Helicobacter Status of JHU Facilities (updated September 2010)
Helicobacter NEGATIVE: BRB suite 17 and 16 (C,D), parts of CRB2 and CRB1, transgenic core; individual designated and posted racks in other facilities
Helicobacter POSITIVE: All other facilities except those mentioned above.
- How many Helicobacters infect mice? There are multiple species of Helicobacter that infect mice. The first to be published, and the most pathogenic is H hepaticus. However, there are at least 6 other mouse Helicobacters, several of which have a documented research impact including chronic intestinal inflammation, hepatitis and liver tumors.
- How do we test for Helicobacter? We test for Helicobacters by PCR of fecal samples (in-house generic test). We test Helicobacter-negative facilities routinely through the sentinel program. Others on request on a fee for service basis.
- Can I move my mice that I recieved from another institution to a Helicobacter negative facility? We will test your mice twice in quarantine. If both test are negative, you may request a transfer to a negative facility.
Helicobacter and CRB
- How do we monitor Helicobacter status in CRB 1 and 2? Sentinels are tested every 4 months by PCR.
- What is the Helicobacter status of CRB 1 and 2? Many rooms are posted Helicobacter negative.
- What can we do if we want Helicobacter negative mice? There is currently a cross-fostering program in place to rederive infected animals in CRB.