The Sawa Laboratory: Publications

Selected Publications

1. A. Kamiya, T. Tomoda, J. Chang, M. Takaki, C. Zhan, M. Morita, M.B. Cascio, S. Elashvili, H. Koizumi, Y. Takanezawa, F. Dickerson, R. Yolken, H. Arai, A. Sawa DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1. Hum Mol Genet. 15(22); 3313-23 (2006)
2. K. Ishizuka, M. Paek, A. Kamiya, A. Sawa A review of Disrupted-In-Schizophrenia-1 (DISC1): neurodevelopment, cognition, and mental conditions. Biol Psychiatry. 59(12); 1189-97 (2006)
3. B.I. Bae, M.R. Hara, M.B. Cascio, X. Luo, L.J. Hanle, C.A. Ross, J. Ha, X.J. Li, S.H. Snyder, A. Sawa Mutant Huntingtin: Nuclear translocation and cytotoxicity modulated by GAPDH. Proc. Natl. Acad. Sci. USA. 103(9); 3405-09 (2006)
4. M.R. Hara, B. Thomas, M.B. Cascio, A.S. Huang, S.K. Tankou, B.I. Bae, M.D. Kornberg, L.D. Hester, V.L. Dawson, T.M. Dawson, A. Sawa, and S.H. Snyder Neuroprotection by pharmacologic blockade of the GAPDH death cascade Proc. Natl. Acad. Sci. USA 103(10); 3887-89 (2006)
5. K. Fujii, K. Maeda, T. Hikida, A.K. Mustafa, R. Balkissoon, J. Xia, T.Yamada, Y. Ozeki, R. Kawahara, M. Okawa, R.L. Huganir, H. Ujike, S. H. Snyder and A. Sawa Serine racemase binds PICK1: potential relevance to schizophrenia. Mol. Psychiatry. 11(2); 150-57 (2006)
6. A. Kamiya, K. Kubo, T. Tomoda, M. Takaki, R. Youn, Y. Ozeki, N. Sawamura, U. Park, C Kudo, M. Okawa, C.A. Ross, M.E. Hatten, K. Nakajima, A. Sawa A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development. Nature Cell Biol., 7; 1167-78 (2005)
7. A. Sawa, S.H. Snyder Genetics. Two genes link two distinct psychoses. Science; 310; 1128-9 (2005)
8. B.I. Bae, S. Igarashi, M. Fujimuro, N. Agrawal, Y. Taya, S.D. Hayward, T. Moran, C.A. Ross, S.H. Snyder, A. Sawa p53 mediates cellular dysfunction and behavioral abnormalities in Huntington’s disease. Neuron 47; 29-41 (2005)
9. M.R. Hara, N. Agrawal, S.F. Kim, M.B. Cascio, M. Fujimuro, M. Takahashi, J.H. Cheah, S.K. Tankou, L.D. Hester, C.D. Ferris, S.D. Hayward, S.H. Snyder, A. Sawa S-Nitrosylated glyceraldehyde-3-phosphate dehydrogenase initiates cell death by nuclear translocation following Siah1 binding. Nature Cell Biol., 7; 665-674 (2005)
10. N.A. Sachs, A. Sawa, S.E. Holmes, C.A. Ross, L.E. DeLisi, R.L. Margolis A frameshift mutation in Disrupted in Schizophrenia 1 segregates with schizophrenia and schizoaffective disorder in an American family. Mol. Psychiatry, 10; 758-764 (2005)
11. N. Sawamura, T. Sawamura-Yamamoto, Y. Ozeki, C.A. Ross, and A. Sawa A form of DISC1 enriched in nucleus: Altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse. Proc. Natl. Acad. Sci. USA, 102; 1187-1192 (2005)
12. A. Sawa, M.V. Pletnikov, A. Kamiya, Neuron-glial interactions clarify genetic-environmental links in mental illness. Trends In Neuroscience 27; 294-297 (2004)
13. Y. Ozeki, T. Tomoda, J. Kleiderlein, A. Kamiya, L. Bord, K. Fujii, M. Okawa, N. Yamada, M. E Hatten, S.H. Snyder, C. A. Ross, A. Sawa Disrupted-In-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NUDEL and inhibits neurite outgrowth. Proc. Natl. Acad. Sci. USA, 100; 289-294 (2003)
14. A. Sawa, S.H. Snyder Schizophrenia: diverse approaches to a complex disease. Science, 296; 692-695 (2002)
15. H.R. Luo, A. Saiardi, E. Nagata, K. Ye, T.S. Jung, X. Luo, S. Jain, A. Sawa, S.H. Snyder GRAB: a physiologic guanine nucleotide exchange factor for Rab3A which interacts with inositol hexakisphosphate kinase. Neuron, 31; 439-451 (2001)
16. M. Fang, S.R. Jaffrey, A. Sawa, K. Ye, X. Luo, S.H. Snyder Dexras1; A G-protein specifically coupled to neuronal nitric oxide synthase via CAPON. Neuron, 28; 183-193 (2000)
17. C. D. Ferris, S.R. Jaffery, A. Sawa, M. Takahashi, S. Brady, R. K. Barrow, S. Tyosoe, H. Wolosker, S. Dore, S.H. Snyder Heme oxygenase-1 prevents cell death by regulating cellular iron levels. Nature Cell Biol., 1; 152-157 (1999)
18. A. Sawa, G.W. Wiegand, J.K. Cooper, R.L. Margolis, A.H. Sharp, J.E. Lawler, J.T. Greenamyre, S.H. Snyder, C.A. Ross Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization. Nature Med., 5; 1194-1198 (1999)