Helicobacter NEGATIVE: BRB suite 17; CRB NOD SCID room; transgenic core; individual designated and posted racks in other facilities
Helicobacter POSITIVE: All other facilities except those mentioned above.
- How many Helicobacters infect mice? There are multiple species of Helicobacter that infect mice. The first to be published, and the most pathogenic is H hepaticus. However, there are at least 6 other mouse Helicobacters, several of which have a documented research impact including chronic intestinal inflammation, hepatitis and liver tumors.
- How do we test for Helicobacter? We test for Helicobacters by PCR of fecal samples. We test Helicobacter-negative facilities routinely through the sentinel program. Others on request on a fee for service basis.
- Can I move my mice that I recieved from another institution to a Helicobacter negative facility? We will test your mice twice in quarantine. If both test are negative, you may request a transfer to a negative facility.
- What can we do if we want Helicobacter negative mice? We have shown that a commercial 4-drug diet can eliminate helicobacter infections from the vast majority of mouse strains, inclduing those with deficiencies in innate and adaptive immunity. Cross fostering to a Helicobacter negative dam at 24h has also proven successful. Please consult Julie Watson for further information.