| Professor of Psychiatry and Neurology Director, Johns Hopkins Schizophrenia Program Director, Genetic Neurobiology Laboratory Director, Neurogenetic Testing Laboratory Co-Director, Division of Neurobiology |
Main Office Address
Division of Neurobiology
Department of Psychiatry and Behavioral Sciences
CMSC 8-121
The Johns Hopkins Hospital
600 North Wolfe St.
Baltimore, MD 21287-5371
Phone: 410-614-4262
Fax: 410-614-0013
E-mail: rmargoli@jhmi.edu
Administrative Assistant
Betty Bandell
Phone: 443-287-4962
Email: bbandell@jhmi.edu
Education and Government Service
1982 | A.B. | Princeton University |
1986 | M.D. | Johns Hopkins University School of Medicine |
1986-1987 | Medicine-Psychiatry Internship | Francis Scott Key Hospital |
1987-1990 | Psychiatry | Johns Hopkins |
1990-1992 | Neurobiology Fellowship | National Institute of Mental Health |
1990-1992 | Government Service | Public Health Service |
Professional Interests
My research interests focus on the interface of psychiatry, neurology, and genetics. A major emphasis is determining the etiology and pathogenesis of neurodegenerative disorders affecting the cerebellum and basal ganglia, and describing the psychiatric aspects of such disorders. A second emphasis is on determining the genetic risk factors for bipolar disorder, schizophrenia, and autism. My clinical interests include affective disorders, geriatric psychiatry, and neuropsychiatry.
Click here to learn more about Dr. Margolis' research
Click here and here for Hopkins Brain Wise Newsletter articles about Dr. Margolis' work
Selected Publications
Holmes SE, O'Hearn E, McInnis MG, Kwak NG, Gorelick-Feldman DA, Kleiderlein JK, Callahan C, Sherr M, Sharp AH, Sumner AJ, Ashworth RG, Ananth U, Seltzer W, Vieria-Saecker AM, Epplen JT, Reiss O, Ross CA, Margolis RL. Expansion of a novel CAG trinucleotide repeat in the 5' region of PPP2R2B is associated with SCA12. Nature Genetics, 1999:23:391-392.
Margolis RL, O’Hearn E, Rosenblatt A, Willour V, Holmes SE, Franz ML, Callahan C, Hwang HS, Troncoso JC, Ross CA. A disorder similar to Huntington’s disease is associated with a novel CAG repeat expansion. Annals of Neurology 2001:50:373-380.
Holmes SE, O’Hearn E, Callahan C, Hwang HS, Rosenblatt A, Ingersoll-Ashworth RG, Fleisher A, Stevanin G, Brice A, Potter NT, Ross CA, Margolis RL. A CTG trinucleotide repeat expansion in Junctophilin 3 is associated with Huntington's Disease-Like 2 (HDL2). Nature Genetics 2001:29:377-378.
Leroi I, O’Hearn E, Marsh L, Lyketsos CG, Rosenblatt A, Ross CA, Brandt J, Margolis RL. Psychopathology in degenerative cerebellar diseases: A comparison to Huntington’s disease and normal controls. American Journal of Psychiatry, 2002:159:1306-1314.
Sachs NA, Sawa A, Holmes SE, Ross CA, DeLisi LE, Margolis RL. A frameshift mutation in Disrupted in Schizophrenia 1 segregates with schizophrenia and schizoaffective disorder in an American family. Molecular Psychiatry 2005:10:758-64
