sci 118:3445-3457. (PDF version)

178.  Matsuoka, S., Ueda, M., Watanabe, T., Kuwayama, H., Devreotes, P.N., and Yanagida, T.   2005 Single-molecule analysis of chemoattractant-stimulated membrane recruitment of a PH-domain-containing protein. J Cell Sci 119:1071-1079. (PDF version)

179.  Vazquez, F., Matsuoka, S., Sellers, W.R., Yanagida, T., Ueda, M., and Devreotes, P.N.  Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane.  PNAS 103:3633-3638. (PDF version)

180.  Loovers, H.M., Postma, M., Keizer-Gunnink, I., Huang, Y.E., Devreotes, P.N., and van Haastert, P.J.M.  2006  Distinct roles of PI(3,4,5)P3 during chemoattractant signaling in Dictyostelium:  A quantitative in vivo analysis by inhibition of PI3-kinase.  Mol Biol Cell 17:1503-1513. (PDF version)

181.  Franca-Koh, J., Kamimura, Y., Devreotes, P.N.  2006  Chemotaxis and Dictyostelium.  Special issue on Cell Mobility and Morphogenesis in Development, section: Pattern Formation and Developmental Mechanisms.  Curr. Opin. Gen. Dev. 16:333-338. (PDF version)

182.  Vazquez, F. and Devreotes, P.N.  2006  Regulation of PTEN function as PIP3 gatekeeper through membrane interaction.  Cell Cycle 5:1523-1527. (PDF version)

183.  Zhao, M., Song, B., Pu, J., Wada, T., Reid, B., Tai, G., Wang, F., Guo, A., Walczysko, P., Sasaki, T., Suzuki, A., Forrester, J.V., Bourne, H.R., Devreotes, P.N., McCaig, C.D., and Penninger, J.M.  2006  Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN.  Nature 442:457-460. (PDF version)

184.  Janetopoulos, C. and Devreotes, P.N.  Phosphoinositide signaling plays a key role in cytokinesis.  Minireview. J. Cell Biol. 174:485-490. (PDF version)

185.  Willard, S. and Devreotes, P.N. Signaling pathways mediating chemotaxis in the social amoebae, Dictyostelium discoideum.  2006  Eur. J. Cell Biol, 85:897-904. (PDF version)

186.  Somesh, B.P., Neffgen, C., Iijima, M., Devreotes, P.N., and Rivero-Crespo, F.R.  2006  Dictyostelium RacH regulates endocytic vesicular trafficking and is required for localization of vacuolin. Traffic 7:1194-1212. (PDF version)

187.  Somesh, B.P., Vlahou, G., Iijima, M., Insall, R.H., Devreotes, P., and Rivero-Crespo, F.R.  2006  RacG regulates morphology, phagocytosis and chemotaxis.  Eukaryotic Cell 5:1648-1663. (PDF version)

188.  Franca-Koh, J., Kamimura, Y., and Devreotes, P.N.  2006  Leading-edge research: PtdIns(3,4,5)P3 and directed migration.  Nat. Cell Biol. 9:15-17. (PDF version)

189.  Chen, L., Iijima, M., Tang, M., Landree, M.A., Huang, Y.E., Xiong, Y., Iglesias, P.A., and Devreotes, P.N.  2007  PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis.  Dev. Cell 12(4):603-614. (PDF version)

190.  Sasaki, A.T., Janetopoulos, C., Lee, S., Charest, P.G., Takeda, K., Sundheimer, L.W., Meili, R., Devreotes, P.N., and Firtel, R.A.  2007 G protein-independent Ras/PI3K/F-actin circuit regulates basis cell motility.  J. Cell Bio. 178(2):185-191. (PDF version)

191.  Iglesias, P.A. and Devreotes, P.N.  2007  Navigating through models of chemotaxis.  Curr. Opin. Cell Bio., 20(1):25-40. (PDF version)

192.  Kamimura, Y. , Xiong, Y., Iglesias, P.A., Hoeler, O., Bolourani, P., and Devreotes, P.N.  2008 PIP(3)-Independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis.  Curr. Bio. 18:1034-43. (PDF version)

193.  Tang, L., Franca-Koh, J., Xiong, Y., Chen, M-Y., Long, Y., Bickford, R.M., Knecht, D.A., Iglesias, P.A., and Devreotes, P.N.  2007 Tsunami, the Dictyostelium homolog of the Fused kinase is required for polarization and chemotaxis.  Genes Dev 22:2278-2290. (PDF version)

194.  Rahdar, M., Inoue, T., Meyer T., Zhang, J., Vazquez, F., Devreotes, P.N.  2009  A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.  PNAS 106:480-485.  (PDF version)

195.  Kamimura, Y., Tang, M., and Devreotes, P.N.  2009  Assays for Chemotaxis and Chemoattractant-Stimulated TorC2 Activation and PKB Substrate Phosphorylation in Dictyostelium.  In: Chemotaxis, Methods in Molecular Biology, vol. 571. (D. Hereld, T. Jin, eds.). Humana Press. (PDF version)

196.  Franca-Koh, J., Willard, S.S., and Devreotes, P.N. 2009 G-Protein Signaling in Chemotaxis.  In: Ralph A. Bradshaw and Edward A. Dennis, editors, Handbook of Cell Signaling 2nd edition.  Oxford: Academic Press, pp. 1705-1712. (PDF version)

197. Kamimura, Y., and Devreotes, P.N.  2010 Phosphoinositide-dependent protein kinase (PDK) activity regulates phosphatidylinositol 3,4,5-trisphosphate-dependent and -independent protein kinase B activation and chemotaxis.  J. Biol. Chem. 285(11):7938-7946. (PDF version)

198. Swaney, K.F., Huang, C.H., Devreotes, P.N. 2010 Eukaryotic Chemotaxis: A network of signaling pathways controls motility, directional sensing, and polarity.  Annu. Rev. Biophys. 278:20445-20448. (PDF version)

199. Xiong, Y., Kabacoff, C., Franca-Koh, J., Devreotes, P.N., Robinson, D.N., and Iglesias, P.A. 2010 Automated characterization of cell shape changes during amoeboid motility by skeletonization.  BMC Syst. Biol., 4:33. (PDF version)

200. Cai, H., Das, S., Kamimura, Y., Comer, F.I., Parent, D.A., and Devreotes, P.N.  2010  Ras-mediated activation and inactivation of the TorC2-PKB pathway are critical for chemotaxis.  J. Cell Biol, 190:233-245. (PDF version)

201. Xiong, Y., Huang, C-H, Iglesias, P.A., and Devreotes, P.N.  2010  Cells navigate with a local-excitation, global-inhibition-biased excitable network. PNAS 107:17079-17086. (PDF version)

202.  Kamimura, Y., Cai, H., Tang, M., and Devreotes, P.N.  2010  TorC2 and chemotaxis in Dictyostelium discoideum.  In: The Enzymes (Michael N. Hall and Fuyuhiko Tamanoi, eds.). Academic Press, Volume 28, pp. 125-142. (PDF version)

203.  QnAs with Peter N. Devreotes.  2010.  Interview by Prashant Nair.  PNAS, Nov. 16;107:19613. (PDF version)

204.  Tang, M., Iijima, M., Kamimura, Y., and Devreotes, P.N.  2011  Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN.  Mol. Biol. Cell, 22:437-447. (PDF version)

205.  de Keijzer, S., Galloway, J., Devreotes, P.N., and Iglesias, P.A.  2011 Disrupting microtubule network immobilizes amoeboid chemotactic receptor in the plasma membrane.  Biochimica et Biophysica Acta, 1808:1701-1708. (PDF version)

206.  Artemenko, Y., Swaney, K., and Devreotes, P.N.  2011  Assessment of development and chemotaxis in Dictyostelium discoideum mutants.  Meth. Mol. Biol. 769:287-309. (PDF version)

207.  Gao, R.C., Zhang X.D., Sun, Y.H., Kamimura, Y., Mogilner, A., Devreotes, P.N., and Zhao, M.  2011  Different roles of membrane potentials in elecrotaxis and chemotaxis of Dictyostelium cells.  Eukaryot Cell, 10:1251-1256. (PDF version)

208.  Tang, M., Iijima, M., and Devreotes, P.N.  2011  Generation of cells that ignore the effects of PIP3 on cytoskeleton.  Cell Cycle, 10(17). (PDF version)

209.  Cai, H. and Devreotes, P.N.  2011  Moving in the right direction:  How eukaryotic cells migrate along chemical gradients.  Semin. Cell Dev. Biol. 22:834-841. (PDF version)

210.  Cai, H., Huang, C.H., Devreotes, P.N., and Iijima, M.  2011  Analysis of chemotaxis in dictyostelium.  Methods Mol. Biol., 757:451-468. (PDF version)

211.  Iglesias, P.A. and Devreotes, P.N. 2012 Biased excitable networks: how cells direct motion in response to gradients. Curr. Opin. Cell. Biol., 757:451-468. (PDF version)

212. Galloway, J.F., Winter, A., Lee, K.H., Park, J., Dvoracek, C., Devreotes, P.N., and Searson, P.C. 2011 Quantitative characterization of the lipid encapsulation of quantum dots for biomedical applications. Nanomedicine, 8:1190-1199.

213.  Artemenko, Y., Batsios, P., Borleis, J., Gagnon, Z., Lee, J., Rohlfs, M., Sansťau, D., Willard, S.S., Schleicher, M., and Devreotes, P.N.  Tumor suppressor Hippo/MST1 kinase mediates chemotaxis by regulating spreading and adhesion. PNAS 2012;109(34):13632-13637.

 

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