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Helicobacter Status of JHU Facilities

Helicobacter NEGATIVE: BRB suite 17; CRB NOD SCID room; transgenic core; individual designated and posted racks in other facilities
Helicobacter POSITIVE: All other facilities except those mentioned above.


How many Helicobacters infect mice?

There are multiple species of Helicobacter that infect mice. The first to be published, and the most pathogenic is H hepaticus. However, there are many other mouse Helicobacters, several of which have a documented research impact including chronic intestinal inflammation, hepatitis and liver tumors.

How do we test for Helicobacter?

We test for Helicobacters by PCR of fecal samples (in-house generic test). We test Helicobacter-negative facilities routinely through the sentinel program and by testing ventilated rack exhaust by PCR. Individual cages can be tested by request on a fee-for-service basis.

Can I move my mice that I received from another institution to a Helicobacter negative facility?

We will test your mice twice in quarantine. If both test are negative, you may request a transfer to a negative facility.

What can we do if we want Helicobacter negative mice?

We have shown that a commercial 4-drug diet can eliminate helicobacter infections from the vast majority of mouse strains, including those with deficiencies in innate and adaptive immunity. Cross fostering to a Helicobacter negative dam at 24h has also proven successful. Please consult Julie Watson for further information.