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Research Volunteers Needed

National Institute of Mental Health
A Participant's Guide to Mental Health Clinical Research
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NOTICE TO RESEARCHERS

ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)

>ADHD in Adolescents with Substance Use Disorder
We are looking for adolescents ages 13-18 that meet criteria for both ADHD and substance use disorder (SUD) and are interested in participating in a research study. Potential participants will receive free Cognitive Behavioral Therapy for 16 weeks focused on Substance Use, and at the same time, will be randomly assigned to OROS-Methylphenidate (also known as Concerta) or placebo. Participants will be seen for a preliminary assessment to ensure the study is a good fit for them, and those that are appropriate, will continue with weekly visits for 16 weeks, followed by a month check-in visit at week 20. All assessments and treatments will be provided at no cost and there will be cash reimbursement for participation. Geetha Subramaniam, M.D. is the site principal investigator. Call 410-233-1400 ext 172/177 for further details. Click here for a PDF flyer. (JHU-IRB Protocol # NA_00002443)

> Children With and Without ADHD - 4th - 8th Grade
Reasearcher at the Kennedy Krieger Institute are recruiting children in grades four through eight to participate in a study of processing speed and memory. We are recruiting children to participate in a study to learn if there are differences in the way children with and without ADHD learn to read and remember what they have read. The study involves paper and pencil tasks, computer activities, Magnetic Resonance Imaging (MRI) and electrophysiological (EEG) studies of the brain. Parents will also complete questionnaires, rating scales, and a structured interview. None of these tests are harmful or painful. The study involves two to three days of assessment, about three to five hours each day. Participants will receive $50.00 and a picture of their brain. Parents will receive a report of the tests administered to their child. All testing is done free of charge. There are no medical benefits or significant risks to participating. E. Mark Mahone, Ph.D. is the principal investigator. For more information about this study, please contact Matthew Ryan at (443) 923-9272 or by email ryanm@kennedykrieger.org. Click here for a flyer. (IRB Protocol #NA_00001350)

> Children With and Without ADHD - Ages 8 -12
Dr. Stewart Mostofsky and colleagues at the Kennedy Krieger Institute are recruiting children between the ages of 8 and 12 years to participate in a research study of attention, response planning and inhibitory control. This study is examining the brain basis of ADHD in children. We are looking for boys and girls with ADHD as well as children who do not have ADHD to participate as “comparison subjects”. The study involves paper and pencil tasks, computer activities and a Magnetic Resonance Imaging (MRI) of the brain. None of these tests are harmful or painful. There are no direct medical benefits from taking part in the study. The study involves two days of testing and MRI. Participants will receive $50.00 and a picture of their brain. Parents will receive a report of the tests administered to their child. All testing is done free of charge. For more information about this study, please contact Jessica O’Brien at (443) 923-9254 or by email (obrienj@kennedykrieger.org). Click here for a flyer. (IRB protocol #02-11-25-01)

> Children With and Without ADHD - Ages 9-11.5
Dr. Mark Mahone and colleagues at the Kennedy Krieger Institute are recruiting children between the ages of 9 and 11½ years to participate in a research study of attention, response planning and inhibitory control. This study is examining the brain basis of ADHD in girls. We are looking for boys and girls with ADHD as well as children who do not have ADHD to participate as “comparison subjects”. The study involves paper and pencil tasks, computer activities and a Magnetic Resonance Imaging (MRI) of the brain. None of these tests are harmful or painful. The study involves two days of testing and MRI. Participants will receive $50.00 and a picture of their brain. Parents will receive a report of the tests administered to their child. All testing is done free of charge. E. Mark Mahone, Ph.D. is the principal investigator. For more information about this study, please contact Jessica O’Brien at (443) 923-9254 or by email (obrienj@kennedykrieger.org). Click here for a flyer. (IRB protocol #02-11-05-05)

ANXIETY DISORDERS

> Child Anxiety Prevention Study (CAPS)
We are conducting a research study at Johns Hopkins that evaluates the effectiveness of a prevention program for child anxiety. Because children of anxious parents are more likely to develop problems with anxiety, we are inviting parents who either have an anxiety disorder or think they have serious problems with anxiety to participate in a research study along with their children ages 7 to 12. As part of this study, you and your child will receive a free initial comprehensive evaluation. There is no cost, and families may earn up to $75 for participation. The prevention program may help to: improve parenting skills, develop ways to cope with anxiety for all family members, improve family knowledge and communication about anxiety, and prevent child anxiety problems. If interested in learning more about this project, contact: Candice Festa (443-287-4349) or Scott Woodruff (410-502-6077). You can also email: CAPS@jhmi.edu. Golda S. Ginsburg, Ph.D. is the principal investigator. Click here for a PDF flyer. (JHMIRB Protocol #NA_00019402)

> Baltimore City Anxiety Treatment School Study (BCATSS)
We are conducting a study in three Baltimore City Schools that compares two ways to help kids who worry a lot: Typical School-Based Counseling (which is the talk therapy that is used in schools now) and Cognitive Behavioral Therapy (CBT: a special kind of talk therapy that has been shown to reduce anxiety in children in university-based research studies). Children and adolescents between the ages of 7 and 17, who have a lot of anxiety, and who attend school at Dr. Rayner Browne, Commodore John Rodgers, or Hazelwood Elementary/Middle are eligible. Benefits of participating in this study are that your child's anxiety may improve and you may receive up to $75 in gift cards for being part of the study. If interested, please contact Kim Becker, Ph.D. at 410-614-3317. Golda S. Ginsburg, Ph.D. is the principal investigator. Click here for a PDF brochure. (JHMIRB Protocol #NA_00005456)

> Children With and Without Anxiety Disorders - Ages 8-12
We are conducting a research study that examines differences in brain function between children with anxiety disorders and children without anxiety disorders. The study involves a psychological assessment and a Magnetic Resonance Imaging (MRI) scan of the brain. Testing takes about six hours and can be done in two to three visits. There are no direct benefits of the study. There are no major risks associated with this study. All testing is free. The information will help us understand what causes anxiety in children. Children will receive $100.00 for completing the study, a small gift, a free psychological evaluation, plus a picture of their brain! Parking at the Institute is free. For more information please contact Roma Vasa, M.D. at 443-923-2643 or vasa@kennedykrieger.org. Click here for a PDF flyer. (KKI Protocol Number: NA_00003215)

Emotional Attention and Memory in Children with Anxiety Disorders
If you have a child between the ages of 8 and 12 who is scared or worried a lot, you and your child may be eligible to participate in our research study. The study involves a single testing session that takes approximately 2 ½ hours. The session includes a psychological assessment and a short computer test. There are no direct benefits of the study. All testing is free. The information will help us understand what causes anxiety in children. There are no major risks associated with this study. Children will receive $50.00 for completing the study, free psychological testing, and free parking. For more information please contact the Principal Investigator, Roma Vasa, M.D., at (443) 923-2643 or vasa@kennedykrieger.org. Please click here to download a PDF flyrer. (KKI Protocol Number: NA_00014313)

> Psilocybin and Cancer: A Scientific Study of States of Consciousness
We are seeking cancer patients with anxious or depressed mood to participate in a scientific study of state of consciousness brought about by the entheogen psilocybin, a psychoactive substance found in mushrooms used as a sacrament in some cultures, given in a comfortable, supportive setting. Questionnaires and interviews will be used to assess the effects of the substance on consciousness, mood, and behavior. Volunteers enrolled in the study will receive careful preparation and two sessions in which they will receive psilocybin. Structured guidance will be provided during the session and afterwards to facilitate integration of the experiences. Volunteers must be 21 to 70 years old, have no personal history of severe psychiatric illness or recent history of alcoholism or drug abuse, have someone willing to pick them up and drive them home at the end of the two psilocybin sessions (around 5:00 PM), and must live within travel distance of the Johns Hopkins Bayview Medical Center in Baltimore. If you would like to discuss the possibility of volunteering, please call 410-550-5990 and ask for Mary, the study's research coordinator. Confidentiality will be maintained for all applicants and participants. Roland R. Griffiths, Ph.D. is the principal investigator. More information available at www.bpru.org/cancer. Click here for PDF flyer. (IRB Protocol #NA_00001390)

AUTISM

> Motor Skill Learning in Autism - Ages 8-12
Dr. Stewart H. Mostofsky and Dr. Melissa Goldberg of the Kennedy Krieger Institute and Johns Hopkins School of Medicine are recruiting children with high-functioning autism between 8 and 12 years of age to participate in a study of attention, learning, memory, and motor skills. The study involves paper and pencil tasks, computer activities and an MRI of the brain. None of the tests are harmful or painful and are done free of charge. There are no direct medical benefits for participating in the study. The duration of the study is two to three days. Participants will receive a $50 check and a picture of their brain. Parents will receive a report summarizing the IQ testing administered to their child. All testing is done free of charge. For more information about this study, please contact Jessica O’Brien at (443) 923-9254. Stewart H. Mostofsky, Ph.D. is the Principal Investigator. Click here for a PDF flyer. (IRB Protocol # 03-05-27-10)

> Volunteers Aged 4-17
Researchers at Kennedy Krieger are looking for children with mental retardation or autism to participate in research that studies how children with disabilities perform differently on a computerized task. We are recruiting children who have been diagnosed with mild to severe mental retardation and children who have been diagnosed with autism. There are no medical benefits or significant risks for joining the study. Children will be asked to participate in 10 to 15 two-hour visits and will receive $20 for each visit plus an additional $20 bonus if the study is completed. For more information, please contact: Lisa Toole, M.A., BCBA at 443-923-9535. Principal Investigator: Louis Hagopian, Ph.D., Kennedy Krieger Institute. Sponsored by: National Institute of Child Health and Human Development and Neurobehavioral Research Unit of the Johns Hopkins General Clinical Research Center. Click here for PDF flyer.(RPN#: 03-07-28-10)

BIPOLAR DISORDER

> Bipolar I Depression Research Study
Have you been diagnosed with Bipolar I Disorder? Are you currently depressed? If so, you may qualify for an 8 week research study for the treatment of Bipolar I Disorder. Qualified participants will receive study medication or a placebo, laboratory tests, and compensation for their participation. For more information, please call (410) 502-2586 or email moodtrials@jhmi.edu. Jennifer Payne, MD is the principal investigator. (IRB Protocol #00026576)

>Bipolar Disorder Research Study
Have you been diagnosed with bipolar disorder? Do you sometimes have trouble concentrating? If so, you may qualify for a 16 - 18 week research
study for treatment of bipolar disorder. We are looking for adults between the ages of 18 and 65 who are currently in treatment with an outpatient psychiatrist. Volunteers will receive study medication, laboratory tests and will be compensated for their participation. For more information, please call (410) 502-2586 or email moodtrials@jhmi.edu. Jennifer Payne, MD. is the principal investigator. (IRB Protocol #NA_0009034)

>Mood Disorders and Pregnancy Study
The Johns Hopkins Women's Mood Disorders Center is currently seeking women who have a history of depression or bipolar disorder to participate in a naturalistic study that would follow them during pregnancy and the postpartum period. Participants may enter during any trimester and would have visits during each trimester and 1 week, 1 month, and 3 months postpartum. Volunteers will be compensated for their participation. For more information, please call 410-502-2586 or email moodtrials@jhmi.edu. Jennifer Payne, MD is the principal investigator. (IRB Protocol #NA_00008149)

> Child Gaining Weight on Medication? Dr. Mark Riddle and colleagues in the Johns Hopkins Division of Child and Adolescent Psychiatry are conducting a treatment research study funded by the National Institute of Mental Health. The goal of the study is to find improved treatments for youth who have a have gained weight while taking antipsychotic medication. We are currently seeking children ages 8-17 who are taking olanzapine (Zyprexa®), quetiapine (Seroquel®), risperidone (Risperdal®), aripiprazole (Abilify®), or ziprasidone (Geodone®) and have gained a significant amount of weight in the past year while taking one of these medications. Consenting children who meet eligibility criteria will receive a medical and psychiatric evaluation and will be assigned to one of three groups: 1) stay on current medication, 2) switch from current medication to aripiprazole (Abilify®) or molindone (Moban®), 3) stay on current medication and add metformin (Glucophage®). Participants receive study-related evaluations and treatment at no cost.
For further information call 410-614-5174 or email impact@jhu.edu . Principle Investigator:Mark Riddle, MD (JHU IRB #00017204) Click here for PDF brochure.

> Bipolar Depression Research Study
Have you been diagnosed with bipolar disorder? Do you feel that medications have not helped your depression? If so, you may qualify for an 8-12 week research study for treatment of bipolar depression. We are looking for adults between the ages of 18 and 75, who are depressed, currently in treatment with an outpatient psychiatrist and are taking a mood stabilizer. Volunteers will receive study medication, laboratory tests and will be compensated for their participation. For more information, please call 410-502-2334. Jennifer Payne, MD. is the principal investigator. (IRB Protocol #04-04-23-10)

BULIMIA NERVOSA

> Bulimia Research Study
The Johns Hopkins Eating Disorders Program is seeking women 18-40 years old with bulimia nervosa interested in a research study funded by the Klarman Family Foundation. The study includes a health assessment, blood testing and pictures of the brain taken using a medical scanner. Eligible women will be paid up to $400 for their participation and will be offered 6 weeks of outpatient treatment. Please call (410) 955-3863 for more information.Principal Investigator: Angela Guarda, M.D. (IRB Approval # NA_00018499)

DEPRESSION

>Mood Disorders and Pregnancy Study
The Johns Hopkins Women's Mood Disorders Center is currently seeking women who have a history of depression or bipolar disorder to participate in a naturalistic study that would follow them during pregnancy and the postpartum period. Participants may enter during any trimester and would have visits during each trimester and 1 week, 1 month, and 3 months postpartum. Volunteers will be compensated for their participation. For more information, please call 410-502-2586 or email moodtrials@jhmi.edu. Jennifer Payne, MD.is the principal investigator. (IRB Protocol #NA_00008149)

> Geriatric Depression Study
Are you over 60 and feeling depressed? Symptoms of depression in older adults are common yet often go undetected. Symptoms could include feelings of sadness or hopelessness, loss of energy, inability to enjoy pleasurable activities, changes in appetite or sleeping patterns, or poor concentration/memory. If you are feeling depressed, not taking antidepressant medication and in good physical health you may be eligible to participate in a research study involving treatment. Qualified people will participate at no cost to them and will be compensated for their time and transportation. For more information about the research study, please call us at 410-550-9052 or email us at cworkma3@jhmi.edu. Click here for a PDF flyer. Principal Investigator: Gwenn Smith, PhD (IRB Protocol No: NA_00021615)

HEALTHY VOLUNTEERS

> PET Scans of Healthy Volunteers Over 60 Years of Age
We are conducting brain imaging research using a technique called Positron Emission Tomography, or PET for short, to take pictures of the brain. If you are in good health and aren’t taking medications that affect the brain, you may qualify for participation. Qualified people will participate at no cost to them. Compensation for time and transportation will be provided. For more information, please call: (410) 550-9052. Principal Investigator: Gwenn Smith, PhD (IRB Protocol No: NA_00021615). Click here for a copy of our flyer.

> Emotional Attention and Memory in Healthy Children
We are searching for healthy, typically developing children ages 7 to 17 and their parents to take part in a research study at the Kennedy Kreiger Institute/Johns Hopkins Hospital. Participation involves a psychological evaluation with the parent and child, a brief measurement of the child's IQ, and a computer test to see how children react to different faces and words. The study requires one two and half hour visit. There are no direct benefits to the child for participating in this study. There are no significant medical risks associated with the study. Roma Vasa, M.D. is the principal investigator. Call 443-923-2643. Click here for a PDF flyer. (IRB Protocol # NA_00004616)

> Healthy Individuals for Study of Mental Illness
The goal of this study is to gain a better understanding of schizophrenia and other forms of mental illness. We are seeking to compare individuals without schizophrenia to individuals who do have schizophrenia. We are looking for individuals who DO NOT have schizophrenia. To be eligible for the study, participants must be willing to have a blood sample drawn, be 14 years or older, have no history of stroke, brain tumor or serious brain injury, not consume alcohol or street drugs daily and speak English. Participation in the study involves release of medical records, a clinical interview and a blood sample. Participants will be paid $20 for their time. If you or someone you know might be interested in the study or have questions about the study, please call Nadine Yoritomo, R.N. at 410-502-5887 or email schizophrenia@jhmi.edu. Principal Investigator: Russell Margolis, M.D. (RPN # NA_00009162)

> Children With and Without ADHD - 4th - 8th Grades
Reasearcher at the Kennedy Krieger Institute are recruiting children in grades four through eight to participate in a study of processing speed and memory. We are recruiting children to participate in a study to learn if there are differences in the way children with and without ADHD learn to read and remember what they have read. The study involves paper and pencil tasks, computer activities, Magnetic Resonance Imaging (MRI) and electrophysiological (EEG) studies of the brain. Parents will also complete questionnaires, rating scales, and a structured interview. None of these tests are harmful or painful. The study involves two to three days of assessment, about three to five hours each day. Participants will receive $50.00 and a picture of their brain. Parents will receive a report of the tests administered to their child. All testing is done free of charge. There are no medical benefits or significant risks to participating. E. Mark Mahone, Ph.D. is the principal investigator. For more information about this study, please contact Matthew Ryan at (443) 923-9272 or by email ryanm@kennedykrieger.org. Click here for flyer. (IRB Protocol #NA_00001350)

> Children With and Without ADHD - Ages 9-11.5
Dr. Mark Mahone and colleagues at the Kennedy Krieger Institute are recruiting children between the ages of 9 and 11½ years to participate in a research study of attention, response planning and inhibitory control. This study is examining the brain basis of ADHD in girls. We are looking for boys and girls with ADHD as well as children who do not have ADHD to participate as “comparison subjects”. The study involves paper and pencil tasks, computer activities and a Magnetic Resonance Imaging (MRI) of the brain. None of these tests are harmful or painful. The study involves two days of testing and MRI. Participants will receive $50.00 and a picture of their brain. Parents will receive a report of the tests administered to their child. All testing is done free of charge. For more information about this study, please contact Jessica O’Brien at (443) 923-9254 or by email ( obrienj@kennedykrieger.org). Click here for a flyer. (IRB protocol #02-11-05-05)

> Neural Circuitry in Tourette's Syndrome - Children ages 8 - 18
Dr. Stewart Mostofsky and colleagues at the Kennedy Krieger Institute and the Johns Hopkins Hospital are recruiting children between the ages of 8 and 18 years to participate in a study investigating neural circuitry in Tourette syndrome. This study is examining patterns of brain activation involved in tic generation, motor response, and inhibition. We are looking for boys and girls with Tourette syndrome (with and without ADHD) as well as children who do not have ADHD or Tourette syndrome to participate as “comparison subjects”. The study involves paper and pencil tasks, computer activities and a Magnetic Resonance Imaging (MRI) of the brain. None of these tests are harmful or painful. The study involves two days of testing and MRI. Participants will receive $50.00 and a picture of their brain. While there are no direct medical benefits parents will receive a report of the tests administered to their child. All testing is done free of charge. For more information about this study, please contact Jessica O’Brien at (443) 923-9254 or by email at OBrienJ@kennedykrieger.org. Stewart H. Mostofsky, M.D. is the Principal Investigator. Click here for a PDF flyer. (IRB Protocol # 03-11-12-03)

HUNTINGTON'S DISEASE

> Clinical Trial (Phase 2) of Dimebon
The Huntington Study Group (HSG) is conducting a study of the research medication Dimebon in persons 18 years of age or older who have mild to moderate Huntington’s disease (HD). The DIMOND trial is designed to determine safe and tolerable doses of Dimebon and also to determine the effect of Dimebon on cognitive (thinking) and motor (movement) signs and overall functioning of subjects with HD. Approximately 15 research centers in the United States (of which Johns Hopkins is one) and in the United Kingdom will enroll up to 90 research subjects and will last about 3 months. The study will enroll research subjects with early to moderate signs of HD who are independently ambulatory (walking) and self-sufficient in activities of daily living, such as eating, dressing, and bathing. Enrollment will begin in the Summer of 2007. The study is sponsored by Medivation, Inc. If you are interested in participating, call the Huntington Study Group toll free 1-800-487-7671. Click here for the Baltimore Huntington's Disease Center. (IRB Protocol # NA_00012285)

MEMORY DISORDERS

> More Forgetful Than Others Your Age?
Researchers at the Johns Hopkins University School of Medicine are looking for volunteers over age 55 with mild memory problems to take part in a study of planning and problem-solving. Participants will take several hours of interesting mental tests on one day, and then again two years later. A family member or close friend who knows them well will be interviewed and must accompany them to research visits. Participants will be paid $20 per completed visit. Jason Brandt, Ph.D. is the principal investigator. (IRB #03-07-08-06) For more information, contact Ms. Eleanor Neijstrom at (410) 955-1647.

> Caring for Memory Problems at Home (MIND at Home Project)
We are currently looking for research volunteers 70 years of age or older with memory disorders to take part in an innovative 1½ year intervention research study. The goal of the study is to find out if providing assistance in obtaining appropriate care for older adults with memory problems will help them remain at home longer, as well as other possible benefits. Participants are visited in their homes several times over the course of 18 months by a specially trained team fromJohns Hopkins. The purpose of these visits is to find out about how their memory is doing, how they have been doing recently, and if they have had any changes in their condition. Eligible persons must also have someone who knows them well to agree to take part as their study partner. Some participants will be selected at random to receive assistance from a specially trained dementia care coordinator, at no cost to them. All participants are compensated for their time and receive a free written evaluation. If you or someone you know is 70 years and older, complains of or has memory problems, lives at home in North/Northwest Baltimore (zip codes: 21022, 21030, 21031, 21065, 21093, 21094, 21117, 21133, 21136, 21139, 21153, 21204, 21207, 21208, 21209, 21210, 21211, 21212, 21215, 21234, 21235, 21239, 21241, 21244, 21252, 21284, 21285, 21286), please contact Chris Lyman, study coordinator at 410-502-0773 or clyman3@jhmi.edu. Quincy M. Samus, PhD is the Principal Investigator of the study (IRB Protocol No: NA_00012829). Click here for a MIND at Home flyer.

OBSESSIVE-COMPULSIVE DISORDERS

> Genetics of Obsessive-Compulsive Disorder
Families who are within a 100 mile radius of Baltimore, MD and who have a child with Obsessive-Compulsive Disorder (OCD) are invited to help scientists learn more about the causes of OCD. Participants will be given a confidential interview about their medical and psychiatric history and will be asked to provide a small sample of blood. Participants need not travel. Confidentiality of all information is assured. Marco Grados, M.D., M.P.H.is the principal investigator. Call 443-287-2292. Click here for a PDF brochure. (IRB Protocol # 02-10-17-09)

> Children and Adolescents: Psychosocial Study
We’re interested in studying how children and adolescents ages 6 through 17, either with obsessive-compulsive symptoms or without them, function within their families. The study occurs in the home; no hospital or school visits are necessary. We conduct a phone interview with parents to discuss a child’s behavior and daily functioning as well as the parent-child relationship. Paper-and-pencil questionnaires are given on various aspects of family functioning. Children or adolescents also participate in a phone interview regarding behavior and daily functioning. They, too, fill out questionnaires on the parent-child relationship and on personality. When participation is finished, children are given a $15 gift certificate to a book store. Marco Grados, M.D., M.P.H, is principal investigator. Call 443-287-2291 or email mjgrados@jhmi.edu. (IRB Protocol # 02-10-29-01. Approved 3/20/07)

> Cytokine levels and genes in Obsessive-Compulsive Disorder: A Longitudinal Study
This study aims to understand how OCD manifests in children over one-year, using monthly follow-up assessments. Some children are known to have dramatic exacerbations, others will have a more stable course of symptoms. Both groups will be compared for immune markers (cytokines). It is hypothesized that children with dramatic exacerbations have an immune difference compared to other children with OCD, measured by cytokine levels in blood. Marco Grados, M.D., M.P.H is the prinicipal investigator. Call 443-287-2291 or email mjgrados@jhmi.edu. (IRB Protocol # NA_00001439. Approved 01/11/2007)

> Families with Obsessive-Compulsive Disorder
A team of researchers is studying the occurrence of OCD in families. We are now investigating genetic factors which may increase the susceptibility to OCD. Recent advances in molecular biology and statistical genetics make it possible to identify and describe specific genes that may cause complex diseases such as OCD. We are seeking families with OCD to help conduct these studies. Individuals with OCD are invited to participate in the study. Participants are given a confidential interview about their medical history and will be asked to provide a small sample of blood. Participants do NOT need to travel. Confidentiality of all information is assured. Families may be referred by a clinician or they may contact us directly. Gerald Nestadt, M.D., M.P.H. is the principal investigator. Call 410-614-4942. (Collect calls accepted.) or email jacks@jhmi.edu. (IRB Protocol # 91-11-20-02)

PARKINSON'S DISEASE

> Database for Future Research Studies
Investigators seek volunteers with Parkinson's disease and volunteers without neurological disease over age 21 who agree to be contacted for future research studies. This does not obligate you to participate in any study you many be contacted about. Please call Melissa Gerstenhaber, R.N. at (410) 614-1242. Laura Marsh, M.D. is the principal investigator. (IRB Protocol # 98-05-08-06). Click here for a PDF flyer.

> Depression in PD Clinical Research Trial
Investigators are seeking volunteers with Parkinson's disease, over 30 years old, for participation in a study funded by NIH/NINDS. If you feel sad, withdrawn, have appetite and/or sleep changes, concentration or lack motivation you may qualify for this study. The study offers evaluation and study medication.Laura Marsh, M.D. is the Site Principal Investigator. If interested, call Melissa Gerstenhaber, R.N. at 410-614-1242. (IRB Protocol # 20040690) Click here for a PDF flyer.

> Early Onset PD - Consortium On Risk for Early-onset (CORE) PD Study
Do you have Parkinson’s disease (PD)? Did you experience onset of motor signs at or before age 50? Did you receive your diagnosis of PD from a neurologist? If you answered yes to all three questions, you may be eligible to participate in a research study to investigate genetic and environmental risk factors that increase susceptibility to the development of PD. Participation in this research study involves a blood draw, questionnaires collecting information on family and medical history, and a neurological exam. Principal Investigator is Laura Marsh, M.D. (IRB Protocol # NA_00002271) If you think you are eligible and are interested in learning more information about the study please contact Melissa Gerstenhaber, R.N. at 410-614-1242. Click here for a PDF flyer.

> Brain Donation Registry - PD and Healthy Brains
Individuals with Parkinson’s disease or related movement disorders (such as Lewy Body Disease) are being recruited to participate in a brain donation program funded by the NIH through the Morris K. Udall Parkinson's Disease Research Center of Excellence at Johns Hopkins. Individuals with no history of a brain disorder may also participate as a control. Registration in the brain donation program enables the individual to donate their brain, at the time of their death, for scientific research on the underlying mechanisms of Parkinson's disease. The program, including the actual brain donation program, is free for participants. Families also receive a diagnostic report. Principal Investigator is Laura Marsh, M.D. (IRB Protocol # 98-05-08-06) Please contact Melissa Gerstenhaber, R.N., M.S.N. at 410-614-1242. Click here for a PDF flyer.

> DNA Repository for PD
Blood samples are need from participants with Parkinson’s Disease. The DNA samples will be collected, stored, and distributed to investigators. You must be 18 years of age or older. Principal Investigator is Laura Marsh, M.D.. (IRB# NA_00001079) Please call study coordinator Melissa Gerstenhaber R.N.C, M.S.N. at (410) 614-1242. Click here for PDF flyer.

SCHIZOPHRENIA

> Epidemiological Study of Schizophrenia and Schizoaffective Disorder
Jewish individuals are needed to participate in a study to understand the biological basis of schizophrenia and schizoaffective disorder. Participation involves a confidential interview and a blood sample. We come to you. Compensation is $100. Ann E. Pulver, Ph.D., is principal investigator. Call 1-888-289-4095 or e-mail familystudy@jhmi.edu (IRB Protocol # 84-05-31-04)

> Schizophrenia Study
The goal of this study is to gain a better understanding of schizophrenia. To be eligible for the study, participants must have schizophrenia, schizoaffective or related disorders, be willing to have a blood sample drawn, be 14 years or older, have no history of stroke, brain tumor or serious brain injury, not consume alcohol or street drugs daily and speak English. Participation in the study involves release of medical records, a clinical interview and blood sample. Participants will be paid $20 for their time. If you or someone you know might be interested in the study or have questions about the study, please call Nadine Yoritomo, R.N. at 410-502-5887 or email schizophrenia@jhmi.edu. Principal Investigator: Russell Margolis, M.D. (RPN # NA_00009162)

SLEEP DISORDERS

> Insomnia and Osteoarthritis Study
Volunteers are needed for a research study conducted at Johns Hopkins to evaluate a new sleeping medication in patients with osteoarthritis of the knee. To participate, you must be: between 18 & 64 years old and have had trouble sleeping for at least 6 months. Examinations, parking, and study pills are provided at no cost. Compensation up to $150. Call 410.614.3396 and/or visit the website at www. sleeplessinbaltimore.com. Principal Investigator: Michael T. Smith, Ph.D. (Protocol NA_00001703)

> Sleep In Osteoarthritis Program
Volunteers are needed for a research study conducted at Johns Hopkins to study SLEEP in patients with osteoarthritis of the knee. To participate, you must be 50 years or older. Both good and poor sleepers are needed. Parking, and tests are provided at no cost. Compensation is provided. Call 410.614.3396 and/or visit the website at www. sleeplessinbaltimore.com. Principal Investigator: Michael T. Smith, Ph.D. (Protocol NA_000118021)

SMITH-LEMLI-OPITZ SYNDROME

> Investigation of Simvastatin Therapy in Smith-Lemli-Opitz Syndrome
Children with Smith-Lemli-Opitz Syndrome (SLOS) are needed for a research study to see if simvastatin helps with behavior and the cholesterol balance in the body. The Kennedy Kreiger Institute (KKI) in Baltimore, Maryland is conducting this study in partnership with a study at the National Institutes of Health Clinical Center in Bethesda, Maryland. This study is to see if simvastin is helpful and safe for use in people with SLOS. Over 26 months, participant will visit the KKI and NIH fives times at each site. Elaine Tierney, M.D. is the prinicipal investigator. For more information, call 301-594-2005. Click here for a study flyer. (IRB Protocol # 03-11-20-08)

SUBSTANCE ABUSE/ADDICTIONS

> ADHD in Adolescents with Substance Use Disorder
We are looking for adolescents ages 13-18 that meet criteria for both ADHD and substance use disorder (SUD) and are interested in participating in a research study. Potential participants will receive free Cognitive Behavioral Therapy for 16 weeks focused on Substance Use, and at the same time, will be randomly assigned to OROS-Methylphenidate (also known as Concerta) or placebo. Participants will be seen for a preliminary assessment to ensure the study is a good fit for them, and those that are appropriate, will continue with weekly visits for 16 weeks, followed by a month check-in visit at week 20. All assessments and treatments will be provided at no cost and there will be cash reimbursement for participation. Geetha Subramaniam, M.D. is the site principal investigator. Call 410-233-1400 ext 172/177 for further details. Click here for a PDF flyer. (JHU-IRB Protocol # NA_00002443)

> Investigational Treatment for Addiction
Are you 18-65 years old, currently addicted to heroin or prescription pain relievers and seeking treatment? Researchers at Johns Hopkins Bayview Medical Center are conducting an outpatient research study to test an investigational medication for opiate addiction. If you qualify, you will receive study-related care at no cost and you will be compensated. Compensation of up to $1,950. George Bigelow, Ph.D. is the principal investigator. Call 410-550-0007 for a phone interview. Click here for a PDF flyer. (Protocol # NA00008622)

TOURETTE'S DISORDER

> Effects of Tic Suppression Study
Children and adolescents (ages 10-17) with either Tourette’s Disorder or Chronic Tic Disorders who are interested in helping researchers understand the effects of prolonged suppression of tics may be eligible for this study. A growing body of evidence supports behavioral treatments as effective interventions for reducing tic symptoms. Currently very little is known about the effects of prolonged tic suppression, an active treatment component. Information collected in this research study will allow researchers to better understand the effects of prolonged tic suppression and will be used to develop behavioral treatments for tic disorders that are increasingly effective and acceptable to patients. Potential participants will initially complete a screen via telephone. Those who appear to be eligible for the study will be asked to visit the clinic on one occasion for approximately four hours. During the appointment participants and their parents will be asked to complete questionnaires, diagnostic interviews as well as a video-taped observation of tic symptoms before beginning a tic suppression task. If you are interested, please contact Dr. Specht at 410-614-4236 or by email: mspecht1@jhmi.edu. Principal Investigator: Matt W. Specht, Ph.D. Co-Investigator: John T. Walkup, M.D. (IRB Protocol #00016155)

> Genetic Linkage Study of Gilles de la Tourette Syndrome
Children or adults diagnosed with Tourette’s Syndrome who are 7 years of age and older are eligible to participate. Both parents and the individual diagnosed with TS have to be available for a blood draw and a direct interview. What to expect from participating: 1) Complete an interview and self report; 2) Give a small amount of blood; 3) Psychiatric evaluation of the affected individual. Marco Grados, M.D., M.P.H. is the prinicipal investigator. Call 410-287-2292. (IRB Protocol #NA_00001407)

NOTICE TO RESEARCHERS: If you are faculty in the Department of Psychiatry and Behavioral Sciences and you wish to post a recruitment ad on this page, please contact Donna Mennitto at dmennit2@jhmi.edu. You will need to send the IRB-approved recruitment language in paragraph form with a title of the study, the PI, contact information and the IRB Protocol Number. If you wish to make a flyer available to the public, send it in PDF or Word document form. You are responsible for IRB approval of the ad. Please be sure to contact us to remove the ad from this page when recruitment is complete. Thank you.

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