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Cardiac Anesthesia Team

Dan E. Berkowitz, MBBCh

Dan E. Berkowitz, MD
Chief, Division of Cardiac Anesthesia
Professor of Anesthesiology and Critical Care Medicine
Professor of Biomedical Engineering

The work of Dr. Daniel Berkowitz is probably as close to rocket science as an anesthesiologist is going to get. Dr. Berkowitz is trying to understand the mechanisms that underlie vascular disorders, but one of his main concentrations is the effect of deep space radiation on the cardiovascular system. In space, astronauts are exposed to dangerous levels of high-energy radiation. Therefore, NASA and the National Space Biomedical Research Institute are funding Dr. Berkowitz to determine not only the damage that such energy causes, but what interventions or therapeutics could be used to reverse the damage.

Radiation can cause cells in the body to produce dangerous molecules known as oxidants. Because oxidants are known to damage DNA, in the past, radiation exposure was investigated mostly as a cancer risk. But the cells that line our blood vessels (endothelial cells) are also highly vulnerable to oxidant damage. To learn more about this phenomenon, Dr. Berkowitz and his graduate student Kevin Soucy are conducting experiments at the Brookhaven National Laboratory near Stony Brook, New York, where they have access to a particle accelerator, which creates radiation similar to what astronauts could encounter. In pre-clinical studies, Dr. Berkowitz and his team use the radiation produced to examine its effects on vascular stiffness and endothelial cell function.

Dr. Berkowitz believes that the high-energy radiation activates an enzyme called xanthine oxidase (XO) and that XO is responsible for maintaining a chronic cycle of oxidant production. He thinks that the use of an XO inhibitor can interrupt this cycle of stress to the cells and thereby limit the damage. This ability to target the XO enzyme could have additional applications, such as for patients who need radiotherapy or in the event of a terrorist attack. In the long term, he hopes to uncover the molecular mechanisms responsible for cardiovascular injury as well as natural pathways of repair.

Dr. Berkowitz is a man who clearly enjoys his work. He says that he loves testing hypotheses associated with basic cellular mechanisms and discovering how these processes are altered in various disease states. What’s more, he likes to teach his students how to think about disease processes in these terms and how to apply basic science to clinical problems. Dr. Berkowitz asserted that the work that he and his students are doing now will be highly valuable when we establish colonies on the moon and send astronauts to Mars. Notice that he said when, not if.

Charles Brown, MD

Charles Brown, MD
Assistant Professor of Anesthesiology and Critical Care Medicine

Dr. Charles Brown is an assistant professor of anesthesiology and critical care medicine at the Johns Hopkins University School of Medicine. His area of clinical expertise is cardiac anesthesia.

Dr. Brown received his undergraduate degree from Harvard University. He earned his M.D. at the Johns Hopkins School of Medicine. He also completed a residency in emergency medicine, a residency in anesthesiology and a fellowship at Johns Hopkins.

His research interests include quality and outcomes regarding perioperative management of older adults, specifically focused on post-operative delirium, cognitive change and transfusion practices.

Dr. Brown received a two-year Research Career Development Core Award from the NIH-funded Johns Hopkins Claude D. Pepper Older Americans Independence Center. The award supports ongoing research on how baseline frailty in cardiac surgery patients affects postoperative delirium and functional change in older adults, along with potential interventions.

Nauder Faraday, MD

Nauder Faraday, MD
Professor of Anesthesiology and Critical Care Medicine

Dr. Nauder Faraday is a professor of anesthesiology and critical care medicine at the Johns Hopkins University School of Medicine. His areas of clinical expertise include cardiac anesthesia and surgical intensive care. He serves as director of Perioperative Genomic and Translational Research and director of the Perioperative Hemostasis and Thrombosis Research Laboratory for the Department of Anesthesiology and Critical Care Medicine.

After receiving his undergraduate degree from Columbia University, Dr. Faraday earned his medical degree from Mount Sinai School of Medicine. He completed an internship at the Hospital of St. Raphael at Yale University and a residency in anesthesiology at Johns Hopkins University School of Medicine. He performed fellowships in critical care medicine and cardiovascular anesthesiology, as well as two research fellowships, at Johns Hopkins. Recently, he earned a Master of Public Health degree from the Johns Hopkins Bloomberg School of Public Health. Dr. Faraday joined the Johns Hopkins faculty in 1993.

Since 2008, Dr. Faraday has worked to build a research program in perioperative genetic and molecular medicine. His goal is to identify molecular determinants of complications of surgery.

He serves as an ad hoc reviewer for a number of journals and is a member of the Society of Cardiovascular Anesthesiologists, the Society of Critical Care Medicine and the International Anesthesia Research Society, among others. He was recognized as a Marquis Who’s Who in Medicine and Healthcare in 2011.

Jochen Steppan, MD, DESA

Jochen Steppan, MD, DESA
Assistant Professor of Anesthesiologyand Critical Care Medicine

Dr. Jochen Steppan is an assistant professor of anesthesiology and critical care medicine at the Johns Hopkins University School of Medicine. He specializes in adult cardiothoracic anesthesiology. Dr. Steppan completed his M.D. at the Ruprecht Karls University in Heidelberg, Germany. He conducted residencies in anesthesiology at the UniversitDr. Jochen Steppan is an assistant professor of anesthesiology and critical care medicine at the Johns Hopkins University School of Medicine. He specializes in adult cardiothoracic anesthesiology.

Dr. Steppan completed his M.D. at the Ruprecht Karls University in Heidelberg, Germany. He conducted residencies in anesthesiology at the University Hospital of Heidelberg and the Johns Hopkins University School of Medicine. Additionally, he completed fellowships in anesthesiology and critical care medicine, adult cardiothoracic anesthesiology and pediatric cardiac anesthesiology at Johns Hopkins. His research focuses on vascular stiffness, an important predictor of aging associated cardio-vascular morbidity. Dr. Steppan is a member of the American Heart Association, the International Anesthesia Research Society, the American Society of Anesthesiologists, the Society for Cardiovascular Anesthesiologists and the German Medical Society for Acupuncture. He has published extensively and has won several awards for his research. He is certified by the American Board of Anesthesiology. y Hospital of Heidelberg and the Johns Hopkins University School of Medicine. Additionally, he completed fellowships in anesthesiology and critical care medicine, adult cardiothoracic anesthesiology and pediatric cardiac anesthesiology at Johns Hopkins.

His research focuses on vascular stiffness, an important predictor of aging associated cardio-vascular morbidity.

Dr. Steppan is a member of the American Heart Association, the International Anesthesia Research Society, the American Society of Anesthesiologists, the Society for Cardiovascular Anesthesiologists and the German Medical Society for Acupuncture. He has published extensively and has won several awards for his research. He is certified by the American Board of Anesthesiology.

 
 

Anesthesiology Events


Discovery and Innovation Calendar

Anesthesiology Grand Rounds

ACCM Grand Rounds take place Thursdays at 7 AM in Hurd Hall. Windows Media Player is required to view webcasts.

Third Annual Mark C. Rogers Endowed Lectureship – Joseph Stauffer, DO, MBA
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8/4: Paco Herson, MD
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8/11: Marjorie Stiegler, MD
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8/18: Ling Hu, MD
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State of the Department – Colleen Koch, MD, MS, MBA, FACC, Director
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2016 Donald W. and Marjorie Benson Lectureship on Pain Medicine – Tony Yaksh, MD
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