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The Epigenetics Program

Researchers in neurogenetics are just beginning to see the importance of little-studied processes such as methylation—the addition of methyl groups to DNA, as a way of silencing specific genes.  The goal of neurogenetics is to understand which genes are silenced and what the consequences are of silencing them.  Trained as a psychiatrist and neuroscientist, Andy Feinberg, M.D. is an international leader in epigenetics and until now, he has not had the opportunity to study epigenetics in the brain.  Dr. Feinberg has developed state-of-the-art microarray chips to detect methylation of genes and we anticipate that many groups will want to utilize his expertise and Center.  The BSI has supported the expansion of this novel epigenetic resource to make it available to Johns Hopkins University neuroscientists.  To help set priorities for the use of the Epigenetics Center, the Scientific Review Panel will review and provide small grant support for studies to be conducted.  Additionally, The School of Medicine is devoting new space to this Center.

Investigator
Andrew Feinberg, M.D.
Funded Projects
Translational Program
The Behavioral Testing Program
The High Throughput Screening Program
The Mouse "Forward Genetics" Program
The Epigenetics Program
mouse limb
mouse limb
Whole mount staining reveals the pattern of  sensory neuron (red) and motor neuron (green) innervation of the developing mouse forelimb. Image by Rasi Wickramasinghe and David Ginty

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Johns Hopkins Brain Science Institute
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