 | Associate Professor Main Office Address Meyer 4-119 E-mail: jpotash@jhmi.edu Administrative Assistant Kelly Weggel |
Education
1984 | B.A. | Yale University |
1989 | M.P.H. | Johns Hopkins School of Public Health |
1993 | M.D. | Johns Hopkins School of Medicine |
1993-1994 | Medicine Internship | Johns Hopkins Bayview Medical Center |
1995-1998 | Psychiatry Residency | Johns Hopkins Hospital |
Professional Interests
My focus is on mood disorders. I see patients with depression and with bipolar disorder in several settings, including a mood disorders consultation clinic and an inpatient mood disorders unit. My research centers on the genetics of mood disorders. I am particularly interested in the psychotic forms of depression and bipolar disorder, and in the hypothesis that genes predisposing to these forms of illness may also predispose to schizophrenia. Our lab is also studying the genetics of recurrent early-onset depression in the context of a multi-site study. The third research area we are focused on involves the possible role of epigenetics in mood disorder susceptibility. This work is being conducted in collaboration with Dr. Andrew P. Feinberg in the department of medicine.
Click here for Mood Program Genetics Research
Click here for Bioformoodics: Tools for Gene Discovery in Mood Disorders
Click here for The Epigenetics Center
Click here and here for Hopkins Brain Wise Newsletter articles about Dr. Potash's work
Selected Publications
Potash JB, Willour VL, Chiu Y-F, Simpson SG, MacKinnon DF, Pearlson GD, DePaulo Jr JR, and McInnis MG. The familial aggregation of psychotic symptoms in bipolar disorder. Am J Psychiatry 158:1258-64, 2001.
Potash JB, Zandi PP, Willour VL, Lan TH, Avramopoulos D, Huo Y, Shugart YY, MacKinnon DF, Simpson SG, McMahon FJ, DePaulo Jr JR, and McInnis MG. Suggestive evidence of linkage to 13q31 and 22q12 in families with psychotic bipolar disorder. Am J Psychiatry 160:680-686, 2003.
Ladd-Acosta C, Pevsner J, Sabunciyan S, Yolken RH, Dinkins T, Callinan PA, Fan JB, Potash JB*, and Feinberg AP. DNA methylation signatures within the human brain. Am J Hum Genet 81:1304-15, 2008. *corresponding and co-senior author
Zandi PP, Belmonte PL, Willour VL, Goes FS, Badner JA, Simpson SG, Bipolar Disorder Phenome Group, NIMH Genetics Initiative Bipolar Disorder Consortium, Gershon ES, McMahon FJ, DePaulo JR, Potash JB. Association study of Wnt signaling pathway genes in bipolar disorder. Arch Gen Psychiatry 65:785-793, 2008.
Willour VL, Chen H, Toolan J, Belmonte P, Cutler DJ, Goes FS, Zandi PP, Lee RS, MacKinnon DF, Mondimore FM, Schweizer B, Bipolar Disorder Phenome Group, NIMH Genetics Initiative Bipolar Disorder Consortium, DePaulo Jr. JR, Gershon ES, McMahon FJ, and Potash JB. Family-based association of FKBP5 in bipolar disorder. Mol Psychiatry 2008 Jan 8 [Epub ahead of print]
