posted April 2013
Cytokinesis 101
Srivastava V, Robinson DN. Cytokinesis. In Lennarz & Lane (eds.) The Encyclopedia of Biological Chemistry, 2013;Waltham, MA: Academic Press. Vol. 3, pp. 622-626.
Aspiring for greatness
Kee YS, Robinson DN. Micropipette Aspiration for Studying Cellular Mechanosensory Responses and Mechanics. Methods Mol. Biol. 2013; 983:367-382.
http://www.ncbi.nlm.nih.gov/pubmed/23494318
Making cells walk
Lin B, Wang J, Ueno T, Harwell A, Inoue T, Levchenko A. synthetic spatially graded Rac Activation drives directed cell polarizationa and locomotion. PNAS 2012;E3668-77.
http://www.ncbi.nlm.nih.gov/pubmed/?term=Inoue+T+and+Lin+B
Moving proteins between organelles
Phua SC, Pohlmeyer C, Inoue T. Rapidly relocating molecules between organelles to manipulate small GTPase activity. ACS Chem Biol 2012;7:1950-1955.
http://www.ncbi.nlm.nih.gov/pubmed/?term=Inoue+T+and+Phua
posted January 2013
Dintzis, Renee and McBride, Jennifer, Chapter 1. Anatomy, Embryology, and Histology, in The Urinary Tract, A Comprehensive Guide to Patient Diagnosis and Management, Editors Hansel, D.E., McKenney, J.K., Stephenson, A.J. , and Chang, S.S. Springer, 2012.
posted November 2012
QDs Encapsulated in Lipids
Galloway, J.F., Winter, A., Lee, K.H., Park, J., Dvoracek, C., Devreotes, P.N., and Searson, P.C. 2012 Quantitative characterization of the lipid encapsulation of quantum dots for biomedical applications. Nanomedicine, 2012;8:1190-1199
Key words: Quantum dots, water solubilization, Micelles, Lipids
http://www.ncbi.nlm.nih.gov/pubmed/22197728
Fusing physics and cell biology
Robinson DN, Iglesias PA. Bringing the physical sciences into your cell biology research. Mol Biol Cell 2012;23:4167-4170.
Key words: cell biology research, collaboration, computational modeling, intedisciplinary research, physical science
http://www.ncbi.nlm.nih.gov/pubmed/23112230
New tricks for an old dog.
Shao W, Espenshade PJ. Expanding roles for SREBP in metabolism. Cell Metabolism 2012;16:414-419.
Key words: SREBP, hypoxia, cholesterol, lipid, diabetes, liver
http://www.ncbi.nlm.nih.gov/pubmed/23000402
posted September 2012
Modeling oxygen sensing
Porter JR, Lee CY, Espenshade PJ, Iglesias PA. Regulation of SREBP during hypoxia requires Ofd1-mediated control of both DNA binding and degradation. Mol Biol Cell 2012;23:3764-3774
http://www.ncbi.nlm.nih.gov/pubmed/22833559
Review of yeast lipid metabolism
Raychaudhuri S, Young BP, Espenshade PJ, Loewen CJ. Regulation of lipid metabolism: a tale of two yeasts. Curr Opin Cell Biol 2012;24:502-508.
http://www.ncbi.nlm.nih.gov/pubmed/22694927
Getting myosin in the right spot
Dickinson D, Robinson DN, Nelson WJ, Weis WI. alpha-catenin and IQGAP regulate myosin localization to control epithelial tube morphogenesis in Dictyostelium. Dev Cell 2012; 23:533-546.
http://www.ncbi.nlm.nih.gov/pubmed/22902739
A Hippo homolog regulates adhesion in Dictyostelium
Artemenko, Y., Batsios, P., Borleis, J., Gagnon, Z., Lee, J., Rohlfs, M., Sanséau, D., Willard, S.S., Schleicher, M., and Devreotes, P.N. Tumor suppressor Hippo/MST1 kinase mediates chemotaxis by regulating spreading and adhesion. PNAS 2012;109(34):13632-13637.
http://www.ncbi.nlm.nih.gov/pubmed/22847424
Novel oligomeric form of huntingtin N-terminal fragment is Aby recognized as a toxic fragment.
Nucifora LG, Burke KA, Feng X, Arbez N, Zhu S, Miller J, Yang G, Ratovitski T, Delannoy M, Muchowski PJ, Finkbeiner S, Legleiter J, Ross CA, Poirier MA. Identification of novel potentially toxic oligomers formed in vitro from mammalian-derived expanded huntingtin exon-1 protein. J Biol Chem;2012:287:16017-16028.
Key words: Negative stained electron microscopy, huntingins disease, fiber formation and aggregation.
http://www.ncbi.nlm.nih.gov/pubmed/22433867
Deletion of Sema3A is significantly lethal and revealed abnormal ultrastructure to smoke exposed mouse alveoli.
Becker PM, Tran TS, Delannoy MJ, He C, Shannon JM, McGrath-Morrow S. Semaphorin 3A contributes to distal pulmonary epithelial cell differentiation and lung morphogenesis. PLoS One. 2011;6(11):e27449.
Key words: TEM of lung tissue, glycogen accumulation, alveoli.
http://www.ncbi.nlm.nih.gov/pubmed/22096573
E-coli infections trigger Shiga-toxin 1 macropinocytosis in intestinal epithelium through actin remodeling.
Lukyanenko V, Malyukova I, Hubbard A, Delannoy M, Boedeker E, Zhu C, Cebotaru L, Kovbasnjuk O. Enterohemorrhagic Escherichia coli infection stimulates Shiga toxin 1 macropinocytosis and transcytosis across intestinal epithelial cells. Am J Physiol Cell Physiol. 2011;301:C1140-9.
Key words:TEM and SEM small intestine, E. coli infection, toxic bacterial infection.
http://www.ncbi.nlm.nih.gov/pubmed/21832249
posted August 2012
Changes in epithelial architecture during morphogenesis
Ewald AJ, Huebner RJ, Palsdottir H, Lee JK, Perez MJ, Jorgens DM, Tauscher AN, Cheung KJ, Werb Z, Auer M. Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium. J Cell Sci 2012;125:2638-2654.
http://www.ncbi.nlm.nih.gov/pubmed/22344263
Yeast vs. yeast: An evolutionary comparison of functional modules between fission and budding yeasts
Ryan CJ, Roguev A, Patrick K, Xu J, Jahari H, Tong Z, Beltrao P, Shales M, Qu H, Collins SR, Kliegman, JI, Jiang L, Kuo D, Tosti E, Kim H, Edelmann W, Keogh M, Greene D, Tang C, Cunningham P, Shokat KM, Cagney G, Svensson JP, Guthrie C, Espenshade PJ, Ideker T, Krogan NJ. Hierarchical modularity and the evolution of genetic interactomes across species. Mol. Cell. 2012;46:691-704.
http://www.ncbi.nlm.nih.gov/pubmed/22681890
Aquaporin-5 stabilizes microtubules to regulate paracellular permeability
Sidhaye VK, Chau E, Srivastava V, Sirimalle S, Balabhadrapatruni C, Aggarwal NR, D’Alessio FR, Robinson DN, King LS. A novel role for aquaporin-5 in enhancing microtubule organization and stability. PLoS ONE 2012;7(6):e38717
http://www.ncbi.nlm.nih.gov/pubmed/22715407
ken-and-barbie keeps stem cells in their niche
Issigonis M, Matunis E. The Drosophila BCL6 homolog ken and barbie promotes somatic stem cell self-renewal in the testis niche. Dev Bio 2012;368(2):181-192.
http://www.ncbi.nlm.nih.gov/pubmed/22580161
posted June 2012
The stresses of a break up
Mohan K, Iglesias PA, Robinson DN. Separation anxiety; stress, tension, and cytokinesis. Exp. Cell Res. 2012;318:1428-1434.
http://www.ncbi.nlm.nih.gov/pubmed/22487096
More than virus assembly
Ruch TR, Machamer CE. The coronavirus E protein: assembly and beyond. Viruses 2012;4:363-382.
http://www.ncbi.nlm.nih.gov/pubmed/22590676
Small protein, big job
Ruch TR, Machamer CE. A single polar residue and distinct membrane topologies impact the function of the infectious bronchitis coronavirus E protein. PLoS Pathogens 2012;8(5):e1002674.
http://www.ncbi.nlm.nih.gov/pubmed/22570613
posted May 2012
More Dsc-overies
Stewart EV, Lloyd SJ, Burg JS, Nwosu CC, Lintner RE, Daza R, Russ C, Ponchner K, Nusbaum C, Espenshade PJ. Yeast SREBP cleavage requires Cdc48 and Dsc5, a ubiquitin regulatory X domain-containing subunit of the Golgi Dsc E3 ligase. J Biol Chem 2011;287:672-81.
http://www.ncbi.nlm.nih.gov/pubmed/22086920
Rogers AB, Dintzis RZ. Liver and Gallbladder in Comparative Anatomy and Histology, A Mouse and Human Atlas. (Editors Piper M. Treuting and Suzanne M. Dintzis, Elseviers), UK and USA, 2012; Chapter 13, pgs. 193-199
A new way to control hypoxic gene expression
Lee CSY, Yeh TL, Hughes BT, Espenshade PJ. Regulation of the Sre1 hypoxic transcription factor by oxygen-dependent control of DNA binding. Mol Cell 2011;44:225-234.
http://www.ncbi.nlm.nih.gov/pubmed/22017871
Seeing is believing, structural insight into yeast SREBp regulation
Yeh TL, Lee CSY, Amzel LM, Espenshade PJ, and Bianchet MB. The hypoxic regulator of sterol synthesis Nro1 is a nuclear import adaptor. Structure 2011;19:503-14.
http://www.ncbi.nlm.nih.gov/pubmed/21481773
A new way to chop SREBP
Stewart EV, Nwosu CC, Tong Z, Roguev A, Cummins TD, Kim DU, Hayles J, Park HO, Hoe KL, Powell DW, Krogan NJ, Espenshade PJ. Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex. Mol Cell 2011;42:160-171.
http://www.ncbi.nlm.nih.gov/pubmed/21504829
Making something out of nothing
Porter JR, Burg JS, Espenshade PJ, Iglesias PA. Identifying a static nonlinear structure in a biological system using noisy, sparse data. J Theoretical Biol 2012;300:232-41.
http://www.ncbi.nlm.nih.gov/pubmed/22310068
Trachealess regulates ALL tracheal genesMaking something out of nothing
Porter JR, Burg JS, Espenshade PJ, Iglesias PA. Identifying a static nonlinear structure in a biological system using noisy, sparse data. J Theoretical Biol 2012;300:232-41.
http://www.ncbi.nlm.nih.gov/pubmed/22310068
Trachealess regulates ALL tracheal genes
Chung S, Chavez C, Andrew DJ. Trachealess (Trh) regulates all tracheal genes during Drosophila embryogenesis. Dev Biol 2011;360:160-172.
http://www.ncbi.nlm.nih.gov/pubmed/21963537
The Golgi stresses out
Chandran S, Machamer CE. Golgi organization and stress sensing. In “The Golgi apparatus: Structure, Functions and Mechanisms”. Ed., C.J. Hawkins, (Nova Science, Inc, Hauppauge NY), 2011;pp 1-42.
CERTain apoptotic stress
Chandran S, Machamer CE. Inactivation of ceramide transfer protein during proapoptotic stress by Golgi disassembly and caspase cleavage. Biochem J 2012;442:391-402.
http://www.ncbi.nlm.nih.gov/pubmed/22129459
Nakasone ES, Askautrud HA, Kees T, Park JH, Plaks V, Ewald AJ, Fein M, Rasch MG, Tan YX, Qiu J, Park J, Sinha P, Bissell MJ, Frengen E, Werb Z, Egeblad M. Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance. Cancer Cell 2012;21:488-503
http://www.ncbi.nlm.nih.gov/pubmed/22516258
Moving in the right direction
Cai H, Devreotes PN. Moving in the right direction: How eukaryotic cells migrate along chemical gradients. Semin Cell Dev Biol 2011;22:834-841.
http://www.ncbi.nlm.nih.gov/pubmed/21821139
Eggs over hard
Evans JP, Robinson DN. The spatial and mechanical challenges of female meiosis. Mol. Reprod. Dev. 2011;78:769-777.
http://www.ncbi.nlm.nih.gov/pubmed/21774026
Biased excitable networks
Iglesias PA, Devreotes PN. Biased excitable networks: how cells direct motion in response to gradients. Curr Opin Cell Biol 2012;757:451-468.
ACTINg Together Rather than in Isolation
Ueno T, Falkenburger BH, Pohlmeyer C, Inoue T. Triggering actin comets versus membrane ruffles: distinctive effects of phosphoinositides on actin reorganization. Sci Signal 2011;4(203):ra87.
http://www.ncbi.nlm.nih.gov/pubmed/22169478
Synthesizing computers in cells
Miyamoto T, Derose R, Suarez A, Ueno T, Chen M, Sun TP, Wolfgang MJ, Mukherjee C, Meyers DJ, Inoue T. Rapid and orthogonal logic gating with a gibberellin-induced dimerization system. Nat Chem Biol 2012;8:465-70.
http://www.ncbi.nlm.nih.gov/pubmed/22446836
Cytokinesis done right!
Kee YS, Ren Y, Dorfman D, Iijima M, Firtel RA, Iglesias PA, Robinson DN. A mechanosensory system governs myosin II accumulation in dividing cells. Mol Biol Cell 2012;23(8):1510-1523.
http://www.ncbi.nlm.nih.gov/pubmed/22379107
How does myosin feel about it?
Luo T, Mohan K, Srivastava V, Ren Y, Iglesias PA, Robinson DN. Understanding the cooperative interactions between myosin II and actin crosslinkers mediated by actin filaments during mechanosensation. Biophys. J 2012;102(2):238-247.
http://www.ncbi.nlm.nih.gov/pubmed/22339860
Forced to separate
Poirier CC, Ng WP, Robinson DN, Iglesias PA. Deconvolution of the cellular force-generating subsystems that govern cytokinesis furrow ingression. PLoS Comp. Biol. 2012;8(4):e1002467.
How cells divide
Robinson DN, Kee Y-S, Luo T, Surcel A. Understanding how dividing cells change shape. In Egelman EH (ed.) Comprehensive Biophysics, 2012; Elsevier, Amsterdam. Vol. 7, pp. 48-72.
14-3-3 in cytokihesis and cell mechanics
Robinson DN. 14-3-3, an integrator of cell mechanics and cytokinesis. Small GTPases 2010; 1(3): 165-169.
http://www.ncbi.nlm.nih.gov/pubmed/21686271
Huntingtin in Dictyostelium
Wang Y, Steimle PA, Ren Y, Ross CA, Robinson DN, Egelhoff TT, Sesaki H, and Iijima M. Dictyostelium huntingtin controls chemotaxis and cytokinesis through regulation of myosin II phosphorylation. Mol Biol Cell 2011;22:2270-2281.
http://www.ncbi.nlm.nih.gov/pubmed/21562226
posted September 2011
Artemenko Y, Swaney K, Devreotes PN. Assessment of development and chemotaxis in Dictyostelium discoideum mutants. Meth Mol Biol 2011;769:287-309.
http://www.ncbi.nlm.nih.gov/pubmed/21748684
Regulating the target of cholesterol-lowering statin drugs
Burg JS, Espenshade PJ. Regulation of HMG-CoA reductase in mammals and yeast. Prog Lipid Res 2011;50:403-410.
http://www.ncbi.nlm.nih.gov/pubmed/21801748
Sugar controls synthesis of sterols in yeast
Burg JS, Espenshade PJ. Glucose controls phosphoregulation of HMG-CoA reductase through the PP2A-related phosphatase Ppe1 and Insig in fission yeast. J Biol Chem 2011;286:27139-27146.
http://www.ncbi.nlm.nih.gov/pubmed/21680738
Cai H, Huang CH, Devreotes PN, Iijima M. Analysis of chemotaxis in dictyostelium. Methods Mol Biol 2011;757:451-468.
http://www.ncbi.nlm.nih.gov/pubmed/21909927
Novel signal for Golgi targeting
Cohen JR, Lin LD, Machamer CE. Identification of a Golgi targeting signal in the cytoplasmic tail of the severe actute respiratory syndrome coronavirus envelope protein. J Virol 2011;85:5794-4803.
http://www.ncbi.nlm.nih.gov/pubmed/21450821
de Keijzer S, Galloway J, Devreotes PN, and Iglesias PA. 2011 Disrupting microtubule network immobilizes amoeboid chemotactic receptor in the plasma membrane. Biochimica et Biophysica Acta, 1808:1701-1708.
http://www.ncbi.nlm.nih.gov/pubmed/21334306
Learning about stem cells from fruit fly testes
De Cuevas M, Matunis EL. The stem cell niche: lessons ftom the Drosophila testis. Development 2011;138:2861-2869.
http://www.ncbi.nlm.nih.gov/pubmed/21693509
How we can sweat, spit and secrete ALOT
Fox RM, Hanlon CD, Andrew DJ. The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity. J Cell Biol 2010;191:479-492.
http://www.ncbi.nlm.nih.gov/pubmed/21041443
Gao RC, Zhang XD, Sun YH, Kamimura Y, Mogilner A, Devreotes PN, Zhao M. 2011. Different roles of Membrane potentials in electrotaxis and chemotaxis of Dictyostelium Cells. Eukaryot Cell, 2011;10:1251-1256.
http://www.ncbi.nlm.nih.gov/pubmed/21743003
Sticking to our job and becoming big enough to do it
Maruyama R, Grevengoed E, Stempniewicz P, Andrew DJ. Genome-wide analysis reveals a major role in cell fate maintenance and an unexpected role in endoreduplication for the Drosophila FoxA gene fork head. PLoS One 2011;6:e20901.
http://www.ncbi.nlm.nih.gov/pubmed/21698206
Mathematics meets biology in the sterol pathway
Porter JR, Burg JS, Espenshade PJ, Iglesias PA. Ergosterol regulates SREBP cleavage in fission yeast. J Biol Chem 2010;285;41051-41061.
http://www.ncbi.nlm.nih.gov/pubmed/20959444
Coronaviruses need help escaping the cell
Ruch TR, Machamer CE. The hydrophobic domain of the infectious bronchitis virus E protein alters the host secretory pathway and is important for release of infectious virus. J Virol 2011;85:675-685.
http://www.ncbi.nlm.nih.gov/pubmed/21047962
Escaping the PIP3
Tang M, Iijima M, and Devreotes PN. 2011. Generation of cells that ignore the effects of PIP3 on cytoskeleton. Cell Cycle, 2011;10(17).
http://www.ncbi.nlm.nih.gov/pubmed/21869609
Palmitoylation and beta-adrenergic receptor trafficking
Zuckerman DM, Hicks SW, Charron G, Hang HC, Machamer CE. Differential regulation of two palmitoylation sites in the cytoplasmic tail of the beta-1 adrenergic receptor. J Biol Chem 201;286:19014-19023.
http://www.ncbi.nlm.nih.gov/pubmed/21464135
posted March 2011
Shedding light on subcellular signaling
Umeda N, Ueno T, Pohlmeyer C, Nagano T, Inoue T. A photocleavable rapamycin conjugate for spatiotemporal control of small GTPase activity. J Am Chem Soc 2011;133:12-14.
http://www.ncbi.nlm.nih.gov/pubmed?term=Umeda%20N%20and%20Ueno%20T
Mediators of PTEN in Directed Cell Migration
Tang M, Iijima M, Kamimura Y, Chen L, Long Y, Devreotes PN. Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN. Mol. Biol. Cell. 2011;22:437-447.
http://www.ncbi.nlm.nih.gov/pubmed/21169559
posted December 2010
Hard and Soft Eggs
Larson SM, Lee HJ, Hung P-H, Matthews LM, Robinson DN, and Evans JP. Cortical mechanics and meiosis II completion in mammalian oocytes are mediated by myosin-II and ezrin-radixin-moesin (ERM) proteins. Mol Biol Cell 2010;21:3182-3192.
http://www.ncbi.nlm.nih.gov/pubmed/20660156
Integrating Key Cytoskeletal Elements in Cell Division and Cell Mechanics
Zhou Q, Kee Y-S, Poirier CC, Jilenik C, Osborne J, Divi S, Surcel A, Tran ME, Eggert US, Müller-Taubenberger A, Iglesias PA, Cotter RJ, and Robinson DN. 14-3-3 coordinates microtubules, Rac, and myosin II to control cell mechanics and cytokinesis. Curr. Biol 2010; 20: 1881-1889.
http://www.ncbi.nlm.nih.gov/pubmed/20951045
Biochemical-mechanical feedback in cell shape change
Surcel A, Kee Y-S, Luo T, Robinson DN. Cytokinesis through biochemical-mechanical feedback loops. Semin Cell De Bio. 2010; 21:866-873.
http://www.ncbi.nlm.nih.gov/pubmed/20709619
How you feel stress
Luo T, Robinson DN. The role of the actin cytoskeleton in mechanosensation. Kamkin A. & Kiseleva I. eds. Mechanosensitivity in Cells and Tissues 4: Mechanosensitivity and Mechanotransduction, 2011; Springer-Verlag, New York. pp. 25-65.
posted September 2010
Chemotaxis: TORCing to Ras
Cai H, Das S, Kamimura Y, Comer FI, Parent DA, Devreotes PN. Ras-mediated activation and inactivation of the TorC2-PKB pathway are critical for chemotaxis. J Cell Biol 2010;190:233-245.
http://www.ncbi.nlm.nih.gov/pubmed/20660630
Cytoskeleton hrlps control the leading edge
Lee S, Shen Z, Robinson DN, Briggs S, Firtel RA. Involement of the cytoskeleton in controlling leading edge function during chemotaxis. Mol Biol Cell 2010;21:1810-1824.
http://www.ncbi.nlm.nih.gov/pubmed/20375144
Novel strategies for gene delivery to epithelial cells
Bhise N, Gray RS, Sunshine J, Htet S, Ewald AJ, Green JJ. The relationship between terminal functionalization and molecular weight of a gene delivery polymer and transfection efficacy in mammary epithelial 2-D cultures and 3-D organotypic cultures. Biomaterials 2010;31:8088-8096.
http://www.ncbi.nlm.nih.gov/pubmed/20674001
Grease needed for coronaviorus-mediated cell fusion
McBride CE, Machamer CE. Palmitoylation of SARS-CoV S protein is necessary for partitioning into detergent-resistant membranes and cell-cell fusion but not interaction with M protein. Virology 2010;405:139-148.
http://www.ncbi.nlm.nih.gov/pubmed/20580052
Ups: we deliver
Tamura Y, Iijima M, Sesaki H. Mdm35p imports Ups proteins into the mitochondrial intermembrane space by functional complex formation. EMBO J 2010;29:2875-2887.
http://www.ncbi.nlm.nih.gov/pubmed/20622808
Fishing PIP3 binding proteins
Zhang P, Wang Y, Sesaki H, Iijima M. Proteomic identification of phosphatidylinositol (3,4,5) triphosphate-binding proteins in Dictyostelium discoideum. Proc Natl Acad Sci USA 2010;107:11829-34.
http://www.ncbi.nlm.nih.gov/pubmed/20547830
posted August 2010
How to make tubes in animals
Kerman BE, Andrew DJ. Staying alive: Dalmation mediated blocking of apoptosis is essential for tissue maintenance. Dev Dynamics 2010;239:1609-1621.
Key words: apoptosis; dalmation; hete4rochromatin; HP1; peripheral nervous system;p salivary duct; trachea
http://www.ncbi.nlm.nih.gov/pubmed/20503358
posted April 2010
Automated analysis of amoeboid motility
Xiong Y, Kabacoff C, Franca-Koh J, Devreotes PN, Robinson DN, Iglesias PA. Automated characterization of cell shape changes during amoeboid motility by skeletonization. BMC Syst. Biol., 2010;4:33.
http://www.ncbi.nlm.nih.gov/pubmed/20334652
Radhakrishnan A, Sun LP, Espenshade PJ, Goldstein JL, Brown MS. “Chapter 298. The SREBP Pathway: Gene Regulation through Sterol Sensing and Gated protein Trafficking.” In Handbook of Cell Signaling, 2nd edition (R. Bradshaw and E. Dennis, eds.). Academic Press, San Diego.
Nanotopographic regulation of cardiomyocytes in vitro
Kim DH, Lipke EA, Kim P, Cheong R, Thompson S, Delannoy M, Suh KY, Tung L, Levchenko A. Nanoscale cues regulate the structure and function of macroscopi8c cardiac tissue constructs. Proc Natl Acad Sci USA 2010;107:565-570.
http://www.ncbi.nlm.nih.gov/pubmed/20018748
What happens when fungi hold their breath?
Bien CM, Espenshade PJ. Sterol regulatory element binding proteins in fungi: hypoxic transcription factors linked to pathogenesis. Eukaryot Cell 2010;9:352-359.
http://www.ncbi.nlm.nih.gov/pubmed/20118213
How to make tubes in animals
Andrew DJ, Ewald AJ. Morphogenesis of epithelial tubes: Insights into tube formation, elongation, and elaboration. Dev Biol 2010:340:34-55.
http://www.ncbi.nlm.nih.gov/pubmed/19778532
posted March 2010
Mapping SARS-CoV protein interactions
McBride CE, Machamer CE. A single tyrosine residue in the SARS coronavirus membrane protein cytoplasmic tail is necessary for efficient interaction with spike protein. J Virol 2010;84:1891-1901.
Key words: SARS; enveloped virus; spike; membrane; Golgi
http://www.ncbi.nlm.nih.gov/pubmed/20007283
Franca-Koh J, Willard SS, Devreotes PN 2009 G-Protein Signaling in Chemotaxis. In: Ralph A. Bradshaw and Edward A. Dennis, editors, Handbook of Cell Signaling 2nd edition. Oxford: Academic Press, pp. 1705-1712.
A review of chemotaxis in eukaryotic cells
Swaney KF, Huang CH, Devreotes PN. Eukaryotic Chemotaxis: A network of signaling pathways controls motility, directional sensing, and polarity. Annu Rev Biophys 2010;278;20445-20448.
http://www.jbc.org/content/278/23/20445.long
The signaling pathway in Dictyostelium chemotaxis
Kamimura Y, Devreotes PN 2010 Phosphoinositide-dependent protein kinase (PDK) activity regulates phosphatidylinositol 3,4,5-trisphosphate-dependent and -independent protein kinase B activation and chemotaxis. J Biol Chem 2010;285(11):7938-7946.
http://www.ncbi.nlm.nih.gov/pubmed/20075071
Location, Location, Location
Komatsu T, Kukelyansky I, McCaffery JM, Ueno T, Varela LC, Inoue T. Organelle-specific, rapid induction of molecular activities and membrane tethering. Nature Methods 2010;Mar;7(3):206-208.
http://www.ncbi.nlm.nih.gov/pubmed/20154678
posted January 2010
Tracheal tube length control in Drosophila
Chung S, Vining MS, Bradley PL, Chan CC, Wharton KA Jr, Andrew DJ. Serano (sano) functions with the planar cell polarity genes to control tracheal tube length. PLoS Genet 2009;5(11):e1000746.
http://www.ncbi.nlm.nih.gov/pubmed/19956736
The ABC's of multidrug resistance transporters in yeast
Paumi C, Chuk M, Snider J, Staglijar I, Michaelis S. ABC Transporters in Saccharomyces cerevisiae and their Interactors: New Technology Advances the Biology of the ABCC (mrp) Subfamily. Micro & Mol Biol Rev 2009;7:57-593.
http://www.ncbi.nlm.nih.gov/pubmed/19946134
How to spy on tumors, a how-to guide
Ewald AJ, Werb Z, Egeblad M. Dynamic, long-term, in vivo imaging of tumor-stroma interactions in mouse models of breast cancer using spinning disk confocal microscopy. Cold Spring Harbor Perspective Biology, Chapter 23. In: Live Cell Imaging, A Laboratory Manual. Second Edition, Edited by Robert D. Goldman, Jason R. Swedlow, and David L. Spector. Cold Spring Harbor Laboratory Press, pp. 419-439.
posted December 2009
The genetics of clogged arteries
Kwiterovich PO, Espenshade PJ. "Chapter 8: Disorders of LDL Metabolism." In The Johns Hopkins University Textbook of Dyslipidemia (P.O. Kwiterovich, ed.) Wolters Kluwer/Lippincott Williams & Wilkens, Philadelphia. PA. 2009;pp. 88-104.
Signaling to nuclear membrane proteins
Tifft KE, Bradbury KA, Wilson KL. Tyrosine phosphorylation of nuclear-membrane protein emerin by Src, Abl and other kinases. J Cell Science 2009;122:3780-90.
http://www.ncbi.nlm.nih.gov/pubmed/19789182
New friends for BAF, the mobile nuclear lamina component
Montes de Oca R, Shoemaker CJ, Gucek M, Cole RN, Wilson KL. Barrier-to-autointegration factor proteome reveals chromatin-regulatory partners. PLoS ONE 2009;4(9):e7050.
http://www.ncbi.nlm.nih.gov/pubmed/19759913
posted November 2009
Intramembrane proteolysis activates SREBP in a fungal pathogen
Bien CM, Chang YC, Nes WD, Kwon-Chung KJ, and Espenshade PJ. C. neoformans Site-2 protease is required for virulence and survival in the presence of azole drugs. Mol. Microbiol. 2009;74:672-690.
http://www.ncbi.nlm.nih.gov/pubmed/19818023
Sensing Oxygen in a Fungal Pathogen
Chang YC, Ingavale SS, Bien C, Espenshade PJ, and Kwon-Chung KJ. Conservation of the SREBP pathway and its pathobiological importance in Cryptococcus neoformans. Eukaryot Cell. 2009;8:1770-1779.
http://www.ncbi.nlm.nih.gov/pubmed/19749173
posted October 2009
Jak-STAT regulation of male germline stem cell establishment during Drosophila embryogenesis
Sheng XR, Posenau T, Gumulak-Smith JJ, Matunis EL, Van Doren M, Wawersik M. Jak-STAT regulation of male germline stem cell establishment during Drosophila embryogenesis. Dev Biol 2009;334:335-344.
http://www.ncbi.nlm.nih.gov/pubmed/19643104
Stem cell competition in the Drosophila testis stem cell niche
Issigonis M, Tulina N,de Cuevas M, Brawley C, Sandler L, Matunis E. JAK-STAT signal inhibition regulates competition in the Drosophila testis stem cell niche. Science 2009;326:153-156.
http://www.ncbi.nlm.nih.gov/pubmed/19797664
posted September 2009
Mitochondrial division in mice
Wakabayashi J, Zhang Z, Wakabayashi N, Tamura Y, Fukaya M, Kensler TW, Iijima M, Sesaki H. The dyanmin-related GTPase Drp1 is required for embryonic and brain development in mice. J Cell Biol 2009;186:805-816.
http://www.ncbi.nlm.nih.gov/pubmed/19752021
Dividing Cells 'Feel' Their Way Out of Warp.
Ren Y, Effler JC, Norstrom M, Luo T, Firtel RA, Iglesias PA, Rock RS, Robinson DN. Mechanosensing through cooperative interactions between myosin-II and the actin crosslinker cortexillin-I. Curr Biol 2009;19:1421-1428.
http://www.ncbi.nlm.nih.gov/pubmed/19646871
posted August 2009
Outta my way! Returning stem cell daughters win niche space
Sheng XR, Brawley C, Matunis EL. Dedifferentiating spermatogonia outcompete somatic stem cells for niche occupancy in the drosophila testis. Cell Stem Cell 2009;5(2):191-203.
http://www.ncbi.nlm.nih.gov/pubmed/19664993
ZMPSTE24 and premature aging disorders
Barrowman J, Michaelis S. ZMPSTE24, an integral membrane zinc metalloprotease with a connection to progeroid disorders. Biol Chem 2009;390(8):761-773.
http://www.ncbi.nlm.nih.gov/pubmed/19453269
posted July 2009
PTEN in mechanosensing
Pramanik Md K, Iijima M, Iwadate Y, Yumura S. PTEN is a mechanosensing signal transducer for myosin II localization in Dictyostelium cells. Genes to Cells 2009;14:821-834.
http://www.ncbi.nlm.nih.gov/pubmed/19515202
Making a complete import machinery
Tamura Y, Harada Y, Shiota T, Yamano K, Watanabe K, Yokota M, Yamamoto H, Sesaki H, Endo T. Tim23Tim50 pair coordinates functions of translocators and motor proteins in mitochondrial protein import. J Cell Biol 2009;184:129-41.
http://www.ncbi.nlm.nih.gov/pubmed/19139266
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