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Research Volunteers Needed

National Institute of Mental Health
A Participant's Guide to Mental Health Clinical Research
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ADHD |  | Addictions | AnorexiaAutism Bulimia | Eating Disorders | HEALTHY VOLUNTEERSMemory Disorders | Mood Disorders | Neurodevelopmental Disabilities | Obesity | Obsessive-Compulsive Disorder | Pain | Parkinson's Disease | Psychosis | SchizophreniaSleep Disorders | Substance Abuse - Addictions | Traumatic Brain Injury

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ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)

A Research Study to determine whether an investigational drug called Dasotraline is safe and effective to treat symptoms of Attention-Deficit/Hyperactivity Disorder
This research study is being conducted by Kennedy Krieger Institute/centers across the United States to determine the efficacy and safety of Dasotraline in male and female adults with Attention-Deficit Hyperactivity-Disorder (ADHD). If eligible, the participant will visit the Kennedy Krieger Institute up to 9 times over a period of 13weeks. Each visit will take about 2 to 4 hours and will include psychological and behavioral testing, medical history, physical examination, blood draws, vital sign, ECG, urine drug screen, and pregnancy testing for females. For each completed visit, participants will receive a reimbursement of $50.00 for their time and travel expenses.   Please ask a study team member for specifics.   All testing is done free of charge. For more information about this research study, please contact Victoria Osasah at (443) 923-3850 or by email at ResearchTrials@kennedykrieger.org PI: Robert Findling, M.D., M.B.A. Johns Hopkins Medicine-IRB No. – IRB00052924 ClinicalTrials.gov No.  NCT02160262 Study Sponsor: Sunovion Pharmaceuticals

Anomalous Motor Physiology in ADHD: Inhibitory and Reward Mechanisms – Ages 8-12
Dr. Stewart H. Mostofsky of the Kennedy Krieger Institute and Johns Hopkins School of Medicine is recruiting children with and without Attention Deficit Hyperactivity Disorder (ADHD) between 8 and 12 years of age to participate in a research study of attention, learning, memory, reward response, and motor skills.  The study involves paper and pencil tasks, computer activities, transcranial magnetic stimulation (TMS, a painless, non-invasive brain stimulation technique), an EEG, and a MRI scan of the brain. A single dose of medication that influences reward systems in the brain may also be given to your child.  None of the tests are harmful or painful and are done free of charge.  There are no direct medical benefits for participating in the study.  The duration of the study is one to two days. Participants will receive a $50 check for each day of study participation and a picture of their brain.  Parents will receive a report summarizing the IQ testing administered to their child.  For more information about this study, please contact Kristie Sweeney at (443) 923-9254 or LNIR@kennedykrieger.org.

Movement-Based Mindfulness Training for Children with ADHD: A Feasibility Study – Ages 8-12
Dr. Stewart H. Mostofsky of the Kennedy Krieger Institute and Johns Hopkins School of Medicine is recruiting children with Attention Deficit Hyperactivity Disorder (ADHD) between 8 and 12 years of age to participate in a study of behavior and brain function before and after movement-based Tai Chi training. The study involves paper and pencil tasks, computer activities, transcranial magnetic stimulation (TMS, a painless, non-invasive brain stimulation technique), an EEG and Tai Chi sessions. None of the tests are harmful or painful and are done free of charge. There are no direct medical benefits for participating in the study. The duration of the study is two days, with 8 weeks of Tai Chi classes in between. Participants will receive a $100 check and free Tai Chi classes. Parents will receive a report summarizing the IQ testing administered to their child. For more information about this study, please contact Mary Martinelli at (443) 923-9258 or Kristie Sweeney at (443) 923-9254 or LNIR@kennedykrieger.org.

Children With and Without ADHD - Ages 8–12 - Neurology of Deficient Response Control in ADHD-- (MRI Research Study of Executive Functioning)
Dr. Stewart Mostofsky and colleagues at the Laboratory of Neurocognitive and Imaging Research at Kennedy Krieger Institute are recruiting children between the ages of 8 and 12 years to participate in a research study of attention, response planning and inhibitory control.  This study is examining the brain basis of ADHD in children. We are looking for boys and girls with ADHD as well as children who do not have ADHD to participate as “comparison subjects”.  The study involves paper and pencil tasks, computer activities and a Magnetic Resonance Imaging (MRI) of the brain. None of these tests are harmful or painful.  There are no direct medical benefits from taking part in the study.  The study involves two days of testing and MRI.  Participants will receive $100.00 and a picture of their brain.  Parents will receive a report of the IQ test administered to their child.  All testing is done free of charge. For more information about this study, please contact Mary Martinelli at 443-923-9258 or Kristie Sweeney at (443) 923-9254 or by email LNIR@kennedykrieger.org.  (IRB protocol #NA_00027428)

Children With and Without ADHD - Ages 4–5
Dr. Mark Mahone and colleagues at the Kennedy Krieger Institute are recruiting children 4 or 5 years old to participate in a research study on learning and brain development in young children. We are looking for boys and girls with and without signs ADHD. The study involves two 3-hour visits of IQ, language, and behavioral tests, a Magnetic Resonance Imaging (MRI) scan of the brain, and behavioral practice sessions for MRI. None of these tests are harmful or painful. All testing is done free of charge. Participants receive a free summary of developmental testing, a picture of your child’s brain, and $50.00. For more information about this study, please contact Lisa Ferenc at (443) 923-4469 or by email (ferenc@kennedykrieger.org). Click here for a flyer. (IRB protocol #NA_00012868)  Download Flyer

Adult ADD/ADHD
Men and women who have been diagnosed with ADD or ADHD are needed for a 2-day outpatient study at the Johns Hopkins School of Medicine in Baltimore, Maryland. Volunteers with ADHD who have used medications for the treatment of ADHD and those who have never used medications for the treatment of ADHD are needed. Volunteers should be between the ages of 18 and 40 and in general good health. Testing will take place at the Johns Hopkins Hospital and Bayview Medical Center. Study participants will receive compensation, and travel expenses will be covered. Earn up to $300 plus travel expenses. For more information, call 410-550-2588 or 410-550-5295 or email johnshopkins.lab@gmail.com. Collect calls are accepted. Principal Investigator: Una D. McCann, MD (IRB Number: NA_0073552)

ANOREXIA

Anorexia Nervosa
Johns Hopkins researchers are conducting a placebo-controlled trial to examine the effectiveness of a research medication in the treatment of adults with anorexia nervosa. Participants will be offered 16 weeks of medication (active or inactive) and weekly outpatient medical monitoring by a psychiatrist. The treatment will be provided at no cost. To participate, you must have anorexia nervosa, be 18-55 years old, be medically stable for outpatient treatment, complete assessments (interviews, questionnaires and medical evaluations) at intervals throughout the 16-week study and at 1- and 2-month follow-ups. Information gathered will remain confidential. Call (410) 955-3863 for more information (NA_00040741) Site Principal Investigator: Angela S. Guarda, M.D. Click here for flyer.

 AUTISM

VANILLA: A Multi-Center, Randomized, Double-Blind, 12-Week, Parallel Group, Placebo-Controlled Proof of Concept Study to Investigate the Efficacy and Safety of RO5285119 in Individuals with Autism Spectrum Disorders (ASD)
Kennedy Krieger Institute is looking for adult men, ages 18 to 45 years (inclusive), who have been diagnosed with Autism Spectrum Disorder (ASD).  This research study is being conducted by centers across the country investigate the efficacy and safety of a study drug called RO5285119 on social behavior and communication in individuals with ASD.  The research study involves taking either study drug or placebo and visits which will consist of behavior and emotional assessments and physical examinations. You may or may not receive direct medical benefits for participating in this research study. The research study will last about 18 weeks.  You will not be paid for this research study. For more information about this research study, please contact the Study Coordinator at (443) 923-3850 or by email at ResearchTrials@kennedykrieger.org Study Sponsor: Roche Kennedy Krieger Institute PI: Dr. Robert Findling Protocol #: NA_00086294 www.clinicaltrials.gov (#NCT01793441)

Motor Skill Learning in Autism: Assessment and Treatment of Altered Patterns of Learning - Ages 8-12
Dr. Stewart H. Mostofsky of the Kennedy Krieger Institute and Johns Hopkins School of Medicine is recruiting children with and without high-functioning autism between 8 and 12 years of age to participate in a study of attention, learning, memory, and motor skills. The study involves paper and pencil tasks, computer activities, and MRI scan of the brain. None of the tests are harmful or painful and are done free of charge. There are no direct medical benefits for participating in the study. The duration of the study is two to three days. Participants will receive a $100 check and a picture of their brain. Parents will receive a report summarizing the IQ testing administered to their child. For more information about this study, please contact Alyssa Tiedemann at (443) 923-9263 or LNIR@kennedykrieger.org (IRB Protocol # NA_00027073)

BULIMIA

Bulimia Nervosa
We are seeking female subjects (18 yrs old and older) with bulimia nervosa to participate in an outpatient research study. This study requires you to drink a chocolate shake, place your hand in an ice bath, and have your blood drawn. Participation involves an initial 30 min screening and two (approx. 3.5 hour each) morning sessions. You will be paid up to $120 for your participation. For more information call Dr. Margaret Seide (410)-955-8003 or email at mseide2@jhmi.edu Principal Investigator: Angela S. Guarda, M.D. Click here for flyer (NA_00032632)

EATING DISORDERS

Brain and Appetite Research Study: Neurobehavioral Influences on Body Weight in Adolescents
Johns Hopkins Hospital is conducting a research study in adolescents (14-18 y old) and their biological mothers. The study involves three visits for 3-3.5 hours each. Study includes fMRI scan (adolescent only), body composition measurements (height, weight, waist), questionnaires, computer tasks, liquid and buffet meals, and saliva collection. Compensation is up to $245, plus $10 travel costs for each visit. Adolescent candidates must be 14-18 y old, must not be pregnant, claustrophobic or have any metal implants. All candidates must speak English fluently and not have any major medical or psychiatric conditions. Candidates must not have any food or nut allergies or be on any medications affecting weight or appetite. Contact information: Call 410-955-5099 or email lbenson9@jhmi.edu. PI: Susan Carnell, PhD (IRB #: NA_00092328) DOWNLOAD FLYER

Bulimia Nervosa
We are seeking female subjects (18 yrs old and older) with bulimia nervosa to participate in an outpatient research study. This study requires you to drink a chocolate shake, place your hand in an ice bath, and have your blood drawn. Participation involves an initial 30 min screening and two (approx. 3.5 hour each) morning sessions. You will be paid up to $120 for your participation. For more information call Dr. Margaret Seide (410)-955-8003 or email at mseide2@jhmi.edu Principal Investigator: Angela S. Guarda, M.D. Click here for flyer (NA_00032632)

Anorexia Nervosa
Johns Hopkins researchers are conducting a placebo-controlled trial to examine the effectiveness of a research medication in the treatment of adults with anorexia nervosa. Participants will be offered 16 weeks of medication (active or inactive) and weekly outpatient medical monitoring by a psychiatrist. The treatment will be provided at no cost. To participate, you must have anorexia nervosa, be 18-55 years old, be medically stable for outpatient treatment, complete assessments (interviews, questionnaires and medical evaluations) at intervals throughout the 16-week study and at 1- and 2-month follow-ups. Information gathered will remain confidential. Call (410) 955-3863 for more information (NA_00040741) Site Principal Investigator: Angela S. Guarda, M.D. Click here for flyer.

MEMORY DISORDERS

Molecular Brain Imaging of Nicotinic Cholinergic Receptors in Normal Aging, Mild Cognitive Impairment and Alzheimer’s Disease
Our study uses a new molecular imaging method designed to visualize distribution of certain nicotinic acetylcholine receptors in the brain. Past research suggests that these nicotinic acetylcholine receptors are reduced in number in the human brain over normal aging and in patients with Mild Cognitive Impairment (MCI) and Alzheimer’s Disease. We aim to visualize the distribution of these receptors in the brain by using a novel radiotracer that targets the α4β2 nicotinic acetylcholine receptor by using positron emission tomography (PET).  Use of this new, sensitive medical imaging technology may help us to better understand how deficits in cognition may be linked to loss of these receptors over aging and in disease--and inform development of new therapies to target these receptors to possibly improve symptoms.  We are recruiting patients with MCI and Alzheimer's Disease as well as healthy controls between the ages 35-90 years. This brain imaging study consists of a 90 minute PET scan, a MRI scan, and blood work across 2 to 3 study visits.  Volunteers are compensated for their time. For more information and to undergo a phone screening to determine eligibility please contact: Dr. Jennifer Coughlin, Co-Investigator: jcoughl2@jhmi.edu; 443-287-4701. PI: Martin G. Pomper, M.D., Ph.D. IRB # NA_00076249

Sports-Related Brain Injury in NFL Players: Tau Protein
Abnormal deposition of tau protein can contribute to damaging effects on neurons in the brain and may ultimately play a role in memory decline characteristic of some types of dementia.  Recent studies of autopsy brain tissue suggest that increased deposits of tau protein may also occur in the brains of athletes suffering repetitive hits to the head, as in professional American football.  There have also been published reports suggesting that former NFL players show more changes in cognition and mood than would be expected over a normal aging process.  Building on these limited findings, we are studying whether there is a link between cognitive performance, psychiatric disease, and deposition of tau in the brains of active and recently retired NFL players.  Our study uses positron emission tomography (PET) imaging of the brain and a particular radiotracer that allows very sensitive, precise, and safe medical imaging of deposits of tau in the brains of living humans.  We are recruiting active and recently retired NFL players as well as non-professional athletes as healthy controls. The study consists of a 90 minute PET scan, an MRI scan, memory testing, psychiatric interview, and bloodwork across two to three study visits. There is also an optional lumbar puncture. Volunteers are compensated for their time. For more information and to undergo a phone screening to determine eligibility please contact: Dr. Jennifer Coughlin, Co-Investigator: jcoughl2@jhmi.edu; 443-287-4701. PI: Martin G. Pomper, M.D., Ph.D. IRB # 00046416

Dietary Study for Older Adults with Mild Memory Impairment
Older adults with mild memory impairment (especially those with early Alzheimer’s disease) are needed for a research study of dietary treatments. This is 12-week clinical trial of a high-fat, low-carbohydrate diet vs. a low-fat diet high in fruits, vegetables and grains. Both diets are considered safe for most physically healthy older adults. All education, support, and vitamin supplements provided free of charge. You can stay on your existing medications. Your physician will be asked to agree to your participation. Johns Hopkins Medicine IRB # 00066092, Jason Brandt, Ph.D., Principal Investigator. For more information, please call Emilee Naylor at 410-955-1647. Download flyer.

MIND at Home Studies
Maximizing Independence (MIND) at Home is a comprehensive, home-based care coordination program designed to systematically assess and address the unmet needs of people with memory problems living at home and those of their family caregiver. The MIND at Home program provides education and links people in need of care to appropriate resources and services. Two MIND at Home studies—one funded by the Centers for Medicare & Medicaid Services and one funded by the National Institute on Aging—are now enrolling research volunteers. Goals of these studies are to find out if providing help in obtaining appropriate care for older adults with memory problems will help them remain at home longer and improve their quality of life. All study participants will receive an in-home needs assessment and a free written report with recommendations for care. Some participants will receive care coordination services for up to 18 months. If you or someone you know has a memory disorder and lives at home in the Baltimore region with no plans to move in the next 6 months, they may be eligible to join a MIND at Home study. To learn more about these two studies, please call us at 410-550-6744 or email us at mindathome@jhmi.edu. Principal Investigator: Quincy Samus, PhD (IRB Protocol Numbers:  IRB00054802, IRB00041744). MIND Study Flyer | CMS Mind Study Flyer

Alzheimer’s Disease/Brain Imaging Study
We are seeking participants for a brain imaging clinical research study. To join, you must be between 50-80 years of age, have a diagnosis of Alzheimer’s Disease, have a study partner who is willing and able to attend study visits and answer questions about you, and meet other study requirements that relate to your health. We will evaluate investigational brain imaging agents called radiotracers used for PET (Positron Emission Tomography) Scan imaging of the brain. We want to learn if one of these radiotracers might help test new medicines and gain a better understanding of Alzheimer’s Disease. If you are eligible, you will be compensated for your time and participation in the study. To find out more about this opportunity, please contact us at 410-955-0210.  Principal Investigator: Dean F. Wong, MD, PhD. (IRB Number _IRB00035115)

Mild Cognitive Impairment Study
Are you more forgetful lately? Do you have trouble with the names of people you’ve met recently? Do you get lost in new places? Do you have a greater tendency to misplace things? Do other people notice that you are forgetful? If you are age 55 or over, having memory problems, not taking antidepressant medication and in good health, you may be eligible to participate in a research study. Qualified people will participate at no cost to them and will be compensated for their time and transportation. For more information about the research study, please call us at 410-550-4192 or email us at BrainImagingStudy@lists.johnshopkins.edu. (Principal Investigator: Gwenn Smith, PhD, IRB Protocol No: NA_00026190) Download flyer.

Depression in Alzheimer’s Disease Study
People with Alzheimer’s disease can feel depressed. This condition is treatable with medication. Symptoms of depression can be loss of interest, feelings of hopelessness, persistent aches and pains, feeling sad, anxious or empty, loss of appetite, irritability, restlessness, insomnia or even excessive sleeping. We are conducting a research study to examine this and to see if a drug called venlafaxine may help. If you or someone you know is diagnosed with Alzheimer’s disease and experiencing feelings of depression, they may be eligible to participate in this study. If you are interested in learning more about this study please call Jane Pollutra 410-550-4258. Paul Rosenberg, M.D. Principal Investigator (JHU IRB Application #: NA_00066043)

Preliminary Study of Carvedilol for the Treatment of Alzheimer’s Disease
This study is being done to see if the anti-hypertensive drug carvedilol can improve thinking and memory in people with Alzheimer’s disease. Carvedilol is approved by the Food and Drug Administration for the treatment of hypertension (high blood pressure) and ventricular dysfunction. substances, which control the muscles in the heart. In an observational study of people with Alzheimer’s disease, there was some indication that people who took beta-blockers had a slower rate of decline in their thinking and memory. In studies using mice, daily doses of carvedilol decreased some of the toxic chemicals in the brain that are believed to cause Alzheimer’s disease. These initial observations suggest that carvedilol, by having a beneficial effect on vascular conditions in the brain, may decrease certain toxins in the brain. If you are interested in learning more about this study please call Jane Pollutra 410-550-4258. Paul Rosenberg, M.D. , Principal Investigator (JHU IRB Application #.: NA_00035546)

Oral Glucose Tolerance Test for Alzheimer’s Disease Biomarker Development
The purpose of this research is to find if there is a relationship between a chemical in the blood, which may be related to memory problems, and the body’s hormonal response from the pancreas, gut, and fat tissue after an oral glucose tolerance test. People with and without memory problems may join this study. The study involves a memory screening test and an oral glucose tolerance test. The results of these tests will help us with our research study related to memory, aging, and hormones. If you are interested in learning more about this study please call Jane Pollutra 410-550-4258. Esther Oh, M.D., Principal Investigator (JHU IRB Application No.: NA_00014837)

Memory & Aging Study
The Johns Hopkins Memory Center is currently conducting a study of the differences between normal aging, mild memory problems, and the onset of memory disorders like Alzheimer’s Disease. If you choose to participate in the Memory and Aging Study, you and a study partner will be invited to our clinic for a 2-3 hour assessment including memory testing, physical exam, and blood samples. We will ask you and your study partner questions about your daily functioning. You will return to our clinic once a year for an annual physical exam and memory testing. People, 60 years old or older, with or without memory problems, can participate in this study. If you are interested in learning more about this study please call Joanne Gamble at 410-550-9021. Constantine Lyketsos, MD, MPH,, Principal Investigator (JHU IRB Application No: NA_00045104)

Levetiracetum and Memory Function - Clinical Trial
A research study is being conducted at Johns Hopkins University to evaluate the daily use of an FDA approved medication in improving memory. For this study we are looking for older adults (50 to 85 years) who are interested in participating in memory research. Participation includes four visits to the Johns Hopkins Hospital where you may undergo memory testing, MRI scans, and be asked to take the study medication twice a day for a maximum of two weeks. The study may provide transportation to and from the hospital if needed, and participants will receive a total of $225 dollars at the end of the four study visits. If you are between the ages of 50 and 85, are able to have an MRI, and believe you are experiencing memory loss (or have been diagnosed with mild cognitive impairment), you may qualify for this study! To learn more, please contact the study coordinator, Caroline Speck, at 410-955-5057 or cspeck1@jhmi.edu Principal Investigator: Gregory Krauss, M.D. (Protocol Number: NA_00030573). Co-investigator: Arnold Bakker, Ph.D.

MOOD DISORDERS

A Research Study to determine whether an investigational drug called vilazodone is safe and effective to treat symptoms of major depressive disorder in children and adolescents.
This is a research study that is being conducted by Dr. Robert Findling at Kennedy Krieger Institute to determine whether vilazodone, an SSRI antidepressant for the treatment of major depressive disorder (MDD), is safe and effective for children and adolescents (ages 7 to 17 years). Eligible children and adolescents, with symptoms of MDD, will visit the Kennedy Krieger Institute for nine outpatient visits over a 10-week period; each outpatient visit will last about 3 hours. Participants will receive psychological, behavioral, and medical testing, including behavioral assessments, physical examinations, blood draws, vital signs, ECGs, urine drug screen, and pregnancy testing for females. There will be a reimbursement of $50.00 for each outpatient visit to compensate individuals for time and travel during participation in the research study. For more information about this research study, please contact Rebekah Teetsel at (443) 923-2637 or by email at Teetsel@kennedykrieger.org Research study Sponsor: Forest Research Institute, Inc. PI: Robert Findling, M.D., M.B.A. Johns Hopkins Medicine-IRB No. – IRB00054798

A Phase 3, Multicenter, Four-Week, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Efficacy And Safety Trial Of Flexible Doses Of Oral Ziprasidone In Children And Adolescents With Bipolar I Disorder (Current Or Most Recent Episode Manic)
This research study is being conducted by centers across the United States to help determine if ziprasidone is a safe and effective treatment for symptoms associated with bipolar I disorder (with a current or most recent episode being manic). Kennedy Krieger Institute is looking for children with bipolar I disorder (with a current or most recent episode being manic), ages 10 through 17 years, to participate in this research study. The research study involves up to seven visits to Kennedy Krieger Institute over seven weeks, each lasting about four hours. There are no direct medical benefits for participating in this research study. For each completed visit, participants will receive reimbursement of $45.50 for their time and travel expenses.   Please ask a study team member for spe cifics. All testing is done free of charge. For more information about this research study, please contact the Study Coordinator at (443) 923-3850 or by email at ResearchTrials@kennedykrieger.org Research study Sponsor: Pfizer, Inc. PI: Robert Findling, M.D., M.B.A. IRB No. – NA_00093875 www.clinicaltrials.gov (NCT02075047)

SPRITES: SERTRALINE PEDIATRIC REGISTRY FOR THE EVALUATION OF SAFETY - A Non-interventional, Longitudinal, Cohort Study to Evaluate the Effects of Long-term Sertraline Treatment in Children and Adolescents
Kennedy Krieger Institute is looking for children, ages 6 through 16 years (inclusive), who have been prescribed sertraline within the last 45 days, or have initiated psychosocial rather than pharmacological treatment within the last 45 days. This research study is being conducted by centers across the country to add meaningful information on the safety of long-term sertraline use in pediatric subjects.  The research study involves visits which will consist of cognition, emotional and physical development, and pubertal maturation assessments. There are no direct medical benefits for participating in this research study. The research study will require a screening visit that could last up to 2 hours as well as visits at 12 weeks, 6 months, and every 6 months thereafter for 3 years (each lasting approximately 30 minutes).  For each completed visit, you will be reimbursed up to $25.00 for your expenses related to your child’s participation to cover your parking, gas, and time. [OR] Your child will receive a $10.00 iTunes® card (or equivalent) to compensate them for their time. For more information about this study, please contact the Study Coordinator at (443) 923-7619 or by email at ResearchTrials@kennedykrieger.org Study Sponsor: Pfizer PI: Dr. Robert Findling Protocol #: NA_00083788 www.clinicaltrials.gov (#NCT01302080)

A research study to investigate the safety and effectiveness of lurasidone in children and adolescents with bipolar depression
This research study is being conducted by Kennedy Krieger Institute and other centers across the United States to evaluate the safety and effectiveness of Latuda® (lurasidone), compared with placebo, in male and female pediatric and adolescent subjects ages 10 to 17 years, with bipolar depression. The research study involves up to 9 visits to Kennedy Krieger Institute over 10 weeks, each lasting about 2 to 4 hours. For each completed visit, participants will receive a reimbursement of $50.00 for their time and travel expenses.  Please ask a study team member for specifics.  All testing is done free of charge. For more information about this research study, please contact the Study Coordinator Name at (443) 923-3850 or by email at ResearchTrials@kennedykrieger.org PI: Robert Findling, M.D., M.B.A. Johns Hopkins Medicine-IRB No. – IRB00031760 www.clinicaltrials.gov (NCT02046369) Sponsor: Sunovion

Psychotherapy for Adolescents
We are conducting a research study at Johns Hopkins that evaluates the effectiveness of a specific psychotherapy for adolescents, between the ages of 12 and 17, who have chronic anger and irritability, disproportionate emotional reactions (rages, outbursts), and may have other associated symptoms (problems with sleep or concentration, restlessness, talkativeness). Because of the mood symptoms, these youth may have difficulties with relationships.  The goal of the study is to improve mood and relationships through interpersonal psychotherapy.  As part of the study, teens will receive a free comprehensive evaluation and may earn up to $135 in gift cards.   Parents may earn up to $135 for participation.  For more information please contact the Principal Investigator, Leslie Miller, M.D. at (410) 550-9014 or email roar@jhmi.edu.   (IRB protocol #NA_00083893)

Mood Disorders Research Study
Do you have a history of major depression or bipolar disorder? Are you pregnant or planning on becoming pregnant? If so, you may qualify for a research study to assess how mood disorders affect pregnant women. Pregnant women will be seen and evaluated during pregnancy as well as 1-2 weeks, 6 weeks, 3 months and 6 months postpartum. Volunteers will be compensated for their participation. For more information, please call (410) 502-2586 or e-mail smeilma1@jhmi.edu. Principal Investigator: Jennifer Payne, M.D.  (Protocol #: IRB00027369)

First Episode Psychosis
Longitudinal Characterization of Molecular Biomarker Changes Over the Early Course of Psychotic Disease
Researchers are seeking individuals diagnosed with a psychotic disorder to participate in a research study being done to study the cells of patients with psychotic disorders. Your participation may help improve the treatment of psychotic disorders for patients like you. This study is a longitudinal study over the course of three years (only a few visits required per year): you can earn up to $1740. To be eligible for this study, you must be between 13-35 years of age with a psychotic disorder diagnosis – this may include schizophrenia, bipolar disorder, and mood disorders. Qualified participants have the option of undergoing: blood draw, skin biopsy, nasal biopsy, lumbar puncture, and two sessions of brain scanning with MRI technology. To learn more, please call Candice at 443-287-4986 or email at cford15@jhmi.edu. (NA_00082086, Principal Investigator: Akira Sawa, MD, PhD)

Translational Cellular Models for Mood Disorders 
If you have been diagnosed with Bipolar Disorder: Type I, you may qualify to participate in a research study at the Johns Hopkins Mood Disorders Center. This study would potentially involve an interview with our study physician, a blood draw, a small (2mm) skin sample, and a nasal sample. Compensation of up to $275 is available for participation. If you are interested in participating, please contact our research staff at 443-287-2981 or email moods@jhu.edu. Principal Investigator: Fernando Goes, M.D. (IRB Protocol #NA_00044928)

Clinical Trial for TMS with Mood Stabilizers in Bipolar Depression
If you are between the ages of 22-68, currently suffering from Bipolar depression, and are currently taking a mood stabilizer you may be eligible to participate in a research study on deep Transcranial Magnetic Stimulation (dTMS). This study is being conducted to evaluate the safety and effectiveness of the H-Coil Transcranial Magnetic Stimulation (TMS) in treating bipolar depression. Participation involves 25 visits over 8 weeks. There are up to three weeks for screening visits to determine eligibility. During this time participants will also need to be gradually taken off of psychiatric medications except for a mood stabilizer. Once eligible, there are 8 weeks of the study procedure including 2 follow-up visits. Participants will have a 50% chance of receiving real TMS or sham TMS once a day, 5 days per week for 4 consecutive weeks, then 3 times during week 5, and once during week 6.  Participant safety will be monitored, and each participant will be asked questions pertaining to their mood and anxiety. There will be compensation for participating in this study. For more information please call 410-614-1732. The principal investigator is Dr. Irving Reti. (IRB Protocol NA_00045624).

Pharmacogenomics of Mood Stabilizer Response in Bipolar Disorder (PGBD)
We are looking for adults ages 18 and older who have bipolar disorder and are not pregnant.  Our purpose is to stabilize participants with bipolar disorder on lithium alone in order to learn which genes are associated with a good response to medication. The study lasts up to 2.5 years, and involves clinician assessments, questionnaires, routine lab work, and taking a blood sample for DNA.  You will be paid for participating in this research.  You will receive ongoing care during the course of the study from our study psychiatrist, Dr. Francis Mondimore, at the Johns Hopkins Bayview Mood Disorders Clinic.  Or, you can continue to receive your clinical care from your current psychiatrist in close consultation with Dr. Mondimore while you participate in the study.  For more information, please call 410-550-1652 or email moods@jhu.edu.  Principal Investigator: Peter Zandi, PhD, MPH, MHS (IRB Protocol NA_00043300). Click here for PDF brochure.

Mood Disorders and Pregnancy Study
The Johns Hopkins Women's Mood Disorders Center is currently seeking women who have a history of depression or bipolar disorder to participate in a naturalistic study that would follow them during pregnancy and the postpartum period.  Participants may enter during any trimester and would have visits during each trimester and 1 week, 1 month, and 3 months postpartum.  Volunteers will be compensated for their participation.  For more information, please call 410-502-2586 or email moodtrials@jhmi.eduJennifer Payne, MD is the principal investigator.  (IRB Protocol #NA_00008149)

Geriatric Depression Study
Are you over 60 and feeling depressed? Symptoms of depression in older adults are common yet often go undetected. Symptoms could include feelings of sadness or hopelessness, loss of energy, inability to enjoy pleasurable activities, changes in appetite or sleeping patterns, or poor concentration/memory. If you are feeling depressed, not taking antidepressant medication and in good physical health you may be eligible to participate in a research study involving treatment. Qualified people will participate at no cost to them and will be compensated for their time and transportation. For more information about the research study, please call us at 410-550-4192 or email us at BrainImagingStudy@lists.johnshopkins.edu . Download PDF flyer. Principal Investigator: Gwenn Smith, PhD (IRB Protocol No: NA_00021615)

NEURODEVELOPMENTAL DISABILITIES

A Randomized, Placebo-Controlled Study To Investigate The Efficacy And Safety Of Circadin® To Alleviate Sleep Disturbances In Children With Neurodevelopmental Disabilities
This research study is being conducted by centers across the United States to help determine if Circadin is a safe and effective treatment to alleviate sleep disturbances in children with neurodevelopmental disabilities.  Kennedy Krieger Institute is looking for children ages 2 through 17.5 years, to participate in this study. The study involves up to 10 visits to Kennedy Krieger Institute over 112 weeks.  There are no direct medical benefits for participating in this study.  All testing is done at no cost to the participant and parking is free. For more information about this study, please contact the Study Coordinator at (443) 923-3850 or by email at ResearchTrials@kennedykrieger.org PI: Robert Findling, M.D., M.B.A. Protocol #: NA_00089733 www.clinicaltrials.gov (NCT01906866) The Sponsor for this study is Neurim Pharmaceuticals

OBESITY

Brain and Appetite Research Study: Neurobehavioral Influences on Body Weight in Adolescents
Johns Hopkins Hospital is conducting a research study in adolescents (14-18 y old) and their biological mothers. The study involves three visits for 3-3.5 hours each. Study includes fMRI scan (adolescent only), body composition measurements (height, weight, waist), questionnaires, computer tasks, liquid and buffet meals, and saliva collection. Compensation is up to $245, plus $10 travel costs for each visit. Adolescent candidates must be 14-18 y old, must not be pregnant, claustrophobic or have any metal implants. All candidates must speak English fluently and not have any major medical or psychiatric conditions. Candidates must not have any food or nut allergies or be on any medications affecting weight or appetite. Contact information: Call 410-955-5099 or email lbenson9@jhmi.edu. PI: Susan Carnell, PhD (IRB #: NA_00092328) DOWNLOAD FLYER

Eating and Impulsivity Study- Children aged 8-14 years
We are recruiting children between the ages of 8 and 14 years to participate in a study examining impulsivity ( whether kids act before they think), eating behavior and weight. The study involves a single visit, lasting  from 4 to 6 hours. The visit includes a diagnostic interview, psychological testing , weight and height measurement.  Testing is free. Reimbursement for time and inconvenience is $100; parking voucher provided.  For more information please contact Principal Investigator Shauna P. Reinblatt, M.D. at 410-550-9947. Please click here to download a PDF flyer (IRB Protocol #  NA_00020561).

OBSESSIVE-COMPULSIVE DISORDERS

Genetics of Obsessive-Compulsive Disorder (Adults and Children)
We are investigating genetic factors which may increase the susceptibility to OCD. Recent advances in molecular biology and statistical genetics make it possible to identify and describe specific genes that may cause complex diseases such as OCD. Individuals with OCD are invited to participate in the study. Participants are given a confidential interview about their medical history and will be asked to provide a small sample of blood. Participants do NOT need to travel. Confidentiality of all information is assured. Families may be referred by a clinician or they may contact us directly. Gerald Nestadt, M.D., M.P.H. is the principal investigator. Call 410-614-4942. (Collect calls accepted) or email JACK SAMUELS jacks@jhmi.edu (IRB Protocol # NA_00039786)

PAIN

Investigational Pain Treatment Study for Volunteers Prescribed Buprenorphine/Suboxone®
Healthy volunteers prescribed buprenorphine/Suboxone at 12-16 milligrams per day are needed for an investigational pain treatment research study. Volunteers must not be using any other drugs, must have stable chronic pain, and be wiling to stay overnight on a research unit. Volunteers are compensated up to $675. Please call 410-550-9494.  Principal Investigator: Andrew Tompkins, M.D. (NA_00093537) Download Flyer

MRI Outcomes of Mindfulness Meditation for Migraine
Do You Have Migraine Headaches? Researchers at the University of Maryland School of Dentistry and Johns Hopkins School of Medicine are looking for volunteers to participate in a research study examining the effects of two different non-drug techniques for reducing headaches. The techniques focus on learning different stress management strategies and one group will learn meditation. To participate, you must: be between 18 and 65 years of age, experience 4 to 14 headaches per month, have had migraines for at least 1 year, and not be using opioid (“narcotic”) pain medication. To see if you are eligible, you must complete: two screening visits that include evaluation and questionnaires, sensory testing procedures, one or more MRI’s of your brain, and daily migraine diaries completed online. If you are eligible, the study involves: assignment to one of two stress management groups. Both groups use non-drug techniques and one group includes mindfulness meditation. Each group includes 12-13 sessions that will occur over a 4 month period. All examinations, parking, & tests are provided at no cost. Compensation up to $900.00, for completing ALL study visits. Please call today at 410.550.9056. Principal Investigators: Jennifer Haythornthwaite, Ph.D. and Dr. David Seminowicz IRB #: NA_00091884. DOWNLOAD FLYER

Predicting Outcomes Following Total Knee Replacement
Researchers at the Johns Hopkins School of Medicine and the Department of Orthopedic Surgery are looking for volunteers to participate in a research study examining pain and sleep following knee replacement surgery. The study involves measuring your responses to various sensations, including hot and cold, measuring other aspects of your quality of life, and your comfort walking. You may be eligible if you: are at least 45 years old, have osteoarthritis in your knee(s), and will be undergoing knee replacement surgery. If you are eligible, the study involves: 1 visit to Johns Hopkins Bayview before your surgery, and up to 3 visits to Johns Hopkins Bayview after your surgery. All study procedures and parking will be provided at no cost to you. Compensation up to $910.00 for full (approximately 13 months) participation. Please call today at 410.550.4225 or email knee@jhu.edu. Principal Investigator: Jennifer Haythornthwaite, Ph.D. IRB #: NA_00015733. DOWNLOAD FLYER

Temporomandibular Joint Disorders (TMJD), Pain, and Sleep
Do you have jaw muscle pain?  Researchers at Johns Hopkins are looking for female volunteers with Temporomandibular Joint Disorders (TMJD) pain to participate in a research study funded by the National Institutes of Health to investigate how sleep and unhelpful thoughts about TMJD impact pain sensitivity and symptoms related to TMJD. You may be eligible if you: Are a female between 18-60 years of age, have had jaw muscle pain for 3 months or more, have sleep difficulties. Study Includes: A dental evaluation for TMJD, completing interviews and questionnaires, 2 ambulatory sleep studies that you can do in your own home, completing sensory testing procedures, 8 total study visits over 3 months and 1 telephone follow-up 3 months after completing the study. Earn up to $650.00. Please contact: Mary Redding at 410-550-8099. Principal Investigator: Jennifer Haythornthwaite, M.D. (Study #: NA_00070364) Download flyer

PARKINSON'S DISEASE

Parkinson’s Disease Clinical Trial For People with Mild-Cognitive Impairments
Investigators at the Johns Hopkins Hospital seek volunteers with Parkinson’s disease, over 45-80 years old, for participation in a multi-site research study funded by EMD Serono, Inc. If you have difficulty with your memory, you may qualify for this study. Please call Melissa Gerstenhaber, R.N. at (410) 614-1242. Principal Investigator: Gregory Pontone, M.D.      (IRB# NA_00040875). Click here for PDF flyer.

Database for Future Research Studies
Investigators seek volunteers with Parkinson's disease and volunteers without neurological disease over age 21 who agree to be contacted for future research studies. This does not obligate you to participate in any study you many be contacted about. Please call Melissa Gerstenhaber, R.N. at (410) 614-1242. Gregory Pontone, M.D. is the principal investigator. (IRB Protocol # 98-05-08-06). Click here for a PDF flyer.

PSYCHOSIS

First Episode Psychosis
Longitudinal Characterization of Molecular Biomarker Changes Over the Early Course of Psychotic Disease
Researchers are seeking individuals diagnosed with a psychotic disorder to participate in a research study being done to study the cells of patients with psychotic disorders. Your participation may help improve the treatment of psychotic disorders for patients like you. This study is a longitudinal study over the course of three years (only a few visits required per year): you can earn up to $1740. To be eligible for this study, you must be between 13-35 years of age with a psychotic disorder diagnosis – this may include schizophrenia, bipolar disorder, and mood disorders. Qualified participants have the option of undergoing: blood draw, skin biopsy, nasal biopsy, lumbar puncture, and two sessions of brain scanning with MRI technology. To learn more, please call Candice at 443-287-4986 or email at cford15@jhmi.edu. (NA_00082086, Principal Investigator: Akira Sawa, MD, PhD)

SCHIZOPHRENIA

An Adaptive, Phase IIb/III, Double-Blind, Randomized, Placebo- Controlled, Multi-Center Study of the Safety and Efficacy of NaBen® (Sodium Benzoate), a D-Amino Acid Oxidase Inhibitor, as an Add-on Treatment for Schizophrenia in Adolescents
This research study is being conducted by centers across the United States to evaluate the safety and effectiveness of NaBen® (sodium benzoate), compared with placebo, in male and female adolescents, ages 12 to 16 years, with schizophrenia. The research study involves up to seven visits to Kennedy Krieger Institute over ten weeks, each lasting about 2-3 hours. There are no direct medical benefits for participating in this research study. For each completed visit, participants will receive reimbursement of $65.00 for their time and travel expenses.   Please ask a study team member for specifics. All testing is done free of charge. For more information about this research study, please contact the Study Coordinator at (443) 923-3850 or by email at ResearchTrials@kennedykrieger.org Research study Sponsor: SyneuRx International Corp. PI: Robert Findling, M.D., M.B.A.IRB No. – IRB00030540 www.clinicaltrials.gov (NCT01908192)

A Research Study to determine whether an investigational drug called brexpiprazole is safe and effective to treat symptoms of Schizophrenia and related psychiatric disorders
This research study is being conducted by Kennedy Krieger Institute/centers across the United States to determine whether brexpiprazole is safe and effective in adolescents with schizophrenia or a related psychiatric disorder. If eligible, the participant will visit the Kennedy Krieger Institute up to 9 times over a period of 102 days. Each visit will take between 30 minutes and 2 hours and will include psychological and behavioral testing, medical history, physical examination, blood draws, HIV testing, vital sign, ECG, urine drug screen, and pregnancy testing for females. For each completed visit, participants will receive a reimbursement of $75.00 for their time and travel expenses. Please ask a study team member for specifics. All testing is done free of charge. For more information about this research study, please contact Becky Hinton at (443) 923- 9326 or by email at hinton@Kennedy KriegerResearch study Sponsor: Otsuka Pharamaceuticals PI: Robert Findling, M.D., M.B.A.Johns Hopkins Medicine-IRB No. – IRB00039001

A 6-WEEK RANDOMIZED, PARALLEL, DOUBLEBLIND, PLACEBO-CONTROLLED, FIXED-DOSE, MULTICENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF LURASIDONE IN ADOLESCENT SUBJECTS WITH SCHIZOPHRENIA

This research study is being conducted by centers across the United States to help determine if lurasidone a safe and effective treatment for symptoms associated with acute schizophrenia. Kennedy Krieger Institute is looking for children with acute schizophrenia, ages 13 through 17 years, to participate in this research study. The research study involves up to 10 visits to Kennedy Krieger Institute over 10 weeks, each lasting 5-6 hours. There are no direct medical benefits for participating in this research study.  For each completed visit, participants will receive reimbursement for their time and travel expenses.  Please ask a study team member for specifics.  All testing is done free of charge. For more information about this research study, please contact the Study Coordinator at (443) 923-3850 or by email at ResearchTrials@kennedykrieger.org Research study Sponsor: Sunovion Pharmaceuticals, Inc. PI: Robert Findling, M.D., M.B.A. IRB No. – NA_00092723 www.clinicaltrials.gov (NCT01911429)

First Episode Psychosis
Longitudinal Characterization of Molecular Biomarker Changes Over the Early Course of Psychotic Disease
Researchers are seeking individuals diagnosed with a psychotic disorder to participate in a research study being done to study the cells of patients with psychotic disorders. Your participation may help improve the treatment of psychotic disorders for patients like you. This study is a longitudinal study over the course of three years (only a few visits required per year): you can earn up to $1740. To be eligible for this study, you must be between 13-35 years of age with a psychotic disorder diagnosis – this may include schizophrenia, bipolar disorder, and mood disorders. Qualified participants have the option of undergoing: blood draw, skin biopsy, nasal biopsy, lumbar puncture, and two sessions of brain scanning with MRI technology. To learn more, please call Candice at 443-287-4986 or email at cford15@jhmi.edu. (NA_00082086, Principal Investigator: Akira Sawa, MD, PhD)

Cell and MRI Study of Patients with Schizophrenia
Do you have Schizophrenia? Are you between 18-65 years of age? You may be the perfect candidate for our study! Researchers are seeking individuals diagnosed with Schizophrenia to participate in a research study being done to study the cells of patients with schizophrenia. The study takes place over the course of two weeks, during which you can earn a compensation of up to $500! Qualified participants will have the option of undergoing neuropsychological testing with a study team member, a blood draw, a nasal biopsy, and three sessions of brain scanning using MRI technology.To learn more, please call Cecilia Higgs, chiggs@jhmi.edu 443-287-2981. (Principal Investigator: Akira Sawa, M.D., Ph.D., (IRB # NA_00037204)

Using a Novel PET Ligand for Imaging Brains 
Earn up to $350 in only three visits! The purpose of our study is to validate the use of a new technique to image inflammation in brains of patients with recent onset Schizophrenia.  In particular, we aim to image inflammatory activation using Positron Emission Tomography (PET). We are recruiting patients with recent onset Schizophrenia (and in the first five years of the disease). To be eligible for the study, you must be over 18 years old. As a study participant, you will be asked to undergo preliminary tests including: a blood draw, a urine sample, a pregnancy test (if applicable), an EKG test (painless measurement of your heart’s electrical activity), neuropsychological testing and a physical exam. In addition, we will schedule 2 imaging visits, 1 MRI and 1 PET scan visit. Participants will receive compensation of up to $350, paid in segments after completion of each portion of the study. To learn more, please call Dr. Coughlin at 443-287-4701or email at jcoughl2@jhmi.edu. (NA_00023849, Principal Investigator: Martin Pomper, M.D., Ph.D)

SLEEP DISORDERS

Temporomandibular Joint Disorders (TMJD), Pain, and Sleep
Do you have jaw muscle pain?  Researchers at Johns Hopkins are looking for female volunteers with Temporomandibular Joint Disorders (TMJD) pain to participate in a research study funded by the National Institutes of Health to investigate how sleep and unhelpful thoughts about TMJD impact pain sensitivity and symptoms related to TMJD. You may be eligible if you: Are a female between 18-60 years of age, have had jaw muscle pain for 3 months or more, have sleep difficulties. Study Includes: A dental evaluation for TMJD, completing interviews and questionnaires, 2 ambulatory sleep studies that you can do in your own home, completing sensory testing procedures, 8 total study visits over 3 months and 1 telephone follow-up 3 months after completing the study. Earn up to $650.00. Please contact: Mary Redding at 410-550-8099. Principal Investigator: Jennifer Haythornthwaite, Ph.D. (Study #: NA_00070364) Download flyer

SUBSTANCE ABUSE / ADDICTIONS

Investigational Pain Treatment Study for Volunteers Prescribed Buprenorphine/Suboxone®
Healthy volunteers prescribed buprenorphine/Suboxone at 12-16 milligrams per day are needed for an investigational pain treatment research study. Volunteers must not be using any other drugs, must have stable chronic pain, and be wiling to stay overnight on a research unit. Volunteers are compensated up to $675. Please call 410-550-9494.  Principal Investigator: Andrew Tompkins, M.D. (NA_00093537) Download Flyer

Investigational Research on Heavy Drinking
Do you have a drinking problem? Researchers at the Johns Hopkins Bayview campus are conducting a research study testing a medication that may help people reduce their drinking. Participation requires 13 visits over about 26 weeks. Participation is confidential. Compensation will be provided for your time. Call 410-550-1916 for more information and to complete a 15-minute phone interview to determine whether you might be eligible. Principal Investigator:  Eric Strain, MD (Study Number: IRB00058551)

Effects of Oral Cocaine on Decision Making
Healthy men and women ages 18-45 who have used cocaine are needed to participate in a research study about effects of oral cocaine on decision making at the Johns Hopkins Bayview Medical Center. This is not a treatment study. This study requires one 3-4 hour screening visit & 3 sessions lasting about 4 hours each. Earn up to $250 for completing the entire study. For more information please call 410-550-1465. Principal Investigator: Matthew W. Johnson, Ph.D.. Application # NA_00074996 Download flyer

Do You Smoke?
A NIH-funded research project is being done to learn more about how nicotine and the medication Varenicline affect the brain and behavior. Varenicline is FDA-approved for smoking cessation treatment and marketed as Chantix, a drug used to help people quit smoking. We also want to learn more about the genetic and environmental risk factors for nicotine addiction. The study requires three visits, one of which includes staying on the research unit at Johns Hopkins Hospital for six nights. Compensation up to $695 will be provided for study completion. For more information, call  IPSAR at 410.502-5433 Principal Investigator:  Mary E. McCaul, PhD. (Protocol # NA_00031348)   Download Flyer

Nicotine Patch Research Study
This research study is being done to learn more about brain changes during active smoking and nicotine withdrawal. We will be studying the brain using noninvasive imaging in both smokers and non-smokers. Participants will complete 2 visits, one of which includes staying on a research unit for 3 nights. Compensation up to $600 will be provided for study completion. For more information, call 410.502-5433. Principal Investigator: Mary E. McCaul, PhD   Download Flyer
(RPN:  NA_00036996)

Help Cutting Down Caffeine
Have you tried unsuccessfully to quit or cut down caffeine use? Do you think you may be addicted to caffeine? If you are between the ages of 18 and 70 and are seeking help to quit or reduce caffeine, you may be eligible for caffeine treatment research at Johns Hopkins Bayview at no monetary cost to you. Principal Investigator: Roland Griffiths, Ph.D. Study Number NA_00051415 Download Flyer

Opioid users (heroin or prescription pain relievers) looking for withdrawal treatment
Are you 18-60 years old, currently addicted to heroin or prescription pain relievers and seeking treatment? Researchers at Johns Hopkins Bayview Medical Center are conducting an inpatient research study to test an investigational medication for opioid withdrawal.  Participation requires you to live on our Clinical Research Unit for up to 28 days. If you qualify, you will receive study-related care at no cost and you will be compensated. Compensation of up to $700. Call 410-550-0490 for phone screening. Principal Investigator:  Eric Strain, MD (Protocol # NA_00037871). Download Flyer

Attention cigarette smokers
The Smoking Clinic at The Johns Hopkins Bayview Medical Center is currently recruiting adult research volunteers who are interested in trying new cigarettes.  This research does not provide treatment and is not for people trying to quit smoking.  Research participation requires visits to the Johns Hopkins Bayview Medical Center 1 or 2 times each week.  Scheduling is flexible and you will be compensated for your time.   If you are interested call us at 410-550-5143 for details.  Again, the Smoking Clinic at the Johns Hopkins Bayview Medical Center is looking for daily cigarette smokers to participate in research studies.  Call us at 410-550-5143 for details.  All calls are confidential.  Download Flyer

Buprenorphine, Suboxone and Methadone Study
Volunteers between the ages of 18 and 55 who are prescribed buprenorphine or methadone are needed for a research study at Johns Hopkins Bayview Medical Center. Volunteers must not be using any other drugs. Participants also must be healthy, pain free, and willing to stay overnight on a research unit. Compensation is provided up to $375. Please call 410-550-9494 to see if you may qualify. Principal Investigator: Andrew Tompkins, M.D. (NA_00071459) Download flyer.

Marijuana Treatment Study
Marijuana users 18-55 years old are needed to take part in a research study of marijuana use and sleep at Johns Hopkins. Study volunteers will complete a 12-week program designed to help stop use of marijuana.  Study includes investigational medication and advanced assessments of sleep. Call (410) 550-2695 for details. Principal Investigator: Ryan Vandrey, Ph.D. Study Number: NA_00068969

Smokers Wanting to Quit
Johns Hopkins University School of Medicine is seeking cigarette smokers who would like to quit smoking for participation in a scientific research study. The study involves free counseling and treatment provided in a comfortable, supportive setting. Transdermal nicotine patches, an FDA approved smoking cessation treatment, may be provided in the study. Cognitive behavior therapy and ongoing interpersonal support will be provided in order to help volunteers quit smoking. Questionnaires, interviews, MRI scans, and biological measures of smoking will be used to assess the treatment’s effects on mood, and smoking. Volunteers must be right handed, must be between the ages of 21 and 65, and must live within travel distance of the Hopkins Bayview campus in Baltimore. If you would like to discuss the possibility of volunteering, please call 410–550–1972 and ask for Albert, the study’s research coordinator or go to www.smoking-insight.org­. Confidentiality will be maintained for all applicants and participants. Principal Investigator: Matthew W. Johnson, Ph.D., (Protocol: NA_00016166) Download Flyer

Methamphetamine Users
Methamphetamine users are needed for a medical research study. Volunteers should be between the ages of 18-45, in good general health and taking no regular medications. Testing will take place at the Johns Hopkins Bayview Medical Center and the Johns Hopkins Hospital in Baltimore, MD. Volunteers will be paid for completion of all study procedures. Travel expenses will be covered. Please call 410-550-2588 or 410-550-5295 or email johnshopkins.lab@gmail.com for more information. Principal Investigator: Una D. McCann (IRB Number: NA_00031313)

Traumatic Brain Injury

Sports-Related Brain Injury in NFL Players: Tau Protein
Abnormal deposition of tau protein can contribute to damaging effects on neurons in the brain and may ultimately play a role in memory decline characteristic of some types of dementia.  Recent studies of autopsy brain tissue suggest that increased deposits of tau protein may also occur in the brains of athletes suffering repetitive hits to the head, as in professional American football.  There have also been published reports suggesting that former NFL players show more changes in cognition and mood than would be expected over a normal aging process.  Building on these limited findings, we are studying whether there is a link between cognitive performance, psychiatric disease, and deposition of tau in the brains of active and recently retired NFL players.  Our study uses positron emission tomography (PET) imaging of the brain and a particular radiotracer that allows very sensitive, precise, and safe medical imaging of deposits of tau in the brains of living humans.  We are recruiting active and recently retired NFL players as well as non-professional athletes as healthy controls. The study consists of a 90 minute PET scan, an MRI scan, memory testing, psychiatric interview, and bloodwork across two to three study visits. There is also an optional lumbar puncture. Volunteers are compensated for their time. For more information and to undergo a phone screening to determine eligibility please contact: Dr. Jennifer Coughlin, Co-Investigator: jcoughl2@jhmi.edu; 443-287-4701. PI: Martin G. Pomper, M.D., Ph.D. IRB # 00046416
 

NOTICE TO RESEARCHERS: If you are faculty in the Department of Psychiatry and Behavioral Sciences and you wish to post a recruitment ad on this page, please contact Donna Mennitto at dmennit2@jhmi.edu. You will need to send the IRB-approved recruitment language in paragraph form with a title of the study, the PI, contact information and the IRB Protocol Number. If you wish to make a flyer available to the public, send it in PDF or Word document form. You are responsible for IRB approval of the ad. Please be sure to contact us to remove the ad from this page when recruitment is complete. Thank you.

 

 

       

 

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