Department of Anesthesiology and Critical Care Medicine
The Johns Hopkins University School of Medicine
600 N. Wolfe Street, Wilmer 340
Baltimore, MD 21287
Dr. Dodd-o’s experiences as a cardiac anesthesiologist and his work with heart and lung transplantation patients in the cardiac surgical intensive care unit led him to his chosen path of scientific investigation. His principle research efforts are engaged in understanding the factors that contribute to ischemia/reperfusion injury of the lung and the contribution of ischemia/reperfusion to the lung dysfunction seen in patients in the early post-cardiopulmonary bypass period. To this end, he has developed a sensitive model of ischemia/reperfusion in a spontaneously breathing mouse. He is using this model and an in situ mouse lung preparation to identify cardiopulmonary interactions that affect lung injury caused by reperfusion. As an example, Dr. Dodd-o and his colleagues are attempting to characterize the influence on lung microvascular permeability of atrial natriuretic peptide (ANP), which is secreted by the heart. Their preliminary observations indicate that ANP is sometimes injurious and sometimes protective to the lung, and they are working to determine the factors that alter its influence on lung permeability.
In another area of study, Dr. Dodd-o is utilizing various preclinical models to begin to explore the influences of mechanical ventilation on lung injury and kidney function, as well as the interaction of mechanical ventilation and kidney injury on lung function.
Dr. Dodd-o’s long-term goal is to use a mouse lung transplantation model to distinguish immunologic effects from reperfusion effects on graft survival. Lung inflammation can be caused by rejection; it can also be caused by reperfusion. With models of both, Dr. Dodd-o hopes to distinguish which aspects of lung injury following transplantation are due to reperfusion and which are immunologically mediated.