John A. Ulatowski, M.D., Ph.D., M.B.A.
Director, The Johns Hopkins Medical Institutions Department of Anesthesiology & Critical Care Medicine

Major research interest is in regulatory mechanisms of cerebral blood flow and oxygen delivery to brain under normal and pathological states. Active areas of work involve the study of the effects of oxygen carriers (blood substitutes) on these variables in normal brain, under conditions of hypoxia, and in animal models of global and focal cerebral ischemia. Another major interest is in the development of techniques to measure cerebral blood flow and state of cerebral oxygenation of brain tissue non-invasively using magnetic resonance imaging and spectroscopy. Clinical research interests include 1) development and application of non-invasive techniques of monitoring brain function in the ICU (Doppler, EEG, cardiac variability, MR spectroscopy), 2) fluid management in the brain injured patient (mannitol, hypertonic saline), 3) sedation of the brain injured patient, and new techniques and therapies for stroke (thrombolysis, angioplasty, pharmacological neuroprotective agents). Peripheral interest in diving physiology and medicine.

My clinical responsibilities include providing care in most areas of the hospital but my emphasis is in neurosurgical anesthesiology and neuroscience critical care medicine, and vascular-thoracic anesthesiology.

Publications

• Davis, D., J.A. Ulatowski, , S. Eleff, M. Izuta, S. Mori, D. Shungu, P.C.M. Van Zijl. Rapid monitoring of changes in water diffusion coefficients during reversible ischemia in cat and rat brain. Magnetic Resonance in Medicine 31:454-460, 1994.
  
• Ulatowski, J.A., J.R. Kirsch and R.J. Traystman 1994. Hypoxic reperfusion after ischemia in swine does not improve brain recovery. Am. J. Physiol. 267 (Heart Circ. Physiol. 36) :H1880-1887, 1994.
  
• Ulatowski, J.A., R.C. Koehler, T. Nishikawa, R.J. Traystman, A. Razynska, H. Kwansa, B. Urbaitis, and E. Bucci. Role of nitric oxide scavenging in peripheral vasoconstrictor response to §§ cross-linked hemoglobin. Artificial Cells, Blood Substitutes and Immobilization Biotechnology 23:263-269, 1995.
  
• Mirski, M.A., B. Muffelman, J.A. Ulatowski, and D.F. Hanley. Sedation for the critically ill neurological patient. Critical Care Medicine 23:2038-2053, 1995.
  
• Tietjen, C.S., P.D. Hurn, J.A. Ulatowski, J.R. Kirsch. Treatment modalities for hypertensive patients with intracranial pathology: Options and risks. Critical Care Medicine. Critical Care Medicine 24:311-322, 1996.
  
• Ulatowski, J.A., E. Bucci, R.C. Koehler, T. Nishikawa, B. Urbaitis, A. Razynska, M.A. Williams, R. Takeshima, and R.J. Traystman. Cerebral O2 transport with hematocrit reduced by crosslinked hemoglobin transfusion. Am. J. Physiol. 270:H466-H475, 1996.
  
• Becker, K.J., L.H. Monsein, J.A. Ulatowski, M.A. Mirski, M.A. Williams, and D.F. Hanley. Intra-arterial thrombolysis in vertebrobasilar occlusion. Am. J. Neuroradiology. 17:255-262, 1996.
  
• Ulatowski, J.A., E. Bucci, T. Nishikawa, B.K. Urbaitis, R.J. Traystman and R.C. Koehler. Regional blood flow alterations after bovine fumaryl §§-crosslinked hemoglobin transfusion and nitric oxide synthase inhibition. Critical Care Medicine 24:558-565, 1996.
  
• Bucci, E., A. Ryzynska, Herman Kwansa, B. Matheson-Urbaitis, M. O'Hearne, J.A. Ulatowski and R.C. Koehler. Production and characteristics of an infusible oxygen carrying fluid based on hemoglobin intra molecularly cross linked with sebacic acid. J. Lab. Clin. Med. 128:146-153, 1996.
  
• Kauppinen, R.A., S.M. Eleff, J.A. Ulatowski, M. Kraut, B. Soher, P.C.M. van Zijl. Visual activation in a-chloralose-anesthetized cats does not cause lactate accumulation in the visual cortex as detected by [1H]NMR difference spectroscopy. Eur. J. Neuroscience 9:654-661, 1997.
  
• Qureshi, A.I., J.I. Suarez, P.D. Parekh, G. Sung, R. Geocadin, A. Bhardwaj, R.J. Tamargo, J.A. Ulatowski. Risk factors for multiple intracranial aneurysms. Neurosurgery 43(1):22-6; discussion 26-7, 1998.
  
• Qureshi, AI, M.A. Choudhry, M.S. Akbar., Y. Mohammad, HC Chua, A.M. Yahia, J.A. Ulatowski, D.A. Krendel, and R.T. Leshner. Plasma exchange versus intravenous immunoglobulin treatment in myasthenic crisis. Neurology 52(3):629-32, 1999.
  
• Ulatowski, J.A., J.M.E. Oja, J.I. Suarez, R.A. Kauppinen, R.J. Traystman, and P.C.M. van Zijl. In Vivo Determination of Absolute Cerebral Blood Volume Using Hemoglobin as a Natural Contrast Agent: An MRI Study Using Altered Arterial Carbon Dioxide Tension. Journal of Cerebral Blood Flow and Metabolism, 19:809-817, 1999.
  
• Suarez JI, Qureshi IA, Parekh PD, Razumovsky A, Tamargo RJ, Bhardwaj A and Ulatowski JA: Administration of Hypertonic (3%) Sodium Chloride/Acetate in Hyponatremic Patients with Symptomatic Vasospasm Following Subarachnoid Hemorrhage. Journal of Neurosurgical Anesthesiology, 11(3):178-184, 1999.
  
• Bhardwaj A and Ulatowski JA: Cerebral Edema: Hypertonic Saline Solutions. Current Treatment Options in Neurology, 1:179-187, 1999.
  
• Qureshi, A.I., J.I. Suarez, A. Bhardwaj, A.M. Yahia, R.J. Tamargo, J.A. Ulatowski. Early predictors of outcome in patients receiving hypervolemic and hypertensive therapy for symptomatic vasospasm after subarachnoid hemorrhage. Critical Care Medicine 28(3):824-829, 2000.
  
• Naff, N.J., J.R. Carhuapoma, M.A.Williams, A. Bhardwaj, J.A. Ulatowski, J. Bederson, R. Bullock, E. Schmutzhard, B. Pfausler, P.M. Keyl, S. Turhim and D.F. Hanley. Treatment of intraventricular hemorrhage with urokinase: effects on 30-Day survival. Stroke 31(4):841-847, 2000.