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Research Volunteers Needed

National Institute of Mental Health
A Participant's Guide to Mental Health Clinical Research
Click here to read

ADHD |  | Addictions | AnorexiaAnxiety DisordersAutism BulimiaFragile X Syndrome |  HEALTHY VOLUNTEERSHuntington's Disease | Memory Disorders | Mood Disorders | Obsessive-Compulsive Disorder | Pain | Parkinson's Disease |  Pediatric Obesity  | Psychosis | SchizophreniaSleep Disorders | Substance Abuse - Addictions | Tourette's Syndrome

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ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)

Adult ADD/ADHD
Men and women who have been diagnosed with ADD or ADHD are needed for a 2-day outpatient study at the Johns Hopkins School of Medicine in Baltimore, Maryland. Volunteers with ADHD who have used medications for the treatment of ADHD and those who have never used medications for the treatment of ADHD are needed. Volunteers should be between the ages of 18 and 40 and in general good health. Testing will take place at the Johns Hopkins Hospital and Bayview Medical Center. Study participants will receive compensation, and travel expenses will be covered. Earn up to $300 plus travel expenses. For more information, call 410-550-2588 or 410-550-5295 or email johnshopkins.lab@gmail.com. Collect calls are accepted. Principal Investigator: Una D. McCann, MD (IRB Number: NA_0073552)

Children With and Without ADHD - Ages 4–5
Dr. Mark Mahone and colleagues at the Kennedy Krieger Institute are recruiting children 4 or 5 years old to participate in a research study on learning and brain development in young children. We are looking for boys and girls with and without signs ADHD. The study involves two 3-hour visits of IQ, language, and behavioral tests, a Magnetic Resonance Imaging (MRI) scan of the brain, and behavioral practice sessions for MRI. None of these tests are harmful or painful. All testing is done free of charge. Participants receive a free summary of developmental testing, a picture of your child’s brain, and $50.00. For more information about this study, please contact Lisa Ferenc at (443) 923-4469 or by email (ferenc@kennedykrieger.org). Click here for a flyer. (IRB protocol #NA_00012868)  Download Flyer

Children With and Without ADHD - Ages 8–12  (MRI Research Study of Executive Functioning)
Dr. Stewart Mostofsky and colleagues at the Kennedy Krieger Institute are recruiting children between the ages of 8 and 12 years to participate in a research study of attention, response planning and inhibitory control.  This study is examining the brain basis of ADHD in children. We are looking for boys and girls with ADHD as well as children who do not have ADHD to participate as “comparison subjects”.  The study involves paper and pencil tasks, computer activities and a Magnetic Resonance Imaging (MRI) of the brain. None of these tests are harmful or painful.  There are no direct medical benefits from taking part in the study.  The study involves two days of testing and MRI.  Participants will receive $50.00 and a picture of their brain.  Parents will receive a report of the tests administered to their child.  All testing is done free of charge. For more information about this study, please contact Lindsay Koenig at (443) 923-9254 or by email (KoenigL@kennedykrieger.org). Click here for a flyer.  (IRB protocol #NA_00027428)

Children With and Without ADHD - Ages 8 -12  (MRI Research Study of Motor Skills)
Dr. Stewart H. Mostofsky of the Kennedy Krieger Institute and Johns Hopkins School of Medicine is recruiting children with and without Attention Deficit Hyperactivity Disorder (ADHD) between 8 and 12 years of age to participate in a study of attention, learning, memory, and motor skills.  The study involves paper and pencil tasks, computer activities, transcranial magnetic stimulation (TMS, a painless, non-invasive brain stimulation technique), and a MRI scan of the brain. None of the tests are harmful or painful and are done free of charge.  There are no direct medical benefits for participating in the study.  The duration of the study is two days. Participants will receive a $50 check and a picture of their brain.  Parents will receive a report summarizing the IQ testing administered to their child.  For more information about this study, please contact Lindsay Koenig at (443) 923-9254 or KoenigL@kennedykrieger.org. Click here for a flyer.  (IRB protocol #NA_00000292)

ANOREXIA

Anorexia Nervosa
Johns Hopkins researchers are conducting a placebo-controlled trial to examine the effectiveness of a research medication in the treatment of adults with anorexia nervosa. Participants will be offered 16 weeks of medication (active or inactive) and weekly outpatient medical monitoring by a psychiatrist. The treatment will be provided at no cost. To participate, you must have anorexia nervosa, be 18-55 years old, be medically stable for outpatient treatment, complete assessments (interviews, questionnaires and medical evaluations) at intervals throughout the 16-week study and at 1- and 2-month follow-ups. Information gathered will remain confidential. Call (410) 955-3863 for more information (NA_00040741) Site Principal Investigator: Angela S. Guarda, M.D. Click here for flyer.

 ANXIETY DISORDERS

Children’s Headache and Anxiety Management Program (CHAMP)
We are now enrolling participants in a study, funded by the Migraine Research Foundation, that is evaluating the feasibility and effectiveness of a family-based cognitive-behavioral treatment (CBT) for reducing chronic headaches and excessive symptoms of anxiety in youth (7-17 years old). No medication is being evaluated in this study and all participants may continue to take their prescribed medication.  A total of 30 families will be randomized to receive 8-weeks of CBT or relaxation training. Children’s’ symptoms will be closely monitored at pre-treatment, post-treatment, and at a one-month follow-up evaluation. All evaluations and treatment are provided at no cost. If you would like more information, please contact Dr. Kelly Drake at 410-955-8021 or kdrake2@jhmi.edu. (JHMIRB protocol # NA-00019444) Principal Investigator: Golda S. Ginsburg, Ph.D; Co-Investigators: Kelly L. Drake, Ph.D., Eric Kossoff, MD 

Psilocybin and Cancer: A Scientific Study of States of Consciousness
We are seeking cancer patients with anxious or depressed mood to participate in a scientific study of state of consciousness brought about by the entheogen psilocybin, a psychoactive substance found in mushrooms used as a sacrament in some cultures, given in a comfortable, supportive setting. Questionnaires and interviews will be used to assess the effects of the substance on consciousness, mood, and behavior. Volunteers enrolled in the study will receive careful preparation and two sessions in which they will receive psilocybin. Structured guidance will be provided during the session and afterwards to facilitate integration of the experiences. Volunteers must be 21 to 70 years old, have no personal history of severe psychiatric illness or recent history of alcoholism or drug abuse, have someone willing to pick them up and drive them home at the end of the two psilocybin sessions (around 5:00 PM), and must live within travel distance of the Johns Hopkins Bayview Medical Center in Baltimore. If you would like to discuss the possibility of volunteering, please call 410-550-5990 and ask for Mary, the study's research coordinator. Confidentiality will be maintained for all applicants and participants. Roland R. Griffiths, Ph.D. is the principal investigator. More information available at www.bpru.org/cancer. Click here for PDF flyer. (IRB Protocol #NA_00001390)

AUTISM

Motor Skill Learning in Autism: Assessment and Treatment of Altered Patterns of Learning - Ages 8-12
Dr. Stewart H. Mostofsky of the Kennedy Krieger Institute and Johns Hopkins School of Medicine are recruiting children with high-functioning autism between 8 and 12 years of age to participate in a study of attention, learning, memory, and motor skills.  The study involves paper and pencil tasks, computer activities, a MRI of the brain, and a session of transcranial direct current stimulation, a painless brain stimulus technique in which a small current is passed through a brain region for about 20 minutes. None of the tests are harmful or painful and are done free of charge.  There are no direct medical benefits for participating in the study.  The duration of the study is two to three days. Participants will receive a $50 check and a picture of their brain.  Parents will receive a report summarizing the IQ testing administered to their child.  All testing is done free of charge.  For more information about this study, please contact Lindsay Koenig at (443) 923-9254 or by email at KoenigL@kennedykrieger.org. Stewart H. Mostofsky, Ph.D. is the Principal Investigator. Click here  for a PDF flyer. (IRB Protocol # NA_00027073)

BULIMIA

Bulimia Nervosa
We are seeking female subjects (18 yrs old and older) with bulimia nervosa to participate in an outpatient research study. This study requires you to drink a chocolate shake, place your hand in an ice bath, and have your blood drawn. Participation involves an initial 30 min screening and two (approx. 3.5 hour each) morning sessions. You will be paid up to $120 for your participation. For more information call Dr. Margaret Seide (410)-955-8003 or email at mseide2@jhmi.edu Principal Investigator: Angela S. Guarda, M.D. Click here for flyer (NA_00032632)

FRAGILE X SYNDROME

Investigational Drug Study for Children with Fragile X Syndrome
Kennedy Krieger Institute is looking for children, ages 5 through 11 years, with fragile X syndrome to participate in a research study.  This study is being conducted by centers across the country to help determine if the investigational drug arbaclofen is an effective treatment for social withdrawal symptoms associated with fragile X syndrome. This study will also assess whether arbaclofen is safe and tolerated by individuals with fragile X syndrome. The study involves visits which will consist of physical and medical exams (including blood draws and ECG testing) and behavioral assessments. For females, there will be a urine pregnancy test at every visit. The risks of this study include common side effects associated with arbaclofen such as drowsiness, dizziness, weakness and fatigue (tiredness). Some participants may also find medical procedures such as blood draws, electrocardiogram (ECG), urine testing and physical examination upsetting or uncomfortable. There are no direct medical benefits for participating in this study. The study will require up to 6 visits (each lasting 2-4 hours) over an 18-week period. Up to 12 follow-up telephone calls will be conducted in between visits. For each completed visit, participants will receive $50 compensation for their time and travel expenses. All testing is done free of charge.For more information about this study, please contact the Study Coordinator at (443) 923-7619 or by email at ResearchTrials@kennedykrieger.org Study Sponsor: Seaside Therapeutics, Principal Investigator: Dr. Michael Johnston (IRB Protocol #: NA_00050003) www.clinicaltrials.gov (#NCT01325220) Download flyer
 
Investigational Drug Study for Adolescents and Adults with Fragile X Syndrome
Kennedy Krieger Institute is looking for adolescents and adults, ages 12 through 25 years, with fragile X syndrome to participate in a research study.  This study is being conducted by centers across the country to help determine if the investigational drug arbaclofen is an effective treatment for social withdrawal symptoms associated with fragile X syndrome. This study will also assess whether arbaclofen is safe and tolerated by individuals with fragile X syndrome. The study involves visits which will consist of physical and medical exams (including blood draws and ECG testing) and behavioral assessments. For females, there will be a urine pregnancy test at every visit. The risks of this study include common side effects associated with arbaclofen such as drowsiness, dizziness, weakness and fatigue (tiredness). Some participants may also find medical procedures such as blood draws, electrocardiogram (ECG), urine testing and physical examination upsetting or uncomfortable. There are no direct medical benefits for participating in this study. The study will require up to 6 visits (each lasting 2-3 hours) over an 18-week period. Up to 14 follow-up telephone calls will be conducted in between visits. For each completed visit, participants will receive $50 compensation for their time and travel expenses. All testing is done free of charge. For more information about this study, please contact the Study Coordinator at (443) 923-7619 or by email at ResearchTrials@kennedykrieger.org. Study Sponsor: Seaside Therapeutics. Principal Investigator: Dr. Walter Kaufmann (Protocol #: NA_00047949  www.clinicaltrials.gov (#NCT01282268). Download flyer.

HUNTINGTON'S DISEASE

Clinical Trial (Phase 2) of Dimebon
The Huntington Study Group (HSG) is conducting a study of the research medication Dimebon in persons 18 years of age or older who have mild to moderate Huntington’s disease (HD). The DIMOND trial is designed to determine safe and tolerable doses of Dimebon and also to determine the effect of Dimebon on cognitive (thinking) and motor (movement) signs and overall functioning of subjects with HD. Approximately 15 research centers in the United States (of which Johns Hopkins is one) and in the United Kingdom will enroll up to 90 research subjects and will last about 3 months. The study will enroll research subjects with early to moderate signs of HD who are independently ambulatory (walking) and self-sufficient in activities of daily living, such as eating, dressing, and bathing. Enrollment will begin in the Summer of 2007. The study is sponsored by Medivation, Inc. If you are interested in participating, call the Huntington Study Group toll free 1-800-487-7671. Click here for the Baltimore Huntington's Disease Center. (IRB Protocol # NA_00012285)

MEMORY DISORDERS

Alzheimer’s Disease/Brain Imaging Study
We are seeking participants for a brain imaging clinical research study. To join, you must be between 50-80 years of age, have a diagnosis of Alzheimer’s Disease, have a study partner who is willing and able to attend study visits and answer questions about you, and meet other study requirements that relate to your health. We will evaluate investigational brain imaging agents called radiotracers used for PET (Positron Emission Tomography) Scan imaging of the brain. We want to learn if one of these radiotracers might help test new medicines and gain a better understanding of Alzheimer’s Disease. If you are eligible, you will be compensated for your time and participation in the study. To find out more about this opportunity, please contact us at 410-955-0210.  Principal Investigator: Dean F. Wong, MD, PhD. (IRB Number _IRB00035115)

Mild Cognitive Impairment Study
Are you more forgetful lately? Do you have trouble with the names of people you’ve met recently? Do you get lost in new places? Do you have a greater tendency to misplace things? Do other people notice that you are forgetful? If you are age 55 or over, having memory problems, not taking antidepressant medication and in good health, you may be eligible to participate in a research study. Qualified people will participate at no cost to them and will be compensated for their time and transportation. For more information about the research study, please call us at 410-550-4192 or email us at BrainImagingStudy@lists.johnshopkins.edu. (Principal Investigator: Gwenn Smith, PhD, IRB Protocol No: NA_00026190) Download flyer.

Depression in Alzheimer’s Disease Study
People with Alzheimer’s disease can feel depressed. This condition is treatable with medication. Symptoms of depression can be loss of interest, feelings of hopelessness, persistent aches and pains, feeling sad, anxious or empty, loss of appetite, irritability, restlessness, insomnia or even excessive sleeping. We are conducting a research study to examine this and to see if a drug called venlafaxine may help. If you or someone you know is diagnosed with Alzheimer’s disease and experiencing feelings of depression, they may be eligible to participate in this study. If you are interested in learning more about this study please call Jane Pollutra 410-550-4258. Paul Rosenberg, M.D. Principal Investigator (JHU IRB Application #: NA_00066043)

Preliminary Study of Carvedilol for the Treatment of Alzheimer’s Disease
This study is being done to see if the anti-hypertensive drug carvedilol can improve thinking and memory in people with Alzheimer’s disease. Carvedilol is approved by the Food and Drug Administration for the treatment of hypertension (high blood pressure) and ventricular dysfunction. substances, which control the muscles in the heart. In an observational study of people with Alzheimer’s disease, there was some indication that people who took beta-blockers had a slower rate of decline in their thinking and memory. In studies using mice, daily doses of carvedilol decreased some of the toxic chemicals in the brain that are believed to cause Alzheimer’s disease. These initial observations suggest that carvedilol, by having a beneficial effect on vascular conditions in the brain, may decrease certain toxins in the brain. If you are interested in learning more about this study please call Jane Pollutra 410-550-4258. Paul Rosenberg, M.D. , Principal Investigator (JHU IRB Application #.: NA_00035546)

Oral Glucose Tolerance Test for Alzheimer’s Disease Biomarker Development
The purpose of this research is to find if there is a relationship between a chemical in the blood, which may be related to memory problems, and the body’s hormonal response from the pancreas, gut, and fat tissue after an oral glucose tolerance test. People with and without memory problems may join this study. The study involves a memory screening test and an oral glucose tolerance test. The results of these tests will help us with our research study related to memory, aging, and hormones. If you are interested in learning more about this study please call Jane Pollutra 410-550-4258. Esther Oh, M.D., Principal Investigator (JHU IRB Application No.: NA_00014837)

Memory & Aging Study
The Johns Hopkins Memory Center is currently conducting a study of the differences between normal aging, mild memory problems, and the onset of memory disorders like Alzheimer’s Disease. If you choose to participate in the Memory and Aging Study, you and a study partner will be invited to our clinic for a 2-3 hour assessment including memory testing, physical exam, and blood samples. We will ask you and your study partner questions about your daily functioning. You will return to our clinic once a year for an annual physical exam and memory testing. People, 60 years old or older, with or without memory problems, can participate in this study. If you are interested in learning more about this study please call Carolyn Koch at 410-550-9021. Constantine Lyketsos, MD, MPH,, Principal Investigator (JHU IRB Application No: NA_00045104)

Levetiracetum and Memory Function - Clinical Trial
A research study is being conducted at Johns Hopkins University to evaluate the daily use of an FDA approved medication in improving memory. For this study we are looking for older adults (50 to 85 years) who are interested in participating in memory research. Participation includes four visits to the Johns Hopkins Hospital where you may undergo memory testing, MRI scans, and be asked to take the study medication twice a day for a maximum of two weeks. The study may provide transportation to and from the hospital if needed, and participants will receive a total of $225 dollars at the end of the four study visits. If you are between the ages of 50 and 85, are able to have an MRI, and believe you are experiencing memory loss (or have been diagnosed with mild cognitive impairment), you may qualify for this study! To learn more, please contact the study coordinator, Caroline Speck, at 410-955-5057 or cspeck1@jhmi.edu Principal Investigator: Gregory Krauss, M.D. (Protocol Number: NA_00030573). Co-investigator: Arnold Bakker, Ph.D.

MOOD DISORDERS

First Episode Psychosis
Longitudinal Characterization of Molecular Biomarker Changes Over the Early Course of Psychotic Disease
Researchers are seeking individuals diagnosed with a psychotic disorder to participate in a research study being done to study the cells of patients with psychotic disorders. Your participation may help improve the treatment of psychotic disorders for patients like you. This study is a longitudinal study over the course of three years (only a few visits required per year): you can earn up to $1740. To be eligible for this study, you must be between 13-35 years of age with a psychotic disorder diagnosis – this may include schizophrenia, bipolar disorder, and mood disorders. Qualified participants have the option of undergoing: blood draw, skin biopsy, nasal biopsy, lumbar puncture, and two sessions of brain scanning with MRI technology. To learn more, please call Candice at 443-287-4986 or email at cford15@jhmi.edu. (NA_00082086, Principal Investigator: Akira Sawa, MD, PhD)

Interpersonal Psychotherapy for Youth with Severe Mood Dsyregulation
We are conducting a research study at Johns Hopkins that evaluates the effectiveness of a specific psychotherapy for adolescents, between the ages of 13 and 17, with severe mood dysregulation (SMD).  Youth with SMD have chronic anger and irritability, disproportionate emotional reactions (rages/outbursts/fits), and other associated symptoms (problems with sleep or concentration, restlessness, talkativeness).  Because of the mood symptoms, these youth may have difficulties with relationships.  The goal of the study is to improve mood and relationships through interpersonal psychotherapy.  As part of the study, your teen will receive a free comprehensive evaluation and may earn up to $135 in gift cards.   Parents may earn up to $135 for participation.  For more information please contact the Principal Investigator, Leslie Miller, M.D. at (410) 550-9014 or email  jgalang1@jhmi.edu.  (IRB protocol NA_00083893)  Download flyer

Translational Cellular Models for Mood Disorders 
If you have been diagnosed with Bipolar Disorder: Type I, you may qualify to participate in a research study at the Johns Hopkins Mood Disorders Center. This study would potentially involve an interview with our study physician, a blood draw, a small (2mm) skin sample, and a nasal sample. Compensation of up to $275 is available for participation. If you are interested in participating, please contact our research staff at 443-287-2981 or email moods@jhu.edu. Principal Investigator: Fernando Goes, M.D. (IRB Protocol #NA_00044928)

Clinical Trial for TMS with Mood Stabilizers in Bipolar Depression
If you are between the ages of 22-68, currently suffering from Bipolar depression, and are currently taking a mood stabilizer you may be eligible to participate in a research study on deep Transcranial Magnetic Stimulation (dTMS). This study is being conducted to evaluate the safety and effectiveness of the H-Coil Transcranial Magnetic Stimulation (TMS) in treating bipolar depression. Participation involves 25 visits over 8 weeks. There are up to three weeks for screening visits to determine eligibility. During this time participants will also need to be gradually taken off of psychiatric medications except for a mood stabilizer. Once eligible, there are 8 weeks of the study procedure including 2 follow-up visits. Participants will have a 50% chance of receiving real TMS or sham TMS once a day, 5 days per week for 4 consecutive weeks, then 3 times during week 5, and once during week 6.  Participant safety will be monitored, and each participant will be asked questions pertaining to their mood and anxiety. There will be compensation for participating in this study. For more information please call 410-614-1732. The principal investigator is Dr. Irving Reti. (IRB Protocol NA_00045624).

Pharmacogenomics of Mood Stabilizer Response in Bipolar Disorder (PGBD)
We are looking for adults ages 18 and older who have bipolar disorder and are not pregnant.  Our purpose is to stabilize participants with bipolar disorder on lithium alone in order to learn which genes are associated with a good response to medication. The study lasts up to 2.5 years, and involves clinician assessments, questionnaires, routine lab work, and taking a blood sample for DNA.  You will be paid for participating in this research.  You will receive ongoing care during the course of the study from our study psychiatrist, Dr. Francis Mondimore, at the Johns Hopkins Bayview Mood Disorders Clinic.  Or, you can continue to receive your clinical care from your current psychiatrist in close consultation with Dr. Mondimore while you participate in the study.  For more information, please call 410-550-1652 or email moods@jhu.edu.  Principal Investigator: Peter Zandi, PhD, MPH, MHS (IRB Protocol NA_00043300). Click here for PDF brochure.

Bipolar Disorder Research Study
Have you been diagnosed with bipolar disorder?  Do you sometimes have trouble concentrating?  If so, you may qualify for a 16 - 18 week research study for treatment of bipolar disorder.  We are looking for adults between the ages of 18 and 65 who are currently in treatment with an outpatient psychiatrist.  Volunteers will receive study medication, laboratory tests and will be compensated for their participation.  For more information, please call (410) 502-2586 or email moodtrials@jhmi.eduJennifer Payne, MD. is the principal investigator.  (IRB Protocol #NA_0009034)

Mood Disorders and Pregnancy Study
The Johns Hopkins Women's Mood Disorders Center is currently seeking women who have a history of depression or bipolar disorder to participate in a naturalistic study that would follow them during pregnancy and the postpartum period.  Participants may enter during any trimester and would have visits during each trimester and 1 week, 1 month, and 3 months postpartum.  Volunteers will be compensated for their participation.  For more information, please call 410-502-2586 or email moodtrials@jhmi.eduJennifer Payne, MD is the principal investigator.  (IRB Protocol #NA_00008149)

Child Gaining Weight on Medication?
Dr. Mark Riddle and colleagues in the Johns Hopkins Division of Child and Adolescent Psychiatry are conducting a treatment research study funded by the National Institute of Mental Health. The goal of the study is to find improved treatments for youth who have a have gained weight while taking antipsychotic medication. We are currently seeking children ages 8-17 who are taking olanzapine (Zyprexa®), quetiapine (Seroquel®), risperidone (Risperdal®), aripiprazole (Abilify®), asenapine (Saphris®, Sycrest®), iloperidone (Fanapt®, Fanapta®, Zomaril®), lurasidone (Latuda®), or ziprasidone (Geodone®) and have gained a significant amount of weight in the past year while taking one of these medications. Consenting children who meet eligibility criteria will receive a medical and psychiatric evaluation and will be assigned to one of three groups: 1) stay on current medication, 2) switch from current medication to aripiprazole (Abilify®) or perphenazine (Triafon®), 3) stay on current medication and add metformin (Glucophage®). Participants receive study-related evaluations and treatment at no cost. For further information call 410-614-5174 or email impact@jhu.edu . Principle Investigator:Mark Riddle, MD (JHU IRB #00017204)  Click here for PDF brochure.

Mood Disorders and Pregnancy Study
The Johns Hopkins Women's Mood Disorders Center is currently seeking women who have a history of depression or bipolar disorder to participate in a naturalistic study that would follow them during pregnancy and the postpartum period.  Participants may enter during any trimester and would have visits during each trimester and 1 week, 1 month, and 3 months postpartum.  Volunteers will be compensated for their participation.  For more information, please call 410-502-2586 or email moodtrials@jhmi.edu. Jennifer Payne, MD.is the principal investigator.  (IRB Protocol #NA_00008149)

> Geriatric Depression Study
Are you over 60 and feeling depressed? Symptoms of depression in older adults are common yet often go undetected. Symptoms could include feelings of sadness or hopelessness, loss of energy, inability to enjoy pleasurable activities, changes in appetite or sleeping patterns, or poor concentration/memory. If you are feeling depressed, not taking antidepressant medication and in good physical health you may be eligible to participate in a research study involving treatment. Qualified people will participate at no cost to them and will be compensated for their time and transportation. For more information about the research study, please call us at 410-550-4192 or email us at BrainImagingStudy@lists.johnshopkins.edu . Download PDF flyer. Principal Investigator: Gwenn Smith, PhD (IRB Protocol No: NA_00021615)

OBSESSIVE-COMPULSIVE DISORDERS

Cytokine levels and genes in Obsessive-Compulsive Disorder: A Longitudinal Study
This study aims to understand how OCD manifests in children over one-year, using monthly follow-up assessments. Some children are known to have dramatic exacerbations, others will have a more stable course of symptoms. Both groups will be compared for immune markers (cytokines). It is hypothesized that children with dramatic exacerbations have an immune difference compared to other children with OCD, measured by cytokine levels in blood. Marco Grados, M.D., M.P.H is the principal investigator. Call 443-287-2291 or email mjgrados@jhmi.edu. (IRB Protocol # NA_00001439. Approved 01/11/2007)

Genetics of Obsessive-Compulsive Disorder (Adults and Children)
We are investigating genetic factors which may increase the susceptibility to OCD. Recent advances in molecular biology and statistical genetics make it possible to identify and describe specific genes that may cause complex diseases such as OCD. Individuals with OCD are invited to participate in the study. Participants are given a confidential interview about their medical history and will be asked to provide a small sample of blood. Participants do NOT need to travel. Confidentiality of all information is assured. Families may be referred by a clinician or they may contact us directly. Gerald Nestadt, M.D., M.P.H. is the principal investigator. Call 410-614-4942. (Collect calls accepted) or email KRISTA K VERMILLIONkvermil1@jhmi.edu (IRB Protocol # 91-11-20-02)

PAIN

Temporomandibular Joint Disorders (TMJD), Pain, and Sleep
Do you have jaw muscle pain?  Researchers at Johns Hopkins are looking for female volunteers with Temporomandibular Joint Disorders (TMJD) pain to participate in a research study funded by the National Institutes of Health to investigate how sleep and unhelpful thoughts about TMJD impact pain sensitivity and symptoms related to TMJD. You may be eligible if you: Are a female between 18-60 years of age, have had jaw muscle pain for 3 months or more, have sleep difficulties. Study Includes: A dental evaluation for TMJD, completing interviews and questionnaires, 2 ambulatory sleep studies that you can do in your own home, completing sensory testing procedures, 8 total study visits over 3 months and 1 telephone follow-up 3 months after completing the study. Earn up to $650.00. Please contact: Mary Redding at 410-550-8099. Principal Investigator: Jennifer Haythornthwaite, M.D. (Study #: NA_00070364) Download flyer

PARKINSON'S DISEASE

Parkinson’s Disease Clinical Trial For People with Mild-Cognitive Impairments
Investigators at the Johns Hopkins Hospital seek volunteers with Parkinson’s disease, over 45-80 years old, for participation in a multi-site research study funded by EMD Serono, Inc. If you have difficulty with your memory, you may qualify for this study. Please call Melissa Gerstenhaber, R.N. at (410) 614-1242. Principal Investigator: Gregory Pontone, M.D.      (IRB# NA_00040875). Click here for PDF flyer.

Database for Future Research Studies
Investigators seek volunteers with Parkinson's disease and volunteers without neurological disease over age 21 who agree to be contacted for future research studies. This does not obligate you to participate in any study you many be contacted about. Please call Melissa Gerstenhaber, R.N. at (410) 614-1242. Gregory Pontone, M.D. is the principal investigator. (IRB Protocol # 98-05-08-06). Click here for a PDF flyer.

PEDIATRIC OBESITY

Eating and Impulsivity Study- Children aged 8-14 years
We are recruiting children between the ages of 8 and 14 years to participate in a study examining impulsivity ( whether kids act before they think), eating behavior and weight. The study involves a single visit, lasting  from 4 to 6 hours. The visit includes a diagnostic interview, psychological testing , weight and height measurement.  Testing is free. Reimbursement for time and inconvenience is $100; parking voucher provided.  For more information please contact Principal Investigator Shauna P. Reinblatt, M.D. at 410-550-9947. Please click here to download a PDF flyer (IRB Protocol #  NA_00020561).

PSYCHOSIS

First Episode Psychosis
Longitudinal Characterization of Molecular Biomarker Changes Over the Early Course of Psychotic Disease
Researchers are seeking individuals diagnosed with a psychotic disorder to participate in a research study being done to study the cells of patients with psychotic disorders. Your participation may help improve the treatment of psychotic disorders for patients like you. This study is a longitudinal study over the course of three years (only a few visits required per year): you can earn up to $1740. To be eligible for this study, you must be between 13-35 years of age with a psychotic disorder diagnosis – this may include schizophrenia, bipolar disorder, and mood disorders. Qualified participants have the option of undergoing: blood draw, skin biopsy, nasal biopsy, lumbar puncture, and two sessions of brain scanning with MRI technology. To learn more, please call Candice at 443-287-4986 or email at cford15@jhmi.edu. (NA_00082086, Principal Investigator: Akira Sawa, MD, PhD)

SCHIZOPHRENIA

First Episode Psychosis
Longitudinal Characterization of Molecular Biomarker Changes Over the Early Course of Psychotic Disease
Researchers are seeking individuals diagnosed with a psychotic disorder to participate in a research study being done to study the cells of patients with psychotic disorders. Your participation may help improve the treatment of psychotic disorders for patients like you. This study is a longitudinal study over the course of three years (only a few visits required per year): you can earn up to $1740. To be eligible for this study, you must be between 13-35 years of age with a psychotic disorder diagnosis – this may include schizophrenia, bipolar disorder, and mood disorders. Qualified participants have the option of undergoing: blood draw, skin biopsy, nasal biopsy, lumbar puncture, and two sessions of brain scanning with MRI technology. To learn more, please call Candice at 443-287-4986 or email at cford15@jhmi.edu. (NA_00082086, Principal Investigator: Akira Sawa, MD, PhD)

Cell and MRI Study of Patients with Schizophrenia
Do you have Schizophrenia? Are you between 18-65 years of age? You may be the perfect candidate for our study! Researchers are seeking individuals diagnosed with Schizophrenia to participate in a research study being done to study the cells of patients with schizophrenia. The study takes place over the course of two weeks, during which you can earn a compensation of up to $500! Qualified participants will have the option of undergoing neuropsychological testing with a study team member, a blood draw, a nasal biopsy, and three sessions of brain scanning using MRI technology.To learn more, please call Cecilia Higgs, chiggs@jhmi.edu 443-287-2981. (Principal Investigator: Akira Sawa, M.D., Ph.D., (IRB # NA_00037204)

Using a Novel PET Ligand for Imaging Brains 
Earn up to $350 in only three visits! The purpose of our study is to validate the use of a new technique to image inflammation in brains of patients with recent onset Schizophrenia.  In particular, we aim to image inflammatory activation using Positron Emission Tomography (PET). We are recruiting patients with recent onset Schizophrenia (and in the first five years of the disease). To be eligible for the study, you must be over 18 years old. As a study participant, you will be asked to undergo preliminary tests including: a blood draw, a urine sample, a pregnancy test (if applicable), an EKG test (painless measurement of your heart’s electrical activity), neuropsychological testing and a physical exam. In addition, we will schedule 2 imaging visits, 1 MRI and 1 PET scan visit. Participants will receive compensation of up to $350, paid in segments after completion of each portion of the study. To learn more, please call Dr. Coughlin at 443-287-4701or email at jcoughl2@jhmi.edu. (NA_00023849, Principal Investigator: Martin Pomper, M.D., Ph.D)

Schizophrenia Study 
The goal of this study is to gain a better understanding of schizophrenia. To be eligible for the study, participants must have schizophrenia, schizoaffective or related disorders, be willing to have a blood sample drawn, be 14 years or older, have no history of stroke, brain tumor or serious brain injury, not consume alcohol or street drugs daily and speak English. Participation in the study involves release of medical records, a clinical interview and blood sample. Participants will be paid $20 for their time. If you or someone you know might be interested in the study or have questions about the study, please call Nadine Yoritomo, R.N. at 410-502-5887 or email schizophrenia@jhmi.edu. Principal Investigator: Russell Margolis, M.D. (RPN # NA_00009162)

SLEEP DISORDERS

Temporomandibular Joint Disorders (TMJD), Pain, and Sleep
Do you have jaw muscle pain?  Researchers at Johns Hopkins are looking for female volunteers with Temporomandibular Joint Disorders (TMJD) pain to participate in a research study funded by the National Institutes of Health to investigate how sleep and unhelpful thoughts about TMJD impact pain sensitivity and symptoms related to TMJD. You may be eligible if you: Are a female between 18-60 years of age, have had jaw muscle pain for 3 months or more, have sleep difficulties. Study Includes: A dental evaluation for TMJD, completing interviews and questionnaires, 2 ambulatory sleep studies that you can do in your own home, completing sensory testing procedures, 8 total study visits over 3 months and 1 telephone follow-up 3 months after completing the study. Earn up to $650.00. Please contact: Mary Redding at 410-550-8099. Principal Investigator: Jennifer Haythornthwaite, M.D. (Study #: NA_00070364) Download flyer
 
Sleep, Pain, and Aging Studies
Researchers at Johns Hopkins University are looking for individuals to participate in research examining the relationship between sleep and pain due to knee arthritis. You may be eligible if you: are 50 years or older and are generally healthy with no serious medical conditions. Study includes a clinical sleep evaluation and screening visit, one overnight sleep study conducted in your home, x-rays of the knee, pain and sensory testing, optional blood draws and physical tests. Volunteers with knee arthritis and insomnia may be eligible for additional studies designed to treat insomnia and improve pain. All examinations are free of charge. Compensation up to $870. If interested, please call (410)550-7906, or visit http://www.sleeplessinbaltimore.com Principal Investigator: Michael T. Smith, Ph.D. (IRB Protocol NA_00011802)

Insomnia with Knee Osteoarthritis - Behavioral Modification Therapy
Volunteers are needed for a research study to evaluate cognitive-behavioral (non-drug) treatment for insomnia in patients with osteoarthritis of the knee. To participate, you must be 35 years or older. All examinations, parking, and tests are provided at no cost. Compensation is provided. Call 410-550-7906. Principal Investigator: Michael T. Smith, Ph.D. (IRB Protocol NA_00011802) Click here for PDF flyer.

SUBSTANCE ABUSE / ADDICTIONS

Do You Smoke?
A NIH-funded research project is being done to learn more about how nicotine and the medication Varenicline affect the brain and behavior. Varenicline is FDA-approved for smoking cessation treatment and marketed as Chantix, a drug used to help people quit smoking. We also want to learn more about the genetic and environmental risk factors for nicotine addiction. The study requires three visits, one of which includes staying on the research unit at Johns Hopkins Hospital for six nights. Compensation up to $695 will be provided for study completion. For more information, call  IPSAR at 410.502-5433 Principal Investigator:  Mary E. McCaul, PhD. (Protocol # NA_00031348)   Download Flyer

Nicotine Patch Research Study
This research study is being done to learn more about brain changes during active smoking and nicotine withdrawal. We will be studying the brain using noninvasive imaging in both smokers and non-smokers. Participants will complete 2 visits, one of which includes staying on a research unit for 3 nights. Compensation up to $600 will be provided for study completion. For more information, call 410.502-5433. Principal Investigator: Mary E. McCaul, PhD   Download Flyer
(RPN:  NA_00036996)

Help Cutting Down Caffeine
Have you tried unsuccessfully to quit or cut down caffeine use? Do you think you may be addicted to caffeine? If you are between the ages of 18 and 70 and are seeking help to quit or reduce caffeine, you may be eligible for caffeine treatment research at Johns Hopkins Bayview at no monetary cost to you. Principal Investigator: Roland Griffiths, Ph.D. Study Number NA_00051415 Download Flyer

Opioid users (heroin or prescription pain relievers) looking for withdrawal treatment
Are you 18-60 years old, currently addicted to heroin or prescription pain relievers and seeking treatment? Researchers at Johns Hopkins Bayview Medical Center are conducting an inpatient research study to test an investigational medication for opioid withdrawal.  Participation requires you to live on our Clinical Research Unit for up to 28 days. If you qualify, you will receive study-related care at no cost and you will be compensated. Compensation of up to $700. Call 410-550-0490 for phone screening. Principal Investigator:  Eric Strain, MD (Protocol # NA_00037871). Download Flyer

Opiate Users Seeking Treatment
Johns Hopkins University is conducting a research study for people who are trying to stop using opiates, such as heroin and Oxycontin.  We are testing a medication that may help people quit. The study lasts about 22 days and requires 8 visits. All volunteers will receive a form of buprenorphine (similar to Suboxone) as part of the study.  All medications and study-related activities including physical exam, clinical labs, and ECGs, are provided at no cost and health insurance is not required.  Scheduling is flexible and you can earn up to $460 for your participation. For more information, please call 410-550-1206. Principal Investigator:  George Bigelow, Ph.D. (IRB Protocol # NA_00086546) Download Flyer

Investigational Research on Heavy Drinking
Are you 21 to 65 years old and want to reduce your drinking? Researchers at the Johns Hopkins Bayview Campus are conducting a research study testing a medication that may help people reduce their drinking. Participation requires 9 visits over about 16 weeks. Participation is confidential.  Compensation is provided for your time and travel. 

Cocaine Users Needed
Cocaine Users Needed. Healthy men and women that are at least 18 years old who use cocaine are needed for a research study at the Johns Hopkins Bayview Medical Center. The study involves questionnaires and computer tasks assessing decision making. This research study requires a screening visit, and a same day experimental session. The total visit will last approximately 3-4 hours. Compensation is $30 for screening and $45 for the experimental session ($75 total). This is NOT a treatment study. For more information please call 410-550-9497. Principal Investigator:  Matthew W. Johnson, Ph.D. Application # NA_00074941. Download Flyer

Attention cigarette smokers
The Smoking Clinic at The Johns Hopkins Bayview Medical Center is currently recruiting adult research volunteers who are interested in trying new cigarettes.  This research does not provide treatment and is not for people trying to quit smoking.  Research participation requires visits to the Johns Hopkins Bayview Medical Center 1 or 2 times each week.  Scheduling is flexible and you will be compensated for your time.   If you are interested call us at 410-550-5143 for details.  Again, the Smoking Clinic at the Johns Hopkins Bayview Medical Center is looking for daily cigarette smokers to participate in research studies.  Call us at 410-550-5143 for details.  All calls are confidential.  Download Flyer

Buprenorphine, Suboxone and Methadone Study
Volunteers between the ages of 18 and 55 who are prescribed buprenorphine or methadone are needed for a research study at Johns Hopkins Bayview Medical Center. Volunteers must not be using any other drugs. Participants also must be healthy, pain free, and willing to stay overnight on a research unit. Compensation is provided up to $375. Please call 410-550-9494 to see if you may qualify. Principal Investigator: Andrew Tompkins, M.D. (NA_00071459) Download flyer.

 Investigational Research on Heavy Drinking
Do you have a drinking problem? Researchers at the Johns Hopkins Bayview campus are conducting a research study testing a medication that may help people reduce their drinking. Participation requires 9 visits over about 16 weeks. Participation is confidential. Compensation will be provided for your time. Call 410-550-1916 for more information and to complete a 15-minute phone interview to determine whether you might be eligible. Principal Investigator: Eric C. Strain, M.D. (Study Number: NA_00075518)

Marijuana Treatment Study
Marijuana users 18-55 years old are needed to take part in a research study of marijuana use and sleep at Johns Hopkins. Study volunteers will complete a 12-week program designed to help stop use of marijuana.  Study includes investigational medication and advanced assessments of sleep. Call (410) 550-2695 for details. Principal Investigator: Ryan Vandrey, Ph.D. Study Number: NA_00068969

Effects of Prescription Oral Methamphetamine on Decision Making
Healthy men and women ages 21-55 who have used stimulants to get high (such as cocaine, methamphetamine, or amphetamine) in the last six months are needed to participate in a research study about effects of prescription oral methamphetamine on decision making at the Johns Hopkins Bayview Medical Center. This is not a treatment study. This study requires one 4-5 hour screening visit and three overnight sessions lasting about 32 hours each. During each session, you will be required to remain overnight at a residential unit.Earn up to $525 for completing the study. For more information please call 410-550-9497. Principal Investigator: Matthew W. Johnson, Ph.D. (IRB Protocol NA_00041057). Download flyer

Smokers Wanting to Quit
Johns Hopkins University School of Medicine is seeking cigarette smokers who would like to quit smoking for participation in a scientific research study. The study involves ingestion of psilocybin in a comfortable, supportive setting. Psilocybin is a psychoactive substance found in psychedelic mushrooms that have been used as a sacrament in various cultures. Some research studies have suggested that psychedelics, when administered under interpersonally supportive and well-prepared conditions, may be effective in helping people overcome addictions. Cognitive behavior therapy and ongoing interpersonal support will be integrated with psilocybin sessions in order to help participants quit smoking. Questionnaires, interviews, and biological measures of smoking will be used to assess the treatment’s effects on consciousness, mood, and smoking. Volunteers enrolled in the research study will receive careful preparation and 3 sessions in which they will receive psilocybin. Structured guidance will be provided during the sessions and afterwards to facilitate integration of the experiences. Volunteers must be between the ages of 21 and 65, have no personal history of severe psychiatric illness, or recent history of alcoholism or drug dependence other than cigarettes, have someone willing to pick them up and drive them home at the end of the 3 psilocybin sessions (around 5:00 PM), and must live within travel distance of the Hopkins Bayview campus in Baltimore. If you would like to discuss the possibility of volunteering, please call 410–550–1972 and ask for Albert, the study’s research coordinator. Confidentiality will be maintained for all applicants and participants. Principal Investigator: Matthew W. Johnson, Ph.D., (Protocol: NA_00016166) Download Flyer

Methamphetamine Users
Methamphetamine users are needed for a medical research study. Volunteers should be between the ages of 18-45, in good general health and taking no regular medications. Testing will take place at the Johns Hopkins Bayview Medical Center and the Johns Hopkins Hospital in Baltimore, MD. Volunteers will be paid for completion of all study procedures. Travel expenses will be covered. Please call 410-550-2588 or 410-550-5295 or email johnshopkins.lab@gmail.com for more information. Principal Investigator: Una D. McCann (IRB Number: NA_00031313)

TOURETTE'S DISORDER

Effects of Tic Suppression Study
Children and adolescents (ages 10-17) with either Tourette’s Disorder or Chronic Tic Disorders who are interested in helping researchers understand the effects of prolonged suppression of tics may be eligible for this study. A growing body of evidence supports behavioral treatments as effective interventions for reducing tic symptoms. Currently very little is known about the effects of prolonged tic suppression, an active treatment component. Information collected in this research study will allow researchers to better understand the effects of prolonged tic suppression and will be used to develop behavioral treatments for tic disorders that are increasingly effective and acceptable to patients. Potential participants will initially complete a screen via telephone. Those who appear to be eligible for the study will be asked to visit the clinic on one occasion for approximately four hours. During the appointment participants and their parents will be asked to complete questionnaires, diagnostic interviews as well as a video-taped observation of tic symptoms before beginning a tic suppression task. If you are interested, please contact Dr. Specht at 410-614-4236 or by email: mspecht1@jhmi.edu. Principal Investigator: Matt W. Specht, Ph.D. Co-Investigator: John T. Walkup, M.D. (IRB Protocol #00016155) Click here for PDF Brochure

Genetic Linkage Study of Gilles de la Tourette Syndrome
Children or adults diagnosed with Tourette’s Syndrome who are 7 years of age and older are eligible to participate. Both parents and the individual diagnosed with TS have to be available for a blood draw and a direct interview. What to expect from participating: 1) Complete an interview and self report; 2) Give a small amount of blood; 3) Psychiatric evaluation of the affected individual. Marco Grados, M.D., M.P.H. is the principal investigator. Call 410-287-2292. (IRB Protocol #NA_00001407)

Neural Circuitry in Tourette's Syndrome - Children ages 8 - 18
Dr. Stewart Mostofsky and colleagues at the Kennedy Krieger Institute and the Johns Hopkins Hospital are recruiting children between the ages of 8 and 18 years to participate in a study investigating neural circuitry in Tourette syndrome.  This study is examining patterns of brain activation involved in tic generation, motor response, and inhibition.  We are looking for boys and girls with Tourette syndrome (with and without ADHD) as well as children who do not have ADHD or Tourette syndrome to participate as “comparison subjects”.  The study involves paper and pencil tasks and computer activities.. None of these tests are harmful or painful.  The study involves one day of testing.  Participants will receive $50.00 . While there are no direct medical benefits parents will receive a report summarizing the IQ testing administered to their child..  All testing is done free of charge. For more information about this study, please contact Lindsay Koenig at (443) 923-9254 or by email at KoenigL@kennedykrieger.org. Stewart H. Mostofsky, M.D. is the Principal Investigator. Click here  for a PDF flyer. (IRB Protocol # 03-11-12-03)
 

NOTICE TO RESEARCHERS: If you are faculty in the Department of Psychiatry and Behavioral Sciences and you wish to post a recruitment ad on this page, please contact Donna Mennitto at dmennit2@jhmi.edu. You will need to send the IRB-approved recruitment language in paragraph form with a title of the study, the PI, contact information and the IRB Protocol Number. If you wish to make a flyer available to the public, send it in PDF or Word document form. You are responsible for IRB approval of the ad. Please be sure to contact us to remove the ad from this page when recruitment is complete. Thank you.

 

 

       

 

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