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School of Medicine
Helicobacter Status of JHU Facilities (updated May 2015)
- Helicobacter NEGATIVE: MRB suite 17, transgenic core; individual designated and posted racks in other facilities
- Helicobacter POSITIVE: All other facilities except those mentioned above.
- How many Helicobacters infect mice? There are multiple species of Helicobacter that infect mice. The first to be published, and the most pathogenic is H hepaticus. However, there are many other mouse Helicobacters, several of which have a documented research impact including chronic intestinal inflammation, hepatitis and liver tumors.
- How do we test for Helicobacter? We test for Helicobacters by PCR of fecal samples (in-house generic test). We test Helicobacter-negative facilities routinely through the sentinel program and by testing ventilated rack exhaust by PCR. Individual cages can be tested by request on a fee-for-service basis.
- Can I move my mice that I received from another institution to a Helicobacter negative facility? We will test your mice twice in quarantine. If both test are negative, you may request a transfer to a negative facility.
- Can we treat our exisiting mice to remove Helicobacters? In most cases, yes. A 4-drug treatment diet has proven successful in completely eliminating rodent helicobacters in over 90% of attempts, including in mice with innate or adaptive immune deficiencies. For more information contact Julie Watson.
- Are mice purchased from vendors free of Helicobacters spp.? Yes. All the major vendors provide Helicobacter-free mice to JHU.