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Johns Hopkins University School of Medicine
Department of Cell Biology
725 N. Wolfe St., 114 WBSB
Baltimore, MD 21205

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Andrew N, Insall RH. 2007. Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions. Nat. Cell Biol. 9:193-200. (pdf)


Blaser H, Reichman-Fried M, Castanon I, Dumstrei K, Marlow FL, et al. 2006. Migration of zebrafish primordial germ cells: a role for myosin contraction and cytoplasmic flow. Dev. Cell 11:613-627. (pdf)


Bosgraaf L, van Haastert PJ. 2009. The ordered extension of pseudopodia by amoeboid cells in the absence of external cues. PLoS One 4:e5253. (pdf)


Bretschneider T, Jonkman J, Kohler J, Medalia O, Barisic K, et al. 2002. Dynamic organization of the actin system in the motile cells of Dictyostelium. J. Muscle Res. Cell Motil. 23:639-649. (pdf)


Chen L, Iijima M, Tang M, Landree MA, Huang YE, et al. 2007. PLA2 and PI3KPTEN pathways act in parallel to mediate chemotaxis. Dev. Cell 12:603-614. (pdf)


Chen L, Janetopoulos C, Huang YE, Iijima M, Borleis J, Devreotes PN. 2003. Two phases of actin polymerization display different dependencies on PI(3,4,5)P3 accumulation and have unique roles during chemotaxis. Mol. Biol. Cell 14:5028-5037. (pdf)


Chen MY, Long Y, Devreotes PN. 1997. A novel cytosolic regulator, Pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium. Genes. Dev. 11:3218-3231. (pdf)


Chung CY, Potikyan G, Firtel RA. 2001. Control of cell polarity and chemotaxis by AktPKB and PI3 kinase through the regulation of PAKa. Mol. Cell 7:937-947. (pdf)


Clarke M, Muller-Taubenberger A, Anderson KI, Engel U, Gerisch G. 2006. Mechanically induced actin-mediated rocketing of phagosomes. Mol. Biol. Cell 17:4866-75. (pdf)


Devreotes P, Janetopoulos C. 2003. Eukaryotic chemotaxis: distinctions between directional sensing and polarization. J. Biol. Chem. 278:20445-48. (pdf)


Dormann D, Weijer G, Dowler S, Weijer CJ. 2004. In vivo analysis of 3-phosphoinositide dynamics during Dictyostelium phagocytosis and chemotaxis. J. Cell Sci. 117:6497ó509. (pdf)


Ferguson GJ, Milne L, Kulkarni S, Sasaki T, Walker S, et al. 2007. PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis. Nat. Cell Biol. 9:86-91. (pdf)


Hoeller O, Kay RR. 2007. Chemotaxis in the absence of PIP3 gradients. Curr. Biol. 17:81317. (pdf)


Iglesias PA, Devreotes PN. 2008. Navigating through models of chemotaxis. Curr. Opin. Cell Biol. 20:35-40. (pdf)


Inoue T, Meyer T. 2008. Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration. PLoS ONE 3:e3068. (pdf)


Janetopoulos C, Borleis J, Vazquez F, Iijima M, Devreotes P. 2005. Temporal and spatial regulation of phosphoinositide signaling mediates cytokinesis. Dev. Cell 8:467-477. (pdf)


Kamimura Y, Xiong Y, Iglesias PA, Hoeller O, Bolourani P, Devreotes PN. 2008. PIP3-independent activation of TorC2 and PKB at the cellís leading edge mediates chemotaxis. Curr. Biol. 18:1034-1043. (pdf)


Meinhardt H. 1999. Orientation of chemotactic cells and growth cones: models and mechanisms. J. Cell Sci. 112(Pt. 17):2867-2874. (pdf)


Mortimer D, Fothergill T, Pujic Z, Richards LJ, Goodhill GJ.  2007  Growth cone chemotaxis. Trends Neurosci 31:90-98. (pdf)


Parent CA, Blacklock BJ, Froehlich WM, Murphy DB, Devreotes PN. 1998. G protein signaling events are activated at the leading edge of chemotactic cells. Cell 95:81-91. (pdf)


Parent CA, Devreotes PN. 1999. A cellís sense of direction. Science 284:765-770. (pdf)


Rehberg M, Kleylein-Sohn J, Faix J, Ho TH, Schulz I, Graf R. 2005. Dictyostelium LIS1 is a centrosomal protein required for microtubulecell cortex interactions, nucleuscentrosome linkage, and actin dynamics. Mol. Biol. Cell 16:2759-2771. (pdf)


Schneider IC, Haugh JM. 2006. Mechanisms of gradient sensing and chemotaxis: conserved pathways, diverse regulation. Cell Cycle 5:1130-1134. (pdf)


Tang L, Franca-Koh J, Xiong Y, Chen MY, Long Y, et al. 2008. tsunami, the Dictyostelium homolog of the Fused kinase, is required for polarization and chemotaxis. Genes. Dev. 22:2278-2290. (pdf)


Ueda M, Sako Y, Tanaka T, Devreotes P, Yanagida T. 2001. Single-molecule analysis of chemotactic signaling in Dictyostelium cells. Science 294:864-867. (pdf)


van Haastert PJ, Kuwayama H. 1997. cGMP as second messenger during Dictyostelium chemotaxis. FEBS Lett. 410:25-28. (pdf)


von Philipsborn A, Bastmeyer M. 2007. Mechanisms of gradient detection: a comparison of axon pathfinding with eukaryotic cell migration. Int. Rev. Cytol. 263:1-62. (pdf)


Wadhams GH, Armitage JP. 2004. Making sense of it all: bacterial chemotaxis. Nat. Rev. Mol. Cell Biol. 5:1024-1037. (pdf)


Weiner OD, Marganski WA, Wu LF, Altschuler SJ, Kirschner MW. 2007. An actin-based wave generator organizes cell motility. PLoS Biol. 5:e221. (pdf)


Weiner OD, Neilsen PO, Prestwich GD, Kirschner MW, Cantley LC, Bourne HR. 2002. A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat. Cell Biol. 4:509-513. (pdf)


Xiao Z, Zhang N, Murphy DB, Devreotes PN. 1997. Dynamic distribution of chemoattractant receptors in living cells during chemotaxis and persistent stimulation. J. Cell Biol. 139:365-374. (pdf)


Zhang B, Ma Y, Guo H, Sun B, Niu R, et al. 2009. Akt2 is required for macrophage chemotaxis. Eur. J. Immunol. 39:894-901. (pdf)


Zhang S, Charest PG, Firtel RA. 2008. Spatiotemporal regulation of Ras activity provides directional sensing. Curr. Biol. 18:1587-1593. (pdf)