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Selected Publications

Selected discoveries published by students in the Graduate Program in Biological Chemistry, students names in bold:

2013 | 2012 | 20112010 | 2009 | | 20082007 | 2006 |  2005 | 2004 | 2003 | 2002 | 2001 |  2000 | 1999 | 1998 | 1997



Groves J., Lee A., Yildirir G., and Zachara N.E. (2013) Dynamic O-GlcNAcylation and its roles in the cellular stress response and homeostasis. Cell Stress and Chaperones, Sep;18(5):535-58.

Petro EJ1, Raben DM. (2013) Bacterial expression strategies for several Sus scrofa diacylglycerol kinase alpha constructs: solubility challenges. Sci Rep. 2013;3:1609. doi: 10.1038/srep01609.

Cai Z, Luo W, Zhan H, Semenza GL. Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart. Proc. Natl. Acad. Sci. USA 110(43):17462-17467 (2013). PMID: 24101519.


Gan X, Gould SJ (2012) "HIV Pol inhibits HIV budding and mediates the severe budding defect of Gag-Pol." PLoS One. 7(1):e29421.


Gan, X., and Gould, S.J. Identification of an inhibitory budding signal that blocks the release of HIV particles and exosome/microvesicle proteins. Mol Biol Cell 22, 817-830.

He, L., Wang, X., Montell, D.J. Shining light on Drosophila oogenesis: live imaging of egg development. Curr Opin Genet Dev. 2011 Oct;21(5):612-9. Epub 2011 Sep 17.

Kim, J.H., Cho, A., Yin, H., Schafer ,D.A., Mouneimne, G., Simpson, K.J., Nguyen, K.V., Brugge, J.S., Montell, D.J. Psidin, a conserved protein that regulates protrusion dynamics and cell migration. Genes Dev. 2011 Apr 1;25(7):730-41. Epub 2011 Mar 15.

Kim, M.S., Zhong, J., Kandasamy, K., Delanghe, B., and Pandey, A. Systematic evaluation of alternating CID and ETD fragmentation for phosphorylated peptides. Proteomics 11, 2568-2572.

Shen, W., Adegbola, A.A., Luo, J., Chess, A. and Montell, C. (2011) Function of rhodopsin in temperature discrimination in Drosophila. Science, 1333-1336.

Song, W.J., Seshadri, M., Ashraf, U., Mdluli, T., Mondal, P., Keil, M., Azevedo, M., Kirschner, L.S., Stratakis, C.A., and Hussain, M.A. Snapin mediates incretin action and augments glucose-dependent insulin secretion. Cell Metab 13, 308-319.

Yoon, W.H., Meinhardt, H., Montell. D.J. miRNA-mediated feedback inhibition of JAK/STAT morphogen signalling establishes a cell fate threshold. Nat Cell Biol. 2011 Aug 21;13(9):1062-9. doi: 10.1038/ncb2316. PubMed PMID: 21857668; PubMed

Zeidan, Q., and Hart, G.W. The intersections between O-GlcNAcylation and phosphorylation: implications for multiple signaling pathways. J Cell Sci 123, 13-22.


He L., Wang X, Tang HL, Montell DJ. (2010) Tissue elongation requires oscillating contractions of a basal actomyosin network. Nat Cell Biol, 12, 1133-42

Hesketh, G.G., Shah, M.H., Halperin, V.L., Cooke, C.A., Akar, F.G., Yen, T.E., Kass, D.A., Machamer, C.E., Van Eyk, J.E., and Tomaselli, G.F. (2010). Ultrastructure and regulation of lateralized connexin43 in the failing heart. Circ Res 106, 1153-1163.

Kane, L.A., Youngman, M.J., Jensen, R.E., and Van Eyk, J.E. (2010). Phosphorylation of the F(1)F(o) ATP synthase beta subunit: functional and structural consequences assessed in a model system. Circ Res 106, 504-513.

Kim, M.S., Kandasamy, K., Chaerkady, R., and Pandey, A. (2010). Assessment of Resolution Parameters for CID-Based Shotgun Proteomic Experiments on the LTQ-Orbitrap Mass Spectrometer. J Am Soc Mass Spectrom. 21, 1606-1611.

Kwon, Y., Kim, S.H., Ronderos, D., Lee, Y., Akitake, B. Woodward, O., Guggino, W.B., Smith, D. and Montell, C. 2010. Drosophila TRPA1 channel is required to avoid the naturally occurring insect repellent citronellal. Curr. Biol. 20, 1672-1678.

Kwon, Y., Shim, H.S., Shen, W. and Montell C. 2010. Fine thermotactic discrimination between the optimal and slightly cool temperatures via a TRPV channel in chordotonal neurons. J. Neurosci. 30, 10465-10471.

Wang, X., Wang, T., Jiao, Y., von Lintig, J., and Montell, C. (2010). Requirement for an enzymatic visual cycle in Drosophila. Curr Biol 20, 93-102.

Wang X.* , He L.* , Wu Y.I., Hahn K.M. & Montell D.J. Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo. Nature Cell Biology, 12, 591–597 (2010). * Co- first authors.

Wang, Z., Udeshi, N.D., Slawson, C., Compton, P.D., Sakabe, K., Cheung, W.D., Shabanowitz, J., Hunt, D.F., and Hart, G.W. (2010). Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis. Sci Signal 3, ra2.

Zeidan, Q., and Hart, G.W. (2010). The intersections between O-GlcNAcylation and phosphorylation: implications for multiple signaling pathways. J Cell Sci 123, 13-22.

Zeidan, Q., Wang, Z., De Maio, A., and Hart, G.W. (2010). O-GlcNAc cycling enzymes associate with the translational machinery and modify core ribosomal proteins. Mol Biol Cell 21, 1922-1936.



Jang, A. C.-C., Chang, Y.-C., Bai, J. and Montell, D.J.(2009) Border-cell migration requires integration of spatial and temporal signals by the BTB protein Abrupt. Nature Cell Biology. May; 11(5):569-79.

Lee, C.H., and Coulombe, P.A. (2009). Self-organization of keratin intermediate filaments into cross-linked networks. J Cell Biol 186, 409-421.

Moon, S.J., Lee, Y., Jiao, Y., and Montell, C. (2009). A Drosophila gustatory receptor essential for aversive taste and inhibiting male-to-male courtship. Curr Biol 19, 1623-1627.




Jiao, Y., Moon, S.J., Wang, X., Ren, Q., and Montell, C. (2008). Gr64f is required in combination with other gustatory receptors for sugar detection in Drosophila. Curr Biol 18, 1797-1801. 

Kwon, Y., Shim, H.S., Wang, X., and Montell, C. (2008). Control of thermotactic behavior via coupling of a TRP channel to a phospholipase C signaling cascade. Nat Neurosci 11, 871-873.

Wang, T., Wang, X., Xie, Q., and Montell, C. (2008). The SOCS box protein STOPS is required for phototransduction through its effects on phospholipase C. Neuron 57, 56-68.

Wang, Z., Gucek, M., and Hart, G.W. (2008). Cross-talk between GlcNAcylation and phosphorylation: site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc. Proc Natl Acad Sci U S A 105, 13793-13798.

Zhao, Z., Lindsay, M.E., Roy Chowdhury, A., Robinson, D.R., and Englund, P.T. (2008). p166, a link between the trypanosome mitochondrial DNA and flagellum, mediates genome segregation. EMBO J 27, 143-154.



Jiao, Y., Moon, S.J., and Montell, C. (2007). A Drosophila gustatory receptor required for the responses to sucrose, glucose, and maltose identified by mRNA tagging. Proc Natl Acad Sci U S A 104, 14110-14115. 

Kim, S., and Coulombe, P.A. (2007). Intermediate filament scaffolds fulfill mechanical, organizational, and signaling functions in the cytoplasm. Genes Dev 21, 1581-1597.

Kim, S., Kellner, J., Lee, C.H., and Coulombe, P.A. (2007). Interaction between the keratin cytoskeleton and eEF1Bgamma affects protein synthesis in epithelial cells. Nat Struct Mol Biol 14, 982-983.

Kwon, Y., Hofmann, T., and Montell, C. (2007). Integration of phosphoinositide- and calmodulin-mediated regulation of TRPC6. Mol Cell 25, 491-503.

Liu, Y., Promeneur, D., Rojek, A., Kumar, N., Frokiaer, J., Nielsen, S., King, L.S., Agre, P., and Carbrey, J.M. (2007). Aquaporin 9 is the major pathway for glycerol uptake by mouse erythrocytes, with implications for malarial virulence. Proc Natl Acad Sci U S A 104, 12560-12564.

Wang, T., Jiao, Y., and Montell, C. (2007). Dissection of the pathway required for generation of vitamin A and for Drosophila phototransduction. J Cell Biol 177, 305-316. 


Chen, C., Saxena, A.K., Simcoke, W.N., Garboczi, D.N., Pedersen, P.L., and Ko, Y.H. (2006). Mitochondrial ATP synthase. Crystal structure of the catalytic F1 unit in a vanadate-induced transition-like state and implications for mechanism. J Biol Chem 281, 13777-13783.

Kane, L.A., Yung, C.K., Agnetti, G., Neverova, I., and Van Eyk, J.E. (2006). Optimization of paper bridge loading for 2-DE analysis in the basic pH region: application to the mitochondrial subproteome. Proteomics 6, 5683-5687.

Kim, S., Wong, P., and Coulombe, P.A. (2006). A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth. Nature 441, 362-365.

Kwon, Y., and Montell, C. (2006). Dependence on the Lazaro phosphatidic acid phosphatase for the maximum light response. Curr Biol 16, 723-729.

Moon, S.J., Kottgen, M., Jiao, Y., Xu, H., and Montell, C. (2006). A taste receptor required for the caffeine response in vivo. Curr Biol 16, 1812-1817.  

Tong, X., and Coulombe, P.A. (2006). Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion. Genes Dev 20, 1353-1364.



Fang, Q., and Shortle, D. (2005). A consistent set of statistical potentials for quantifying local side-chain and backbone interactions. Proteins 60, 90-96.

Fang, Q., and Shortle, D. (2005). Enhanced sampling near the native conformation using statistical potentials for local side-chain and backbone interactions. Proteins 60, 97-102.

Hu, Z., Cha, S.H., van Haasteren, G., Wang, J., and Lane, M.D. (2005). Effect of centrally administered C75, a fatty acid synthase inhibitor, on ghrelin secretion and its downstream effects. Proc Natl Acad Sci U S A 102, 3972-3977.

Hu, Z., Dai, Y., Prentki, M., Chohnan, S., and Lane, M.D. (2005). A role for hypothalamic malonyl-CoA in the control of food intake. J Biol Chem 280, 39681-39683.

Lee, H., Iida, T., Mizuno, A., Suzuki, M., and Caterina, M.J. (2005). Altered thermal selection behavior in mice lacking transient receptor potential vanilloid 4. J Neurosci 25, 1304-1310.

Liu, K., Kozono, D., Kato, Y., Agre, P., Hazama, A., and Yasui, M. (2005). Conversion of aquaporin 6 from an anion channel to a water-selective channel by a single amino acid substitution. Proc Natl Acad Sci U S A 102, 2192-2197.

Liu, Y., Motyka, S.A., and Englund, P.T. (2005). Effects of RNA interference of Trypanosoma brucei structure-specific endonuclease-I on kinetoplast DNA replication. J Biol Chem 280, 35513-35520.

Silver, D.L., Geisbrecht, E.R., and Montell, D.J. (2005). Requirement for JAK/STAT signaling throughout border cell migration in Drosophila. Development 132, 3483-3492.

Wang, T., Jiao, Y., and Montell, C. (2005). Dissecting independent channel and scaffolding roles of the Drosophila transient receptor potential channel. J Cell Biol 171, 685-694.

Wang, T., and Montell, C. (2005). Rhodopsin formation in Drosophila is dependent on the PINTA retinoid-binding protein. J Neurosci 25, 5187-5194.

Wang, T., Xu, H., Oberwinkler, J., Gu, Y., Hardie, R.C., and Montell, C. (2005). Light activation, adaptation, and cell survival functions of the Na+/Ca2+ exchanger CalX. Neuron 45, 367-378.  



Chen, C., Ko, Y., Delannoy, M., Ludtke, S.J., Chiu, W., and Pedersen, P.L. (2004). Mitochondrial ATP synthasome: three-dimensional structure by electron microscopy of the ATP synthase in complex formation with carriers for Pi and ADP/ATP. J Biol Chem 279, 31761-31768.

Fang, Y., Morrell, J.C., Jones, J.M., and Gould, S.J. (2004). PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins. J Cell Biol 164, 863-875.

Lee, S.J., and Montell, C. (2004). Light-dependent translocation of visual arrestin regulated by the NINAC myosin III. Neuron 43, 95-103.

Lee, S.J., and Montell, C. (2004). Suppression of constant-light-induced blindness but not retinal degeneration by inhibition of the rhodopsin degradation pathway. Curr Biol 14, 2076-2085.

Lee, S.J., Xu, H., and Montell, C. (2004). Rhodopsin kinase activity modulates the amplitude of the visual response in Drosophila. Proc Natl Acad Sci U S A 101, 11874-11879.  

Silver, D.L., Naora, H., Liu, J., Cheng, W., and Montell, D.J. (2004). Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility. Cancer Res 64, 3550-3558.

Xu, H., Lee, S.J., Suzuki, E., Dugan, K.D., Stoddard, A., Li, H.S., Chodosh, L.A., and Montell, C. (2004). A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen. EMBO J 23, 811-822. 



Fang, Q., and Shortle, D. (2003). Prediction of protein structure by emphasizing local side-chain/backbone interactions in ensembles of turn fragments. Proteins 53 Suppl 6, 486-490.

Gao, S., and Lane, M.D. (2003). Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem. Proc Natl Acad Sci U S A 100, 5628-5633.

Hu, Z., Cha, S.H., Chohnan, S., and Lane, M.D. (2003). Hypothalamic malonyl-CoA as a mediator of feeding behavior. Proc Natl Acad Sci U S A 100, 12624-12629.

Lee, M.G., and Pedersen, P.L. (2003). Glucose metabolism in cancer: importance of transcription factor-DNA interactions within a short segment of the proximal region og the type II hexokinase promoter. J Biol Chem 278, 41047-41058.

Lee, S.J., Xu, H., Kang, L., Amzel, M. and Montell, C. 2003. Light adaptation through phosphoinositide-regulated translocation of Drosophila visual arrestin. Neuron 39, 121-132. 

Li, X., and Gould, S.J. (2003). The dynamin-like GTPase DLP1 is essential for peroxisome division and is recruited to peroxisomes in part by PEX11. J Biol Chem 278, 17012-17020.

Silver, D.L., and Montell, D.J. (2003). A new trick for Cyclin-Cdk: activation of STAT. Dev Cell 4, 148-149.



Bai, J., and Montell, D. (2002). Eyes absent, a key repressor of polar cell fate during Drosophila oogenesis. Development 129, 5377-5388.

Li, X., Baumgart, E., Morrell, J.C., Jimenez-Sanchez, G., Valle, D., and Gould, S.J. (2002). PEX11 beta deficiency is lethal and impairs neuronal migration but does not abrogate peroxisome function. Mol Cell Biol 22, 4358-4365.

Li, X., and Gould, S.J. (2002). PEX11 promotes peroxisome division independently of peroxisome metabolism. J Cell Biol 156, 643-651.



Lee, S.J., and Montell, C. (2001). Regulation of the rhodopsin protein phosphatase, RDGC, through interaction with calmodulin. Neuron 32, 1097-1106. 

Liu, Y., and Montell, D.J. (2001). Jing: a downstream target of slbo required for developmental control of border cell migration. Development 128, 321-330.

Ma, L., Yamada, S., Wirtz, D., and Coulombe, P.A. (2001). A 'hot-spot' mutation alters the mechanical properties of keratin filament networks. Nat Cell Biol 3, 503-506.

Silver, D.L., and Montell, D.J. (2001). Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila. Cell 107, 831-841.

Wang, Z., and Englund, P.T. (2001). RNA interference of a trypanosome topoisomerase II causes progressive loss of mitochondrial DNA. EMBO J 20, 4674-4683.

Xu, X.Z., Moebius, F., Gill, D.L., and Montell, C. (2001). Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform. Proc Natl Acad Sci U S A 98, 10692-10697. 



Bai, J., Uehara, Y., andMontell, D.J. (2000). Regulation of invasive cell behavior by taiman, a Drosophila protein related to AIB1, a steroid receptor coactivator amplified in breast cancer. Cell 103, 1047-1058.

Wang, Z., Morris, J.C., Drew, M.E., and Englund, P.T. (2000). Inhibition of Trypanosoma brucei gene expression by RNA interference using an integratable vector with opposing T7 promoters. J Biol Chem 275, 40174-40179.

Xu, X.Z., Chien, F., Butler, A., Salkoff, L., and Montell, C. (2000). TRPgamma, a drosophila TRP-related subunit, forms a regulated cation channel with TRPL. Neuron 26, 647-657. 



Chang, C.C., Warren, D.S., Sacksteder, K.A., and Gould, S.J. (1999). PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import. J Cell Biol 147, 761-774.

Geisbrecht, B.V., and Gould, S.J. (1999). The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase. J Biol Chem 274, 30527-30533.

Geisbrecht, B.V., Liang, X., Morrell, J.C., Schulz, H., and Gould, S.J. (1999). The mouse gene PDCR encodes a peroxisomal delta(2), delta(4)-dienoyl-CoA reductase. J Biol Chem 274, 25814-25820.

Liu, Y., Bjorkman, J., Urquhart, A., Wanders, R.J., Crane, D.I., and Gould, S.J. (1999). PEX13 is mutated in complementation group 13 of the peroxisome-biogenesis disorders. Am J Hum Genet 65, 621-634.

Liu, Y., and Montell, D.J. (1999). Identification of mutations that cause cell migration defects in mosaic clones. Development 126, 1869-1878. Ma, L., Xu, J., Coulombe, P.A., and Wirtz, D. (1999). Keratin filament suspensions show unique micromechanical properties. J Biol Chem 274, 19145-19151.

Ma, L., Xu, J., Coulombe, P.A., and Wirtz, D. (1999). Keratin filament suspensions show unique micromechanical properties. J Biol Chem 274, 19145-19151. 



Geisbrecht, B.V., Collins, C.S., Reuber, B.E., and Gould, S.J. (1998). Disruption of a PEX1-PEX6 interaction is the most common cause of the neurologic disorders Zellweger syndrome, neonatal adrenoleukodystrophy, and infantile Refsum disease. Proc Natl Acad Sci U S A 95, 8630-8635.

Xu, X.Z., Choudhury, A., Li, X., and Montell, C. (1998). Coordination of an array of signaling proteins through homo- and heteromeric interactions between PDZ domains and target proteins. J Cell Biol 142, 545-555.

Xu, X.Z., Wes, P.D., Chen, H., Li, H.S., Yu, M., Morgan, S., Liu, Y., and Montell, C. (1998). Retinal targets for calmodulin include proteins implicated in synaptic transmission. J Biol Chem 273, 31297-31307.  



Chang, C.C., Lee, W.H., Moser, H., Valle, D., and Gould, S.J. (1997). Isolation of the human PEX12 gene, mutated in group 3 of the peroxisome biogenesis disorders. Nat Genet 15, 385-388.

Xu, X.Z., Li, H.S., Guggino, W.B., and Montell, C. (1997). Coassembly of TRP and TRPL produces a distinct store-operated conductance. Cell 89, 1155-1164. 






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