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Helicobacter Status of JHU Facilities (updated May 2015)
- Helicobacter NEGATIVE: MRB suite 17, transgenic core; individual designated and posted racks in other facilities
- Helicobacter POSITIVE: All other facilities except those mentioned above.
How many Helicobacters infect mice?
There are multiple species of Helicobacter that infect mice. The first to be published, and the most pathogenic is H hepaticus. However, there are many other mouse Helicobacters, several of which have a documented research impact including chronic intestinal inflammation, hepatitis and liver tumors.
How do we test for Helicobacter?
We test for Helicobacters by PCR of fecal samples (in-house generic test). We test Helicobacter-negative facilities routinely through the sentinel program and by testing ventilated rack exhaust by PCR. Individual cages can be tested by request on a fee-for-service basis.
Can I move my mice that I received from another institution to a Helicobacter negative facility?
We will test your mice twice in quarantine. If both test are negative, you may request a transfer to a negative facility.
Can we treat our existing mice to remove Helicobacters?
In most cases, yes. A 4-drug treatment diet has proven successful in completely eliminating rodent helicobacters in over 90% of attempts, including in mice with innate or adaptive immune deficiencies. For more information contact Julie Watson.
Are mice purchased from vendors free of Helicobacters spp.?
Yes. All the major vendors provide Helicobacter-free mice to JHU.