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In the department of Anesthesiology and Critical Care Medicine, the faculty explore a wide breadth of topics in basic and applied pulmonary pathophysiology, on scales ranging from the gene to the whole organism. Major areas of research include the molecular biology and genetics of pulmonary vascular reactivity; pulmonary endothelial and epithelial roles in acute lung injury; the biology and mechanics of airway constriction; ischemia-reperfusion injury; functional lung imaging with computed tomography and magnetic resonance imaging; regional genomics and cellular responses in acute lung injury; lung mechanics and optimal mechanical ventilation approaches in acute lung injury; lung mechanical impedance and distributed computational models of lung mechanics; surfactant rescue in lung injury; interactions between the lung and distant organs; and novel forms of mechanical ventilation, including high-frequency oscillatory ventilation. We have expertise in small- and large-animal models of lung disease, as well as in cellular and molecular approaches. In addition, our faculty have significant roles in institutional programs, including Specialized Centers of Clinically Oriented Research (SCCOR) grants in acute lung injury, pulmonary hypertension, and chronic obstructive pulmonary disease, and international collaborations in physiological imaging and modeling. These basic science efforts link with clinical and translational research in adult and pediatric patients.
Brown, Robert – Professor. Research Focus: studying the structure?function relationship of pulmonary airways and vessels and how it relates to reactive airway disease and chronic obstructive pulmonary disease. PULMONARY
Chang, Fumin – (Lab: Nick Flavahan) Research Associate. CARDIOVASCULAR, PULMONARY
Dodd-o, Jeff – Associate Professor. Research Focus: understanding the factors that contribute to ischemia/reperfusion injury of the lung and how ischemia/reperfusion contributes to lung dysfunction in the early post-cardiopulmonary bypass period. PULMONARY
Flavahan, Nick – Professor. Research Focus: elucidating the cellular interactions and subcellular signaling pathways that control normal vascular function and regulate the initiation of vascular disease. CARDIOVASCULAR, PULMONARY
Heller, Nikki – Assistant Professor. Research Focus: IL-4/IL-13 receptor signaling and function and macrophage biology in allergic disease. PULMONARY
Johns, Roger – Professor. Research Focus: investigating the mechanisms that underlie anesthesia, analgesia, chronic pain, and inflammatory lung disorders (such as pulmonary hypertension and asthma). CARDIOVASCULAR, PAIN, PULMONARY
Yamaji-Kegan, Kazuyo – Assistant Professor. Research Focus: Pulmonary vascular angiogenesis, vasculogenesis, and inflammation using in vivo physiology, in vitro cell biology, and genetic and biochemical approaches. PULMONARY
Romer, Lew – Professor, Departments of Anesthesiology/Critical Care Medicine, Cell Biology, Biomedical Engineering, Pediatrics, Cell and Molecular Medicine Program, Center for Cell Dynamics. CARDIOVASCULAR, PULMONARY