Professor of Anesthesiology and Critical Care Medicine
Department Chairman and Director of Clinical Research
Johns Hopkins Medicine Bayview Medical Center
4940 Eastern Avenue
Baltimore, Maryland 21224
Appointment Phone: 410-955-8408
The research of Dr. Frederick (Fritz) Sieber focuses on problems specific to geriatric surgical patients and on optimization of their surgical outcomes. Through multidisciplinary clinical research, he studies elderly surgical patients, especially those undergoing orthopedic procedures. At the Johns Hopkins Bayview Medical Center, a multidisciplinary Hip Fracture Service has been ongoing since the late 1990s. The service includes Anesthesiology (Dr. Sieber and Mary-Rita Blute, RN, MS), Orthopaedics (Drs. Simon Mears and Tariq Nayfeh), Geriatrics (Dr. Jeremy Walston), and Neuropsychiatry (Drs. Constantine Lyketsos, Benjamin Lee, and Paul Rosenberg). Several members of the Hip Fracture Service have funded clinical research projects. Dr. Mears, for example, has a grant from the Orthopaedic Trauma Association to study inflammatory markers of delirium in elderly surgical patients who have had a repair of a traumatic hip fracture or who have had an elective hip replacement. Dr. Mears and the Anesthesiology team collect perioperative cerebrospinal fluid and blood samples from these patients to measure inflammatory and dementia markers and their possible relationships to postoperative delirium. Second, an NIH-funded multi-center trial is investigating whether the sedative dexmedetomidine attenuates postoperative delirium and cognitive dysfunction in elderly surgical patients. Dr. Sieber is the Hopkins principal investigator for this trial. Third, in another NIH-funded clinical trial, Dr. Sieber and his Anesthesiology team are researching the effects of depth of sedation (as measured by the BIS monitor and the OAA/S score) during regional anaesthesia with propofol on the incidence of postoperative delirium, cognitive dysfunction, and mortality in elderly hip fracture patients.