Department of Anesthesiology/Critical Care Medicine
The Johns Hopkins University School of Medicine
720 Rutland Avenue, Ross 370B
Baltimore, MD 21205
The research of Dr. Jian Wang focuses on understanding the pathophysiology of intracerebral hemorrhage (ICH). He uses established preclinical models of hemorrhagic stroke, including the collagenase-induced model and the autologous whole blood model to search for endogenous proteins as well as potential drugs to prevent or alleviate neuropathic injury. He is also interested in translational research to identify potential therapeutic targets to treat or limit hemorrhagic brain injury, including complementary and alternative medicines. He has ongoing projects supported by the American Heart Association and the National Institutes of Health.
Dr. Wang has extensive experience in the study of matrix metalloproteinases (MMPs) and heme oxygenases. He previously demonstrated that MMP-9 is activated and upregulated after ICH and that its inhibition may be neuroprotective and lead to improved outcomes. This exciting work has been published in the highly regarded journal Brain. Recently, he developed an interest in studying the role of prostaglandin E2 (PGE2) receptors after ICH in the aging brain to determine if there is a direct link between PGE2 and MMP-9 induction in ICH. He plans to combine his previous research experience and knowledge of MMPs with the recently characterized roles of the respective PGE2 receptors in ICH.
- American Heart and Stroke Association
- American Society for Neuroscience
- International Society for Cerebral Blood Flow & Metabolism
- Wang J, Tsirka SE. Neuroprotection by inhibition of matrix metalloproteinases in a mouse model of intracerebral hemorrhage. Brain 128:1622–33, 2005.
- Wang J, Doré S. Heme oxygenase-1 exacerbates early brain injury after intracerebral hemorrhage. Brain 130:1643–52, 2007.
- Wu H, Zhang Z, Hu X, Zhao R, Song Y, Ban X, Qi J, Wang J. Dynamic changes of inflammatory markers in brain after hemorrhagic stroke in humans: a postmortem study. Brain Res 1342:111–7, 2010.
- Wu H, Li Y, Zhao R, Li H, Song Y, Qi J, Wang J. Time course of upregulation of inflammatory mediators in the hemorrhagic brain in rats: correlation with brain edema. Neurochem Int 57:248–53, 2010.
- Wang J. Preclinical and clinical research on inflammation after intracerebral hemorrhage. Prog Neurobiol 92:463–77, 2010.
- Wu H, Wu T, Xu X, Wang J, Wang J. Iron toxicity in mice with collagenase-induced intracerebral hemorrhage. J Cereb Blood Flow Metab Nov 24, 2010 [Epub ahead of print].
Current Laboratory Members/Key Associates
Weizhu Tang, MS
He Wu, MD, PhD
Jessica Wang, Undergraduate student
Mali Wiederkehr, Undergraduate student
Tao Wu, MD, PhD
- American Heart Association Postdoctoral Fellowship (2002–2004)
- American Heart Association Scientist Development Grant (2006–2008)