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Departments of Anesthesiology/Critical Care Medicine and Neurological Surgery
The Johns Hopkins University School of Medicine
600 North Wolfe Street, Meyer 8-140
Baltimore, MD 21287-7840
Dr. Paul Nyquist has an ongoing interest in any translational research project that incorporates well-founded biologic models into patient care in brain injury. He has been involved in a number of clinical trials that have been at the forefront of new technologic innovations in brain injury and has extensive experience in clinical trials in both military and civilian settings. These trials often have involved protocols with high clinical impact on those enrolled.
Dr. Nyquist also has a theoretical focus that emphasizes the role of inflammation in cerebrovascular disease, with particular attention to the effects of inflammation on endothelial activation. He is interested in how inflammation and endothelial activation affect the neurovascular unit. To that end, he is investigating the role of genetic variation on the proclivity of the endothelium to become transformed into a procoagulant state in carotid atherosclerosis.
Using extensive clinical testing for commonly detected risk factors in cerebral vascular disease, Dr. Nyquist is exploring how cerebrovascular small-vessel disease in patients who are predisposed to atherosclerosis may be influenced by inflammation and genetic history. He is also investigating how biomarkers may be used to detect damage in each compartment of the neurovascular unit in the settings of vasospasm and cerebral salt wasting in patients with subarachnoid hemorrhage.
Dr. Nyquist believes that an interrelationship exists between small-vessel disease of the brain and small-vessel disease of the heart and that a number of potential genes may predispose to both. In a study that he conducted in a group of patients who had asymptomatic small-vessel disease of the heart, he found a cross-correlation with silent small-vessel strokes in the brain. His goal is to identify the genes that are associated with cerebral vascular disease in the hopes of developing new treatments for this condition that afflicts millions worldwide.
- American Academy of Neurology
- Society of Critical Care Medicine
- Neuro Critical Care Society
- American Heart Association
- Stroke Council
- Alpha Omega Alpha
- Toung TJ, Nyquist P, Mirski MA. Effect of hypertonic saline concentration on cerebral and visceral organ water in an uninjured rodent model. Crit Care Med 36(1):256–61, 2008.
- Nyquist P, LeDroux S, Geocadin R. Thrombolytics in intraventricular hemorrhage. Curr Neurol Neurosci Rep 7(6):522–8, 2007.
- Nyquist P, Ball R, Sheridan MJ. Complement levels before and after dives with a high risk of DCS. Undersea Hyperb Med 34(3):191–7, 2007.
- Lee AW, Chen CS, Gailloud P, Nyquist P. Wyburn-mason syndrome associated with thyroid arteriovenous malformation: a first case report. AJNR Am J Neuroradiol 28(6):1153–4, 2007.
- Nyquist P, Hanley DF. The use of intraventricular thrombolytics in intraventricular hemorrhage. J Neurol Sci 261(1–2):84–8, 2007.
Laboratory Members/Key Associates
Taryn Moy, MS
Shanon Ledroux, BSc
Diane Becker, PhD, and Lewis Becker MD, PhD, JHU Department of Medicine
Rafael Tamargo, MD, JHU Department of Neurosurgery
Anthony Sufferedini, MD, NIH Intramural program, Critical Care Medicine Department
Mark Gladwin, MD, NIH Intramural Vascular Program, National Institute of Heart Lung and Blood
Dan Hanely, MD, Brain Injury Outcomes group, JHU School of Medicine
Cheryl Winkler, PhD, National Cancer Institute
An Ping, PhD, National Cancer Institute
Andrew P. Levy, MD, PhD, Technion–Israel Institute of Technology, Department of Medicine
Dr. Nyquist is affiliated with the Siblings and Family Heart Study
- United Nations Humans Rights Community Award, United Nations Association of The National Capital Area: For care of victims of torture in the Washington, DC, area (2003)
- American Neurological Association, travel fellow award (2001)
- General Loan Repayment Program, National Institute of Health (2000–2003)
- American Epilepsy Society, Young Investigators Award (1999)
- Navy and Marine Corps Commendation Medal (1996)
- Alpha Omega Alpha, GWU Medical School (1992)
- Navy Health Professional Scholarship (1989)