Division Required, Twice, Before Fat Cells Mature
Johns Hopkins School of Medicine scientists have shown for the first time
that primitive fat cells must copy themselves at least twice before they
can mature into full-fledged fat-storing cells. The finding, published
online the week of Dec. 23 in the Proceedings of the National Academy
of Sciences, may help provide new targets for understanding and treating
Pox Vaccine Ok for Children with Kidney Disease
Researchers at the Johns Hopkins Children's Center report that two doses
of the varicella vaccine for chicken pox given one to two months apart
can be safe and effective in children with chronic kidney disease.
Cancer Gene Controls Blood Vessel Growth
Scientists from the Kimmel Cancer Center at Johns Hopkins and Northwestern
University have found a new target to squeeze off a tumor's blood supply.
Research published in the December 17 issue of Cancer Cell shows
how a common cancer-causing gene controls the switch for tumor blood vessel
growth known as angiogenesis.
From Liver Disease Major Threat to Men with Hepatitis B and HIV
Men infected with a combination of hepatitis B virus and HIV are 17 times
more likely to die from liver disease than men infected with hepatitis
B alone, according to a study by researchers at Johns Hopkins published
in the Dec. 14, 2002, issue of The Lancet.
Hopkins' Urban Health Institute to Initiate New HIV/AIDS Testing Program
The Johns Hopkins Urban Health Institute, the Johns Hopkins School of
Medicine's Division of Infectious Diseases and The Men's and Rose Street
Community Centers have created a joint HIV/AIDS testing program in East
Baltimore. The project is believed to be one of the first in the region
to forge an anti-AIDS partnership among a medical center, businesses and
Named Director of Comparative Medicine at Johns Hopkins
Janice Clements, Ph.D., has been named the first director of the new Department
of Comparative Medicine at The Johns Hopkins University School of Medicine.
A faculty member at the school since 1978, Clements also holds the titles
of Vice Dean for Faculty Affairs, director
of the Retrovirus Laboratory, and professor of comparative medicine, neurology
and pathology. She had served as interim director of the Division of Comparative
Medicine since 1999.
of Seizures May Play a Role in Predicting Success of Pediatric Hemidecortication
The success of a more common and less radical form of hemispherectomy,
an operation in which half the brain is removed to relieve severe seizure
disorders that medications cannot control, depends on the cause of the
seizures, according to Johns Hopkins Children's Center researchers studying
106 patients who underwent hemidecortication from 1975 to 2001.
Drugs Convenient and Safer For Seizure Patients
Many patients with epilepsy taking a common drug to control seizures can
reduce side effects by switching from three or four short-acting doses
to two extended-release doses per day, according to researchers at Johns
Hopkins. The drug, carbamazepine, is a first-line drug used to control
partial seizures, which originate in one part of the brain and then spread
to other areas.
Too Fat to Fight?
The notion of a trim fighting force probably dates back more than 2,000 years.
Today, each branch of the U.S. armed services has developed a "Maximum
Allowable Weight" chart to screen and determine eligibility for entry
into the military. But an article published in the November issue of The
American Journal of Medicine questions whether weight alone should determine
if an individual is physically fit for service.
Deeply Divided About Use of Genetic Technologies in Reproduction
Americans are both hopeful and fearful about the rapidly advancing power
of scientists to manipulate human reproduction, according to a new survey
released today by the Genetics and Public Policy Center, a Johns Hopkins
effort funded by The Pew Charitable Trusts.
End Seizures In Many Older Children With Rare Seizure Disorder
Researchers from the Johns Hopkins Children's Center report that hemispherectomy--
a procedure in which half the brain is removed--may reduce or eliminate
severe seizures even in older children with a rare congenital disorder
associated with epilepsy. The findings are published in the December issue
Study Finds Combined PET-CT Better At Detecting Ovarian Cancer Spread
Hopkins radiologists have found that a combination of positron emission
tomography (PET) and computed tomography (CT) detects cancer spread better
than PET alone. In a study to be presented at the Radiological Society
of North America (Abstract #1458, 10:57 AM, CST, Thursday, December
5, Room S502AB), researchers reported that overall, PET-CT improves
the ability to distinguish cancerous from normal tissue and locate metastases,
where they have spread. The study used a scanner that fuses CT technology,
which provides anatomical detail, with PET images, which detects metabolic
activity of tumors.
Radiologist Stanley S. Siegelman, M.D., Awarded Gold Medal
Citing his many contributions as a scientist, teacher and editor, the
Radiological Society of North America (RSNA) has awarded its prestigious
Gold Medal to Stanley S. Siegelman, M.D., professor of radiology at Johns
Hopkins and director of its radiology residency program. The award will
be presented Dec. 3 during a special ceremony at the RSNA's annual meeting
and convention, held in Chicago.
H. Miller, M.D., Named Director of Pediatric Imaging At Johns Hopkins
John H. Miller, M.D., F.A.C.R., a pediatric radiologist and researcher
in the field of pediatric nuclear imaging, has been named director of
the Division of Pediatric Imaging at the Johns Hopkins Children's Center.
Named V.P. of Finance and Operations for Hopkins Community Physicians
Linda Gilligan has been named Vice President of Finance and Operations
for Johns Hopkins Community Physicians, a Maryland-based primary care
physician group. Her appointment was announced by Barbara G. Cook, M.D.,
President of the primary care physician group.
Yellow Molecule Comes Up Big
Bilirubin has been a mystery of a molecule, associated with better health
if there's just a little more than normal, but best known for being at
the root of the yellow color in jaundice and, at high levels, for causing
brain damage in newborns. Johns Hopkins scientists have now solved the
enigma of how this toxic molecule can also be beneficial.
Mice Are Less Susceptible To Muscular Dystrophy Gene's Effects
The Johns Hopkins scientists who first discovered that knocking out a
particular muscle gene results in "mighty mice" now report that
it also softens the effects of a genetic mutation that causes muscular
Management News Tips
When A Diet Is More Than A Diet: Eating Disorders and Young Adults; Nutrition:
Ways To Watch Your Waistline At The Holidays; Holiday Food Tips For People
J. Montz, M.D. (1955-2002)
Fredrick J. "Rick" Montz, professor of gynecology, obstetrics,
oncology and surgery at The Johns Hopkins University School of Medicine
and director of the Kelly Gynecologic Oncology Service at The Johns Hopkins
Hospital, died of a heart attack Thursday evening while jogging. He was
47. Recruited to Hopkins in 1997, he was a nationally recognized authority
on the use of minimally invasive techniques that preserved fertility in
the treatment of gynecologic cancers.
Hopkins Awarded Grant To Fund Child Injury Prevention Programs In Baltimore
The Johns Hopkins Children's Center has received a four-year, $213,380
grant from The Robert Wood Johnson Foundation to establish a nationally
recognized pediatric injury prevention program in Baltimore.
Compression Device Outperforms Manual CPR
A battery-operated compression belt buckled around the chest restores
blood flow better than manual chest compressions and conventional CPR,
according to a Johns Hopkins-led animal study.
Cancer Detected In Blood Samples
Scientists at Johns Hopkins have successfully detected ovarian cancer
using a blood test for DNA shed by tumors. The test is based on digital
analysis of single nucleotide polymorphisms (SNP, or "snips"),
in which investigators separate the two strands of code found in every
gene to search for imbalances that are a hallmark of cancer cell DNA.
Proteins Tied to Inflammation, Malnutrition Put Dialysis Patients at Higher
Risk of Heart Disease
A Johns Hopkins-led study shows that two proteins, C-reactive protein
and albumin, are accurate predictors of heart attack or stroke in kidney
dialysis patients. The research team found that high levels of C-reactive
protein, a marker of inflammation, and low levels of albumin, a sign of
malnutrition, had strong ties to heart disease in these patients, who
are many times more likely to develop heart problems than the general
Appointed to Inaugural Board of Health Information Technology Group
Stephanie Reel, M.B.A., chief information officer and vice provost for
information technology for The Johns Hopkins University and vice president
for information services for Johns Hopkins Medicine, has been appointed
to the inaugural board of directors for the National Alliance for Health
Information Technology (NAHIT).
Reproduction May Be Linked To Birth Defect Syndrome
Scientists from Johns Hopkins and Washington University School of Medicine
in St. Louis have discovered that in vitro fertilization (IVF) appears
to be associated with a rare combination of birth defects characterized
by excessive growth of various tissues.
Hopkins Researchers Find Postoperative Fevers Common Following Hemispherectomy
There is reassuring news for families and medical staff who care for children
who spike fevers following hemispherectomy, a surgery in which half the
brain is removed to relieve frequent severe seizures that
medications cannot control.
Care Specialists Reduce Hospital Death Rates by 30 Percent
Patients in an intensive care unit (ICU) whose care is managed by "intensivists"
physicians specially trained in critical care medicine have
a greater chance of survival and a shorter hospitalization, according
to researchers at Johns Hopkins and the University of Pittsburgh.
Valve" Within Heart Cells Could Protect Body During Heart Attacks
A Johns Hopkins-led research team has identified a type of control valve
within heart cells that can be switched on to help the organ survive injury
during a heart attack. The work is published in the Nov. 1 issue of Science.
Aerobic Exercise No Protection From Osteoporosis
While day-to-day physical activities such as walking, housework and shopping
may be good for your heart, they don't do much for your bones, according to
a Johns Hopkins study.
To Be Part of Major International Genetic Mapping Project
Researchers at the McKusick-Nathans Institute for Genetic Medicine at
Johns Hopkins have been funded to participate in an international effort
to catalogue human genetic variation, a project crucial in the hunt for
genes involved in such common diseases as asthma, heart disease and diabetes.
Slash Death/Disability From Brain Aneurysms
Preliminary results of a long-term study suggest that coils inserted into
burst aneurysms in the brain decrease by 25 percent the risk of patient death
and disability during the first year after the procedure, according to a report
published in the October 26 issue of The Lancet. Aneurysms are abnormal
ballooning of artery walls.
Hopkins' Response to Nursing Shortage:
Not Just the Number of Nurses, but How You Use Them
As the article on hospital nurse staffing and patient mortality in the October
23/30 issue of the Journal of the American Medical Association strikingly
points out, the critical national nursing shortage may be affecting patient
safety. With no appreciable increase in the nurse supply expected, The Johns
Hopkins Hospital is looking at ways to maximize the use of existing nursing
staffs with the ultimate goal of improving patient care quality AND increasing
the level of job satisfaction among nurses.
Head Hopkins Community Physicians
Barbara G. Cook, M.D., has been named president of Johns Hopkins Community
Physicians (JHCP), a large regional primary care group practice, with more
than 100 full-time staff physicians practicing at 18 health centers statewide.
Prior to being named president of the Johns Hopkins Medicine affiliate, Cook
was vice president for medical affairs and then acting president. Her appointment
was announced by Ronald R. Peterson, president of the Johns Hopkins Health
System and The Johns Hopkins Hospital and executive vice president of Johns
Hopkins Hospital and University to Initiate Comprehensive Program
The Johns Hopkins University's Homewood campus and all of the Johns Hopkins
Medical Institutions', East Baltimore campus have initiated a comprehensive,
automated external defibrillator (AED) program. The heart-saving project,
believed to be the first of its kind at a higher-learning institution,
will include non-patient care buildings and most high-traffic areas. When
complete, the initiative will place more than 60 defibrillators within
the medical center and university locations occupied by more than 600
people, such as laboratories, auditoriums, residence halls, gymnasiums,
parking garages and cafeterias.
To Train Chinese Researchers In Genetics
Funded by a five-year, $2 million grant from the Fogarty International
Center at the National Institutes of Health (NIH), Johns Hopkins will
establish and conduct an international training program in genetics in
conjunction with Peking Union Medical College and Peking University in
Gene Mutation Causes Huntington's-Like Symptoms, Providing Window Into
How Brain Cells Die
Researchers at Johns Hopkins have discovered a gene mutation that causes
a condition apparently identical to Huntington's Disease, helping to explain
why some people with the disorder do not have the mutation found in most
cases. The finding may help reveal why some diseases, like Huntington's,
Alzheimer's and Parkinson's, destroy some brain cells while sparing others.
Genetic Mutations In Sperm Increase With Men's Age
Scientists from the McKusick-Nathans Institute for Genetic Medicine at
Johns Hopkins may have discovered why a rare genetic disease is more common
in children born to older fathers. The disease, Apert syndrome, leads
to webbed fingers and early fusion of the skull bones and must be corrected
Hopkins Pediatrician Elected To Institute of Medicine
David Valle, M.D., professor of pediatrics, ophthalmology, and molecular
biology and genetics at The Johns Hopkins University School of Medicine,
has been elected to the National Academy of Sciences' Institute of Medicine
(IOM), a prestigious body that brings together national leaders in the
fields of health and medicine, social and behavioral sciences, law, administration
and economics to develop solutions to a broad range of health policy issues.
to Host East Coast Premiere of James Bond Die Another Day Gala
Screening to Benefit Hopkins Cardiovascular Center
Sporting his usual gadgets, girls and gripping adventures, James Bond
is expected to thrill moviegoers at the East Coast premiere of Die Another
Day on Wednesday, Nov. 20, at The Historic Senator Theatre.
Genome-Wide Scanning Unravels Complex Birth Defect
Researchers from the McKusick-Nathans Institute for Genetic Medicine at
Johns Hopkins have successfully used genome scanning technology to search
through thousands of DNA bits, from every chromosome, to identify two
genes that cause an inherited intestinal disorder by working together.
Fibrosis Gene Mutations Missing From Some Cases
A new study from Johns Hopkins finds that some patients diagnosed with
cystic fibrosis (CF) lack any of the more than 1,000 reported disease-causing
mutations in the only known CF gene. Scheduled for presentation Oct.
18 at the annual meeting of the American Society for Human Genetics in
Baltimore, the findings also recently appeared in the New England
Journal of Medicine.
Hopkins Researchers Report from the American Society of Anesthesiologists
Hopkins Team Identifies Risk Factors for Hospital Admission Following
Parp Enzyme Contributes to Brain Cell Death after Cardiac Arrest; Hopkins
Researchers I.D. Protein That Enables Chronic Nerve Pain
Hopkins Gets Federal Proteomics Center Contract
Johns Hopkins has won a seven-year, $18 million contract from the National
Heart, Lung and Blood Institute (NHLBI) to create one of ten centers nationwide
dedicated to the study and application of proteomics.
Medications A Good Bet For Shingles-Related Pain
Despite worries over side effects, morphine and other opiates appear
to be effective in treating shingles-related nerve pain in older adults,
a study at Johns Hopkins suggests.
Management News Tips
Story ideas from The Johns Hopkins Weight Management Center: How Many
Calories in Your Water? The Truth About Fitness Waters; Pounds Stay Away!
How to Maintain Healthy Eating Habits During the Winter; Exercises To
Fight Weight Gain; Freshman Weight Gain: What to Do?
Intervention Helps Cardiac Patients Manage Cholesterol
Patients who get follow-up care from a nurse after heart bypass surgery
are more likely to control cholesterol and reduce risk of further disease,
according to a study from The Johns Hopkins University School of Nursing.
Case of West Nile Virus at Hopkins
State Health Department officials have confirmed the first case of West
Nile virus in a Hopkins patient. The kidney transplant patient, who received
the organ from a living donor on September 6, 2002, was discharged September
14, but readmitted September 16 and died October 1. Privacy and confidentiality
policies prohibit us from giving further information about this individual.
Inspection: A Low-Tech Tool for Reducing Cervical Cancer Rates
Visual inspection of the cervix, or neck of the womb, coupled with immediate
treatment of any abnormalities may be the most cost-effective, comprehensive
way to reduce cervical cancer in Thailand and other poor nations, according
to researchers at Johns Hopkins and Georgetown universities. The scientists,
who worked with reproductive health experts in Thailand, published their
results in today's issue of the Journal of the National Cancer Institute.
Use of the Drug 'Ecstasy' Causes New Kind of Brain Damage
Researchers at Johns Hopkins have found that doses of the popular recreational
drug "Ecstasy" similar to those that young adults typically
take during all-night dance parties cause extensive damage to brain dopamine
neurons in nonhuman primates. Brain dopamine cells help control movement,
emotional and cognitive responses, and the ability to feel pleasure, according
to the study, published in the September 27 issue of Science. The
findings may also shed light on the mechanisms by which Ecstasy damages
Elected President of Society of Hospital Pharmacists
Daniel M. Ashby, M.S., FASHP, director of pharmacy at The Johns Hopkins
Hospital, was elected president of the American Society of Health System
Pharmacists (ASHP) board earlier this month. The term of his presidency
is for one year and will commence June 2003.
Genome-Wide Scanning Unravels Complex Birth Defect
Researchers from the McKusick-Nathans Institute for Genetic Medicine at
Johns Hopkins have successfully used genome scanning technology to search
through thousands of DNA bits, from every chromosome, to identify two
genes that cause an inherited intestinal disorder by working together.
Best Dressed Sale Set For September 26-29
Some Baltimore traditions just keep getting bigger and better. That's
certainly the case with this year's Johns Hopkins Best Dressed Sale and
Boutique 2002. Exclusive designer dresses and shoes, chic contemporary
fashions, classic accessories and enduring vintage clothing will be on
the racks, waiting for a favored place in the closets of bargain-conscious
shoppers. All money raised goes to support The Johns Hopkins Hospital
and its patients.
Offers Non-Laser Correction Farsightedness
Surgeons at Johns Hopkins' Wilmer Eye Institute are now offering conductive
keratoplasty, or CK, to correct low-level farsightedness in selected patients
over age 40.
Hopkins Begins Enrolling Current and Former Smokers in New National CT
Lung Cancer Screening Trial
Current and former smokers are needed for a new study to learn if screening
people with either CT scans or chest X-ray before they have symptoms can
reduce deaths from lung cancer. The National Lung Screening Trial (NLST),
launched today by the National Cancer Institute (NCI), will enroll 50,000
participants and take place at Hopkins and 29 other sites throughout the
Evaluation Critical For Kidney Disease Patients' Survival
Kidney disease patients are at a much increased risk of death when they
have delays getting to a specialist, a Johns Hopkins-led study shows.
Delays occur more often among black males, the uninsured and those who
have multiple illnesses.
Hopkins Again Named An Evidence-Based Practice Center
The Agency for Healthcare Research and Quality (AHRQ) has renewed Johns
Hopkins' status as one of its 13 Evidence-based Practice Centers in the
United States and Canada. AHRQ is the federal agency for enhancing the
quality and effectiveness of health care services.
Hopkins Hospital Wins Consumer Choice Award In Baltimore and D.C.
The Johns Hopkins Hospital again has earned the Consumer Choice Award
for both the Washington and Baltimore regions from the National Research
Corporation (NRC). Hopkins is one of the few individual hospitals in a
dual-market region selected as the top choice for health care by consumers.
of East Baltimore Medical Center
On Saturday, Sept. 21, at 10 a.m., the East Baltimore Medical Center (EBMC)
will host a re-opening ceremony to mark the completion of its $5 million
renovation. The extensive upgrades include a new Ob/Gyn and pediatric
unit and an enlarged, updated Care Plus After Hours department that provides
urgent care for local residents after hours and on weekends
Disease Gene Linked To Prostate Cancer
Researchers at Johns Hopkins, Wake Forest, and The National Human Genome
Research Institute have implicated mutations in a "heart disease
gene" in hereditary prostate cancer. The findings, which offer new
evidence that at least some cases of prostate cancer may begin with an
infection and inflammatory response, will be published online September
16, 2002, in Nature Genetics.
Researchers Study Heart Defect that Kills Athletes
Physicians at Johns Hopkins, with colleagues around the globe, are seeking
families to help them learn more about a rare heart condition that kills
athletes and seems to run in families.
Biologic Pacemaker Created By Gene Therapy In Guinea Pigs
Working with guinea pigs, Johns Hopkins scientists have created what is
believed to be the first biologic pacemaker for the heart, paving the
way for a genetically engineered alternative to implanted electronic pacemakers.
The advance, reported in the Sept. 12 issue of Nature, uses gene
therapy to convert a small fraction of guinea pigs' heart muscle cells
into specialized "pacing" cells.
More Likely To Lose Limbs Due To Vascular Disease Than Other Groups
Researchers at the Johns Hopkins physical medicine and rehabilitation
department report that African Americans with vascular disease are up
to four times more likely to have lower limb amputations than those of
other groups with the same medical conditions.
Listed below are story ideas from The Johns Hopkins Kimmel Cancer Center
useful for marking Gynecologic Oncology Awareness Month (September). Further
information about ovarian, uterine and cervical cancers is available at www.hopkinskimmelcancercenter.org
Joints Associated With Chronic Fatigue Syndrome, Researchers Find
Researchers at Johns Hopkins Children's Center report that children and
teens with chronic fatigue syndrome (CFS) are three and a half times more
likely to have hyperflexible joints than their healthy counterparts.
Studies Show Most Intersex Adults Happy With Gender Assignment at Birth,
But Need More Counseling
Researchers at Johns Hopkins Children's Center report that adults born
with ambiguous genitalia -- or malformations that make it difficult to
determine sex of rearing -- were generally content with the gender assigned
to them at birth by their parents and doctors. A companion study showed
that almost half of adult intersex patients knew little about their condition,
and would like to know more.
Hopkins to Host Forum on Hormone Replacement Therapy Sept. 18
Two Johns Hopkins physicians will lead a discussion about hormone replacement
therapy, in a forum designed to help Baltimore-area women find answers
to their questions about the use of hormones during and after menopause.
The event will be held Wednesday, Sept. 18, from 7 p.m. to 9 p.m. at Shriver
Hall on the University's Homewood campus.
Hopkins Establishes Enterprise-Wide Office To Deal With Terrorism, Disaster Response
In a move to use and integrate more of the resources and expertise of the
Johns Hopkins Institutions to deal with terrorism and other disasters, Hopkins
officials have established the Office of Critical Event Preparedness and Response
Therapies Could Prevent Damage From Kidney Failure
Targeting sugars that occur naturally in the body could protect the kidneys
or other organs from damage associated with disease or injury, according
to a Johns Hopkins study.
Hankins joins Wilmer Eye Institute at Johns Hopkins
Laurette Hankins has been named director of development for the Wilmer
Eye Institute at Johns Hopkins. Hankins, of Severna Park, Md., had been
director of development for Severn School, a college preparatory school
in Severna Park, for the past year
Possibilities For Treating Childhood Brain Cancer
The most common brain cancer in children may have an Achilles' heel --
the signal from a protein called Hedgehog -- according to a report in
the Aug. 30 issue of Science.
Kidney Transplant Technique Prevents Rejection of Donated Organs
Johns Hopkins physicians report an extraordinarily high success rate for
kidney transplants among patients traditionally considered ineligible
for the surgery.
Signaling Pathway Has New Route
The celebrated signaling pathway called Hedgehog, crucial in proper embryo
development and implicated in some cancers, has a new twist, Johns Hopkins
scientists report in the August 22 issue of Nature.
Damage In Infants Not Always Tied To Delivery
Neurological problems in newborns, including seizures, do not necessarily
stem from delivery, a Johns Hopkins study demonstrates.
Anti-Inflammatory Drug Reduces Growth of Cancerous Tumors In Rats
Research led by a nurse investigator at Johns Hopkins has found that a
pain reliever commonly used to treat serious and painful forms of arthritis
may also reduce the growth of malignant tumors after cancer surgery. Indomethacin,
a nonsteroidal anti-inflammatory drug, given to rats after surgery reduced
tumor promotion by more than 50 percent, according to Gayle Page, associate
professor at The Johns Hopkins University School of Nursing. Her study
results appear in the August issue of the Journal of Pain.
Anderson, Johns Hopkins Physician, Dies
Norman D. Anderson, M.D., an associate professor of medicine and surgery
at The Johns Hopkins University School of Medicine and one of the first
physicians to urge the U.S. Food and Drug Administration (FDA) to recall
silicone gel breast implants, died Aug. 15 of complications from gastric
cancer. He was 69.
"Jumping Genes" Create Ripples in the Genome- -and Perhaps Species' Evolution
Laboratory experiments led by Hopkins scientists have revealed that so-called
"jumping genes" create dramatic rearrangement in the human genome
when they move from chromosome to chromosome. If the finding holds true
in living organisms, it may help explain the diversity of life on Earth,
the researchers report in the current (Aug. 9) issue of Cell.
Gene Found in Children with Down Syndrome
Scientists from Baltimore and Chicago have found a gene defect that seems
to lead to leukemia in children with Down syndrome. The discovery might
offer a way to speed accurate diagnosis and provide new targets for treating
the cancer, they report in the Aug. 12 online version of Nature Genetics.
Management Center- SOURCE NOTE
An experiment on both animals and humans, reported in a recent issue of
the journal Nature, might help scientists develop a new drug to
curb appetite. Lawrence J. Cheskin, M.D., F.A.C.P., director of the Johns
Hopkins Weight Management Center http://www.jhbmc.jhu.edu/weight/
and associate professor of Medicine and Human Nutrition at Johns Hopkins,
is available to discuss the study and its findings.
of Key Receptor Unlocked; Related Proteins Will Fall Like Dominoes
After two years of stubborn persistence, scientists at Johns Hopkins have
determined the 3-D structure of part of a protein called HER3, which should
speed efforts to interfere with abnormal growth and cancer.
Psychiatric Symptoms Common With Degenerative Brain Disease
Potentially treatable psychiatric problems are common in patients with
degenerative brain diseases affecting movement and coordination, according
to a study by Johns Hopkins scientists. Up to 80 per cent of those with
either Huntington's disease or degenerative diseases affecting the cerebellum
also suffer from depression, impaired thinking and changes in personality,
the study found.
Surprise, Surprise: Hopkins Scientists Unexpectedly Create Epilepsy In Rats
One of the brain's most important chemical messengers has led Johns Hopkins
School of Medicine researchers on a wild ride. Primarily interested in how
and why nerve cells die in neurodegenerative diseases like Lou Gehrig's disease,
the scientists now find themselves with a new rat model of epilepsy, a disease
characterized not by cell death, but by rapid and uncontrolled "firing"
of brain cells.
Human X Chromosomes Doesn't Use Same Gene as in Mouse
A gene thought to keep a single X chromosome turned on in mice plays no
such role in humans, Johns Hopkins researchers report in the August issue
of the American Journal of Human Genetics.
Families with Marfan Syndrome to Attend Genetics Clinic at Johns Hopkins
as Part of International Conference in Baltimore
Johns Hopkins and the National Marfan Foundation will host an international
conference, July 31-Aug. 4, in Baltimore, designed especially for children
and adults with Marfan syndrome and other related connective tissue disorders.
Owsei Temkin, Renowned Historian of Medicine, Dies
Owsei Temkin, M.D., former director of the Institute of the History of
Medicine at The Johns Hopkins University and William H. Welch Professor
Emeritus, died on Thursday, July 18. He was 99.
To Hold Mock Disaster Drill at White Marsh
On July 23, at 5 p.m., Johns Hopkins Community Physicians (JHCP), a member
of Johns Hopkins Medicine providing primary and secondary care to over
100,000 patients throughout central Maryland, will face an unimaginable
medical disaster --- detonation of a "dirty" radiation bomb
in northern Baltimore County.
Hopkins Offers Postdoctoral Training Program in Biomedical Information Sciences
With a $3.3 million National Library of Medicine Medical Informatics Research
Training Program grant, the Johns Hopkins Division of Health Sciences
Informatics will offer a two-year postdoctoral program for health professionals
and others with information or computer science backgrounds, with a special
track for librarians. The growing field of health sciences informatics
research is concerned with understanding information needs and designing,
implementing and evaluating innovative information systems and services
in the health sciences.
Cells' Death Different From Other Cells'
Writing in the July 12 issue of the journal Science, Hopkins-led
researchers say they have identified in neurons a novel form of "programmed"
cell death unlike those already known -- apoptosis and necrosis.
Blocker May Be Potential Liver Cancer Treatment
A team of Johns Hopkins researchers has identified and successfully tested
in animals a potential new treatment for liver cancer, a disease for which
there are few effective treatments.
Johns Hopkins Hospital Tops U.S. News & World Report's "Honor Roll"
12 Years in a Row
For the 12th consecutive year, U.S. News & World Report's annual
ranking of American hospitals has placed The Johns Hopkins Hospital at
the top of the list.
Home Care Group Affiliates with the Washington Home for End-of-life Care Services
The Johns Hopkins Home Care Group (JHHCG) and Community Hospices, part of
The Washington Home (TWH), a nonprofit, Washington, D.C.-based healthcare
facility, have entered into an agreement to provide hospice services to patients
of the Johns Hopkins Health System.
for ALS Research at Hopkins Named for Robert Packard
In recognition of a $5 million commitment from The Robert Packard Foundation,
Hopkins' Center for ALS Research is being renamed the Robert Packard Center
for ALS Research at Johns Hopkins in a 5 p.m. ceremony, Friday, July 12,
at the Phipps Building at the Johns Hopkins School of Medicine campus.
Media are invited to attend.
Hemoglobin Means High Risk For Mobility Problems In Elderly Women
The amount of oxygen-carrying hemoglobin circulating in the blood of older
women could have an impact on the risk for mobility problems, Johns Hopkins
physicians have found.
Gene Control Increases Chances Human Stem Cells Will Be Safe
Johns Hopkins School of Medicine researchers have what is believed to
be the first solid evidence that genes in human pluripotent stem cells
and their progeny work normally.
Scientists Return to the Mouse to Overcome Some Obstacles In Working with
Human Stem Cells
Learning about human stem cells requires working with them, but some Johns
Hopkins researchers are turning to a clever new mouse model to learn things
the human cells can't teach them.
C Infection Does Not Alter HIV Progression or Treatment
Resolving conflicting reports about the effect of hepatitis C virus infection
on the progression of HIV disease, a Hopkins study of nearly 2,000 HIV
patients shows that hepatitis C does not increase risk of death, accelerate
the development of AIDS, or curb the value of antiretroviral HIV therapy.
OK For Most Heart Disease Patients But Could Be Dangerous For Others
Walking the golf course while pulling a cart provides safe and adequate
exercise for most people with heart disease, according to researchers
at Johns Hopkins and Wake Forest universities. But patients should check
with their health care provider before teeing off, they say.
Gets An Ace For Holding Off Heart Disease
Men who start playing tennis in their youth and are good at it are likely
to continue playing the sport for years, thereby keeping heart disease
at bay well into middle-age, a Johns Hopkins study shows.
News About Oral Contraceptives
A new study reverses the long held notion that birth control pills increase
a womens risk for breast cancer. Breast cancer experts at Johns
Hopkins say these newest results confirm that taking birth control pills,
even for a long time, does not appear to increase a womans risk
for breast cancer and reduces their risk for endometrial and ovarian cancers.
Their editorial appears in the June 27, 2002, issue of the New England
Journal of Medicine.
Making at the Cellular Level
Its a wonder cells make it through the day with the barrage of cues
and messages they receive and transmit to direct the most basic and necessary
functions of life. Such cell communication, or signal transduction, was
at least thought to be an "automatic" cascade of biochemical
events. Now, however, a study reported in a recent issue of Nature
by Johns Hopkins and Harvard scientists has found that even before
a message makes it through the outer cell membrane to the inner nucleus,
the cell is busy activating a molecular switch to guide how the message
will be delivered in the first place.
Researchers to Lead Independent Study of "Next Generation" Ethics
Issues in Stem Cell Research
A pioneering Johns Hopkins stem cell expert and one of the institution's
leading bioethicists have won a multi-year grant from the Greenwall Foundation
to develop far-reaching recommendations on a "second generation"
of ethical questions about stem cell research.
Stem Cell Seminar
Draws National Media
Using brain cells from rats, scientists at The Johns Hopkins University
School of Medicine and the University of Hamburg have manipulated a molecular
"stop sign" so that the injured nerve cells regenerate.
"Stop Signs" May Hold Secret of Nerve Regeneration
Using brain cells from rats, scientists at The Johns Hopkins University
School of Medicine and the University of Hamburg have manipulated a molecular
"stop sign" so that the injured nerve cells regenerate.
Loss Syndrome Created in Mice
Inactivating just one of more than two dozen similar genes can cause temporary
but profound hair loss, known as alopecia, in mice, researchers from Johns
Hopkins and the Pasteur Institute in France report in the June issue of
Genes & Development.
Antibiotic Ointment Reduces Infection Risk after Surgery
In what may be the largest clinical trial to evaluate the effectiveness
of antimicrobial agents in preventing surgical wound and hospital-based
infections caused by Staphylococcus aureus, scientists at the University
of Iowa and Johns Hopkins found that an antibiotic ointment, called mupirocin
(moo-PIE-roe-sin), smeared inside the nose cut infection rates in half
Eye Drops May Delay Glaucoma
Eye drops used to reduce elevated pressure inside the eye may delay the onset
of glaucoma among people at high risk for the condition, according to a study
by researchers at Johns Hopkins' Wilmer Eye Institute and 21 other institutions
throughout the United States.
to Cement Spine Now Simpler
Johns Hopkins interventional radiologists have demonstrated that cement
can be injected into the spine without prior, potentially dangerous dye
To Receive Honorary Degree
Solomon H. Snyder, M.D., winner of a Lasker Award for his discoveries
in brain chemistry, and University Distinguished Professor of Neuroscience,
Pharmacology and Psychiatry at The Johns Hopkins University School of
Medicine, is to receive an honorary degree from Israels Technion-Institute
of Technology at ceremonies in Haifa, Israel, June 10.
Violence Causes Long-Term Health Consequences for Women
A Johns Hopkins University School of Nursing study concludes female victims
of physical and/or sexual abuse have a significantly higher rate of common
health problems, even after the abuse ends, compared to women who have
never been abused.
New Drug Shows Promise in Common and Lethal Form of Leukemia
A new drug blocks the impact of a cancer-causing gene mutation found in
a common and lethal form of leukemia, say researchers at the Johns Hopkins
Kimmel Cancer Center. Their findings in animal and test tube models are
featured the June 1, 2002, issue of Blood.
Protein Is Part of Amoeba's Compass
Researchers from the Johns Hopkins School of Medicine have learned that a
protein that prevents the formation of cancerous tumors in animals also helps
single-celled amoeba determine direction, particularly when moving toward
a chemical attractant, an ability of many cell types in more complex creatures.
Jeffery Williams, Hopkins Neurosurgeon, Dies at 50
Jeffery A. Williams, M.D., associate professor of neurosurgery and oncology,
and director of stereotactic radiosurgery at The Johns Hopkins School of Medicine,
died suddenly on Saturday, May 26. He was 50.
McKusick Lecture Scheduled For May 30, 4 P.M.
The inaugural lecture honoring the life and work of Hopkins physician
Victor A. McKusick, M.D., will be delivered by Sir David Weatherall, Emeritus
Regius Professor of Medicine at the University of Oxford, Thursday, May
30, 2002, at 4 p.m., in the auditorium of the Wood Basic Science Building
(725 N. Wolfe
Studying Genetic Modifications In Disease Meet At NIH
The first conference on Epigenetic Mechanisms in Human Disease will be
held next Thursday and Friday, May 30 and 31, 2002, at the Natcher Conference
Center at the National Institutes of Health, Bethesda. During this unprecedented
meeting, researchers will share their experiences in studying how a range
of epigenetic mechanisms -- changes to genes other than mutations in the
gene's sequence -- influence a wide variety of human diseases, including
cancer, birth defects and psychiatric conditions.
Named A Howard Hughes Medical Institute Investigator
Johns Hopkins AIDS researcher and immunologist Robert F. Siliciano, M.D.,
Ph.D., has been named a Howard Hughes Medical Institute (HHMI) investigator.
He is one of 12 physician- scientists recently selected by HHMI for their
achievements in patient-oriented research.
Component Kills Bacterial Cause of Ulcers and Stomach Cancer
A bacterium responsible for the vast majority of stomach cancers, a leading
cause of cancer death worldwide, and ulcers may have met its match, scientists
from Johns Hopkins and the French National Scientific Research Center
report in the May 21 online edition of the Proceedings of the National
Academy of Sciences.
King, Former Hopkins Hospital V.P., Dies
Theodore M. King, M.D., Ph.D., former vice president for medical affairs
at The Johns Hopkins Hospital and a former chairman of the Johns Hopkins Department
of Gynecology and Obstetrics, died on Wednesday, May 22. He was 71.
To Establish Gamma Knife Center To Treat Brain Tumors, Other Brain Abnormalities
The Johns Hopkins Hospital is establishing a new $4.5 million Gamma Knife
Center to provide advanced treatment for brain tumors and other neurological
Protein Causes Muscle Wasting Syndrome In Mice
The Johns Hopkins researchers who first identified myostatin as a key restrictor
of muscle growth in animals now report that excessive amounts of the protein
in mice cause rapid and dramatic loss of both muscle and fat, without affecting
Pain Pumps Improve Cancer Patients' Quality of Life
An implantable pump that delivers pain medication in a slow-release fashion
directly into the spinal fluid could greatly improve the pain relief, overall
quality of life and survival for cancer patients living in pain, according
to an international study completed at Johns Hopkins, the Medical College
of Virginia and 25 other medical centers.
Commencement Speaker for Hopkins School of Medicine
The Johns Hopkins University School of Medicine will award doctor of medicine
degrees to 114 women and men from 25 states and six foreign countries
at the commencement exercises May 23, 2002. The class is the 107th to
graduate since the school opened in 1893. Johns Hopkins is among the most
selective medical schools in the nation, with 4,654 applicants for 120
places for the freshman class this fall.
Alone After Surgery Still the Standard for Head and Neck Cancer
A preliminary study has found no advantage to adding chemotherapy to radiation
after surgery for treating advanced head and neck cancer patients. The
findings of the research, to be presented at the American Society of Clinical
Oncology meeting May 18, appear to set aside earlier data suggesting that
a combination of chemotherapy and radiation would improve the odds of
staying cancer-free after surgery. Results are published in abstract #
903 in the ASCO Program/Proceedings.
Hopkins Community Physicians to Celebrate 20-Year Anniversary of Uniformed
Services Family Health Plan
Johns Hopkins Community Physicians will host a ceremony on Friday,
May 17, 2002 to celebrate the 20th Anniversary of legislation allowing
uniformed services beneficiaries and their families to receive medical
care at Wyman Park Medical Center, a Uniformed Services Treatment Facility
(USTF) established in 1981.
Therapy Reported for Children, Adults with End-stage Liver Disease
A Johns Hopkins Children's Center scientist reports success in animal
studies in preventing a cascade of brain pathology that appears to both
cause and signal the final and fatal stages of acute and chronic liver
disease in children and adults. The findings ("Hyperammonemic Encepalopathy")
appear in the May issue of Medicine.
Powerhouse Enzyme Linked to Cancer Development
Scientists at the Johns Hopkins Kimmel Cancer Center have discovered that
an enzyme found in a tumor cell's energy center has a special relationship
with a gene that controls cancer cell growth and death. Their findings,
published in the May 14 issue of the Proceedings of the National Academy
of Sciences, may offer a road map to anti-cancer therapies designed to
manipulate the genetic pathway that switches the enzyme on and off.
"Father of Genetic Medicine," To Get National Medal of Science
Victor A. McKusick, M.D., University Professor of Medical Genetics at
The Johns Hopkins University School of Medicine and a physician-scientist
widely acknowledged as the father of genetic medicine, is to receive a
National Medal of Science from President George W. Bush at White House
ceremonies. The date of the ceremonies has not been set.
Co-hosts One of the Largest Dermatology Conferences in the Country
The 79th Annual Atlantic Dermatology Conference will bring together more
than 400 dermatologists to discuss recent developments in scientific research
and patient care. The conference will be held May 10-12, 2002 at the Marriot
Waterfront Hotel on Baltimore's Inner Harbor.
and Stem Cell Science: Our Capabilities, Our Conscience
Few scientific discoveries have ignited an ethical, medical and legal
furor as has the isolation and culture of human pluripotential stem cells
and their potential application for treating humans. Researchers, government
officials, ethicists, and religious and other groups are debating hotly
the use of stem cells and their potential to treat such diseases as Alzheimer's,
Parkinson's, coronary heart, stroke, and diabetes, as well as traumatic
injuries to nerves. Last fall, President Bush authorized federal funding
of research using only the existing stem cell lines, a decision that has
satisfied few. Just weeks ago, he reiterated his opposition to therapeutic
Medicine News Tips
Listed are story ideas from The Johns Hopkins University School of Medicine's
Division of Sports Medicine. ACL Injuries as Common as "Three-pointers";
Weekend Warriors, Beware! How to Tell If Your Injury Is Serious; Tennis.
Hopkins Medicine Sets $1 Billion Campaign Goal
The goal of "The Johns Hopkins Campaign: Knowledge for the World"
is to raise $2 billion in private philanthropy to build or upgrade facilities
on all Hopkins campuses, to strengthen endowment for student aid and faculty
support, and to advance research, academic and clinical initiatives.
Hopkins Scientists Reveal How Sound Becomes Electric
Scientists from The Center for Hearing and Balance at Johns Hopkins have
discovered how tiny cells in the inner ear change sound into an electrical
signal the brain can understand.
Filtering Patient's Blood Before Kidney Transplant Allows Transplant From
By filtering kidney patients' blood of antibodies that normally would
reject a donor kidney, transplant surgeons at Johns Hopkins have been
93 percent successful in transplanting the organs between any two people
regardless of blood type or prior exposure to their tissue type.
Beachy Elected to National Academy of Sciences
Johns Hopkins molecular biologist Philip A. Beachy, Ph.D., has been elected
to the National Academy of Sciences, an honorary society whose members
advise the government on scientific matters.
Johns Hopkins Dedicates Sidney Kimmel Comprehensive Cancer
On May 4, 2002, Johns Hopkins hosts a celebration honoring the largest benefactor
in its history, Sidney Kimmel for his gift of $150 million to be used for
cancer research, patient care, and a new patient and family pavilion. Mr.
Kimmel, who earned his billion-dollar fortune as chairman and founder of the
Jones Apparel Group, pledged to devote it to finding a cure for cancer.
Need, Potential for Hepatitis C Vaccine Highlighted by Hopkins Study
Humans may be able to develop immunity to hepatitis C virus, according
to a study by Hopkins researchers published in the April 26 issue of The
Lancet, findings that add to a growing body of evidence that immunity
to the virus can be acquired. The findings are important because no vaccines
exist for preventing hepatitis C in humans although preliminary vaccine
research in primates appears promising.
Manganese Blocks HIV Replication; Lab Finding Points to Potential New
Class of HIV Treatments
Johns Hopkins scientists have found that simply increasing manganese in
cells can halt HIV's unusual ability to process its genetic information
backwards, providing a new way to target the process's key driver, an
enzyme called reverse transcriptase.
Reitz Named "Distinguished Woman" By Girl Scouts of Central
Judy A. Reitz, Sc.D., executive vice president and chief operating officer
at The Johns Hopkins Hospital, was honored recently as one of five Girl
Scouts of Central Maryland Distinguished Women of 2002. The award honors
women who best exemplify the ideals of ethics, leadership and character
that each Girl Scout strives to achieve, the organization says.
David Nagey, Hopkins' Director of Perinatal Outreach, Dies at 51
David A. Nagey, M.D., Ph.D., director of perinatal outreach for The Johns
Hopkins University School of Medicine and a consulting perinatologist
for 10 Maryland hospitals, died suddenly on Sunday, April 21. He was 51.
Angry Young Men Prone To Premature Heart Disease
Young men who quickly react to stress with anger are at three times the
normal risk of developing premature heart disease, according to a Johns
Hopkins study of more than 1,000 physicians.
Hopkins Is One Site for International Study on Noninvasive Treatment of
The Johns Hopkins Hospital is one of eight worldwide sites chosen to conduct
a Phase 3 clinical trial on the treatment of uterine fibroids using magnetic
resonance imaging (MRI)-guided high intensity focused ultrasound.
16th Annual Depression Symposium Features Pulitzer Prize-Winning Author,
Author William Styron and pediatric neurosurgeon Benjamin Carson, M.D.,
will be featured speakers at the annual symposium sponsored by the Johns
Hopkins Affective Disorders Clinic and DRADA, the Depression and Related
Affective Disorders Association.
Hopkins Researchers Test New Molecular Marker for Prostate Cancer
Hopkins cancer researchers have identified a new genetic culprit-with
dietary links-in the initiation of prostate cancer. Their findings are
reported in the April 15, 2002, issue of Cancer Research.
Angioplasty Beats Clot-Busting Drugs For Most Heart Attack Patients
Heart attack patients may be better off with balloon angioplasty to open
blocked blood vessels than with clot-busting drugs, even if their hospital
lacks a cardiac surgery program, according to a Johns Hopkins-led study.
Scientists Close In On Trigger Of Insulin Resistance
In experiments with fat cells, Johns Hopkins scientists have discovered
direct evidence that a build-up of sugar on proteins triggers insulin
resistance, a key feature of most cases of diabetes.
Scientists Unravel Complicated Genetic Disease In One Fell Swoop
Scientists consider themselves lucky when an inherited disease is due
to a single gene, like Huntington disease, for example. But most inherited
diseases arise from a number of genetic changes that add up to trouble,
making it difficult for geneticists to find everything that's to blame.
WEIGHT MANAGEMENT NEWS TIPS
Story ideas from The Johns Hopkins Weight Management Center: The USDA's
Attempt To Expand Serving Sizes Comes Under Fire; What Does This Food
Label Mean?; Fad Dieters -Beware!; Setting Weight Loss Goals
The Next Generation of Scientists Recognized at Johns Hopkins
The best of the best. The cream of the crop. Clichés may accurately
describe the winners of this year's Young Investigators' Day awards at
The Johns Hopkins University School of Medicine, but their work is anything
but run of the mill.
A Look Back: Twenty-Five Years of Recognizing Hopkins Researchers-In-Training
A lot has happened since 1978. Kings have fallen, conventional wisdoms
have been squashed, villains slain and heroes brought to light. And that's
just in laboratory dishes. The pace of discovery at Johns Hopkins, arguably
the first medical school in the country to integrate basic science and
clinical medicine in education and research, is quickened by the sharp
and curious minds of "young investigators" -- graduate students,
medical students and postdoctoral fellows.
2002 Young Investigators' Day Award Winners
Young Investigators' Day awards at The Johns Hopkins University School
Prostate Cancer May Result From Chronic Inflammation
The earliest stages of prostate cancer may develop in lesions generally
associated with chronic inflammation and might be reversible with anti-inflammatory
drugs and dietary supplements, new research suggests. Hopkins Kimmel Cancer
Center researchers screened several stages of normal and cancerous prostate
cells for changes in a key gene, called glutathione S-transferase p (GSTP1),
that detoxifies environmental carcinogens and protects against cancer.
In prostate cancer, this gene is deactivated through a biochemical process
known as hypermethylation. Methylation acts like the safety on a gun,
causing a gene to stop working.
Smart Bomb Therapy For Prostate Cancer
Hopkins Kimmel Cancer Center researchers are exploring new ways to deliver
targeted prostate cancer therapy by linking anti-cancer drugs to protein
carriers that are activated by prostate specific antigen (PSA). When these
so-called "pro-drugs" reach prostate tumors, PSA clips off the
protein carrier freeing the drug to kill cancer cells. Pro-drugs may be
most helpful in reaching prostate cancers that have spread to other parts
of the body. PSA, produced only by prostate cells and prostate cancer
cells, is shut down when it gets into the blood, but is found in high
levels surrounding prostate tumors.
U.S. News & World Report Ranks Hopkins in Top Two Medical Schools
The attached letter from the Dean of The Johns Hopkins University School
of Medicine thanks his faculty and staff for once again making the School
of Medicine one of the top rated in U.S. News & World Report's annual
ranking of the nation's 125 accredited institutions. The Hopkins School
of Medicine is ranked number two in the nation, a position it has held
for the past 12 years. The letter offers other details, including significant
ranking gains in several other Hopkins specialty medical programs from
Glaucoma Leading Cause of Blindness in Hispanics
Glaucoma is the leading cause of blindness among U.S. Hispanics, while
cataracts are the leading cause of visual impairment, according to results
of a national study led by Johns Hopkins researchers.
Anti-Inflammatory Drug Fails to Prevent a Hereditary Colon Cancer
The anti-inflammatory drug sulindac may not have the colon cancer prevention
properties once hoped for, say Johns Hopkins Kimmel Cancer Center researchers.
Results of a four-year study, described in the April 4, 2002 issue of
the New England Journal of Medicine, show that sulindac did not prevent
precancerous growths, called polyps, in young patients with a hereditary
form of colon cancer. The drug may still have benefit in reducing polyps
in older patients.
Urban Health News Tips
Story ideas from The Johns Hopkins Medical Institutions: High School Student
Mentored by One of Hopkins Best; Not Just Busy Work; Blacks Get Lower
Quality Asthma Care; In God We Heal?; Church and Cardiovascular Health
Coffee Raises Blood Pressure, Though Not by Much|
There's good news and bad news for java junkies. Modest coffee drinking
is associated with a small increase in blood pressure, Johns Hopkins investigators
say, but it's probably not enough to substantially increase your risk of
Hopkins' Top Researchers Share Their Love of Science with Kids|
Hopkins basic sciences researchers think science is cool and they want to
show neighborhood children why they think so. On March 28, 90 elementary
school students will spend the day in the laboratories of some of the most
prominent scientists in the world for the second annual Johns Hopkins Community
of Medicine Students Meet Their Match|
Hugs, high-fives, cheers and kisses filled the room Thursday when
Johns Hopkins University School of Medicine seniors found out which residency
programs they will enter after graduation this spring.
Treadmill Exercise Tests Point out Hidden Heart Disease|
Two Johns Hopkins studies have strongly affirmed the value of treadmill
exercise tests in diagnosing heart disease in middle-aged women and men
before symptoms occur.
The Building Blocks of Erection: Nitric Oxide . . . and More Nitric Oxide|
A team of Hopkins scientists has greatly advanced the science of penile
erection, showing for the first time the mechanism for continued production
of nitric oxide that maintains an erection over time. The findings are published
in the March 19 issue of the Proceedings of the National Academy of Sciences.
Soy Reduces Pain, Inflammation in Rats|
A diet rich in soy appears to decrease inflammation-induced pain in rats,
according to a study by Johns Hopkins researchers.
Hopkins Bioethics Institute Receives $9.9 Million
from Pew Trusts to Establish Genetics and
Public Policy Center in Washington|
The Phoebe R. Berman Bioethics Institute at The Johns Hopkins University
has received a three-year, $9.9 million grant from the Pew Charitable Trusts
to establish the Genetics and Public Policy Center in Washington, D.C. The
center's first initiative will focus on ethical and public policy issues
related to genetics and human reproduction.
Hopkins Researchers Find Eye Drops Preferable to Eye Patch in Treating Children's
Researchers at Johns Hopkins and 54 eye-care centers across North America
have found two competing methods of correcting a mild form of children's
amblyopia -- pejoratively called "lazy eye"-- are equally effective
in correcting the vision disorder.
At Square One' To Find Culprit In Familial ALS|
After almost 10 years of research with cells and animals to learn what makes
a certain enzyme act as a "bad guy" in the progressive and fatal disease
amyotrophic lateral sclerosis (ALS), Johns Hopkins scientists report that a
leading candidate -- copper -- is off the hook.
Physician-Assisted Suicide or Physician-Assisted Dying: Who Decides?|
The recent decision by U.S. Attorney General John Ashcroft to challenge the
legality of Oregon's physician-assisted suicide law has re-ignited debate over
this thorny issue. Under Oregon's Death With Dignity Act, doctors can prescribe
lethal medications to mentally competent patients with less than six months
to live, as long as strict guidelines are followed. In response to the fallout
after Ashcroft's decision, the Phoebe R. Berman Bioethics Institute at Johns
Hopkins will sponsor a two-part debate about whether the Oregon law should be
allowed to stand, as part of the Harvey M. Meyerhoff Lectures on Ethics and
the End of Life.
Defective Bronchoscopes Identified as Probable Cause of Infections Are Part of Manufacturer's National Recall|
Johns Hopkins has initiated an aggressive campaign to contact all of its
patients who may have been exposed to bacteria due to defective bronchoscopes
that are part of a national recall by the manufacturer. The patients, all
adults, are being offered free evaluation and testing, and they and their
physicians are being asked to be especially alert to symptoms of infection,
such as fever, coughing, increased phlegm (sputum) or increased shortness
of breath. At the same time, Hopkins physicians are trying to heighten awareness
among their colleagues nationwide of this problem and of more aggressive
measures that need to be taken to confirm the source of infection.
Experimental Treatment for Hayfever Is Safe, Effective, and Fast|
Instead of years of allergy shots that may only marginally reduce their symptoms,
"hayfever" victims may soon be closer to getting substantially more
effective control of their allergic problems with just six shots in six weeks.
Hopkins Medicine Appoints Assistant Dean for Admissions, Financial Aid|
Paul T. White, J.D., has been appointed Assistant Dean for Admissions and
Aid at the Johns Hopkins School of Medicine. This new position combines
of admissions --a post White already held --; with the financial needs
of students, two vital steps in the process leading to matriculation.
Hopkins Launches Comprehensive, Multilingual Digestive Diseases Web Resource|
Patients and physicians with questions about digestive diseases can turn
to the newly launched Johns Hopkins Gastroenterology and Hepatology Resource
Center, www.hopkins-gi.org, for
Cognitive Testing Reduces Risks of Procedure for Brain Arteriovenous Malformations|
magine dropping a bowl of spaghetti. That's what AVMs (arteriovenous malformations)
look like in the brain -- dense clusters of twisting and turning blood vessels
that look more like a wrestling match among a hundred small snakes than part
of the circulatory system. Many patients don't know they have one. Some have
crippling headaches. For the more unfortunate, the AVM ruptures, causing brain
damage or death.
Hopkins Physicians Find Hidden Tumors In Rare Bone Disease|
People with the rare bone disease oncogenic osteomalacia have the worst
of both worlds. It may take years before their condition marked by
tiny, noncancerous tumors that hide out and wreak havoc on the skeletal
system is correctly diagnosed. Then more years can go by before physicians
can precisely locate the tumors and remove them. Meanwhile, patients suffer
debilitating bone pain, fractures and muscle weakness.
Johns Hopkins, Maryland Public Television and Local Film Company Showcase Medicine,
Role Modeling to 280 Baltimore High Schoolers |
Through the story of an unsung African-American hero of medicine whose work
led to numerous advances in cardiac surgery, a Johns Hopkins cardiac surgeon
and a Washington film company are encouraging more minority students to
enter health and science careers.
Gene Influences Fat Storage in Mice; May Be Target To Prevent or Treat Obesity
For mice genetically altered to get fat, knocking out a particular gene
keeps them both leaner and healthier, Johns Hopkins School of Medicine scientists
report in the March 1 issue of the Journal of Clinical Investigation.
Cell Type Seems To Control Internal Clock and Pupil of Eye|
Using genetically engineered mice, Johns Hopkins and other scientists have
shown for the first time that a single kind of cell in the retina seems to detect
light for the body's internal clock and for the pupil, they report in a recent
issue of Science.
Lean Mice Adjust to Appetite Suppressant Quickly, Fat Mice Don't|
Expanding their studies of an experimental compound that causes dramatic
weight loss and appetite suppression in mice, Johns Hopkins researchers
now report that lean mice rapidly adjust to daily doses of the drug and
get their appetites back, while their obese counterparts do not.
DePaulo New Director of Psychiatry at Hopkins|
J. Raymond DePaulo, Jr., M.D., a world-renowned expert in the study and
of mood disorders, will be the new Henry Phipps Professor and Director of
Department of Psychiatry and Behavioral Sciences at Johns Hopkins, as of
15, 2002. He replaces Paul McHugh, M.D., who led the department for a quarter
Hypoglycemia May Affect Newborn's Brain Cell Function, Says Hopkins Researcher|
Hypoglycemia, or low blood sugar, may have a significant effect on activity
patterns in a newborn's brain, say researchers at Johns Hopkins Children's
Center and St. Christopher's Hospital for Children in Philadelphia. Their
study of piglet brains, which are metabolically and structurally close to
that of humans, is reported in this month's Brain Research.
Heather Molnar Appointed Web Center Director for JHM|
Heather Molnar has been appointed Web Center director for Johns Hopkins Medicine.
In this role, she is responsible for developing and directing the implementation
of a new Web portal serving the many Johns Hopkins Medicine audiences.
Mistrust, Religious Beliefs Hinder Blood and Organ Donations|
Persistent mistrust of doctors and hospitals, and religious misconceptions
may explain why more people, especially minorities, do not become blood
and organ donors, Johns Hopkins researchers report.
Protein Found That Turns Off Systemic Inflammation in Mice|
In experiments with genetically engineered mice, Johns Hopkins researchers
have found an "off-switch" for systemic inflammation, the body's
overall response to injury and infection. The findings may have implications
for treatment of inflammation-related diseases in humans, from autoimmune
disorders to atherosclerosis, the researchers say.
Exercise Delay Onset of Type 2 Diabetes|
Millions of Americans at high risk for type 2 diabetes can dramatically
lower their chances of getting the disease through diet and exercise, according
to a nationwide study at Johns Hopkins and 26 other medical centers.
Hopkins Launches Minimally Invasive Surgical Training Center|
Johns Hopkins' Department of Surgery has opened a training laboratory for
today's surgeons to learn and perfect the minimally invasive techniques
Stool Test for Colon Cancer Reported by Kimmel Cancer Center at Johns Hopkins|
Scientists at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins*
have developed a safe and reliable stool test that can detect the earliest,
curable stages of colon cancer. Early studies of the test, which uses a
newly developed technology to detect and highlight a key genetic marker
of the disease, are reported in the January 31, 2002, issue of the New England
Journal of Medicine, and are the culmination of more than a decade of effort
to uncover disease mutations and apply them to screening and early detection.
John M. Lazarou Joins Public Affairs and Communications Staff at Johns Hopkins|
John M. Lazarou, a former journalist and public radio talk show host has
joined the media relations staff at Johns Hopkins Medicine's Office of Communications
and Public Affairs. Lazarou comes to Hopkins after two years at Weber Shandwick
Worldwide, a public relations agency, where he practiced media relations.
New Transgenic Rat Model of ALS Expands Research Possibilities|
A team of scientists led by drug maker Wyeth-Ayerst and Johns Hopkins have
engineered and tested a new rat model of Lou Gehrig's disease they say is
far easier to work with than earlier mouse models.
Race Influences Outcome of Liver Transplants, According to Hopkins Study|
African Americans and Asians have a worse outcome than white Americans and
Hispanics after liver transplantation, both in terms of graft rejection
and survival, according to a new Hopkins-led study reported in the Jan.
26 issue of The Lancet.
Babies Born With Penis Developmental Disorder Happier When Raised Male, Say Johns Hopkins Researchers|
Genetically and physically, male babies born with a condition called "micropenis"
are more likely to achieve psychological and sexual well-being in adulthood
if raised male, according to a new study by researchers at Johns Hopkins
and three other centers. Their report in this month's Hormone Research is
the first comprehensive, long-term study examining psychological and sexual
outcomes for both men and women
Hopkins Scientists Identify Molecular Details of Water Transport in the Lung|
We may sputter and gasp when our drink goes down the wrong pipe, but fluid
is vital to a healthy lung. The crucial movement of water across cell membranes
in the lung was long thought to be a passive process, but a team of researchers
from Hopkins and the University of Aarhus in Denmark have demonstrated that
a specific protein plays a major role. The discovery may lead to new treatments
for some forms of asthma, pneumonia and pulmonary edema or swelling.
Blood Markers May Reflect Newborns' Potential of Contracting HIV|
Preventing HIV-infected pregnant women from transmitting the virus to their
newborns has long been a major concern for obstetricians. As such, many
doctors continue to debate the benefits of elective Caesarian section as
a way to protect the infant. In high-risk pregnancies, where the viral loads
can't be suppressed with medication, delivering a baby by C-section directly
from the protected, sterile environment of the amniotic sac can limit the
risk of HIV transmission. But in lower-risk pregnancies, where antiretroviral
medications keep the virus in check, the risk of transmitting HIV to a newborn
is only about 1 percent to 2 percent.
Thyroid Disease Raises Risk For Birth Defects|
Women with thyroid disease are more likely to give birth to babies with
heart, brain and kidney defects even if the thyroid function tests are normal
during the pregnancy, according to new research from Johns Hopkins.
Hopkins Scientist Appointed to President Bush's Council on Bioethics|
President Bush has appointed Hopkins psychiatrist Paul R. McHugh, M.D.,
to be one of 18 members to serve on the President's Council on Bioethics.
The council, created by executive order of President Bush late last year,
will advise the President on ethical and social issues related to biomedical
and other areas of scientific research.
"Brain Pacemaker" for Parkinson's Disease|
The U.S. Food and Drug Administration yesterday announced its approval of
brain stimulation therapy to relieve some of the debilitating symptoms of
Parkinson's Disease, a progressive and degenerative movement disorder. An
estimated one million Americans have Parkinson's Disease, and the new therapy
is intended to complement treatment of the 100,000 patients in advanced
stages whose symptoms are not adequately controlled by medications.
Common Variation of "Klotho" Gene Associated With Human Life Expectancy|
"Klotho," a gene named for the Greek Fate purported to spin the
thread of life, contributes to life expectancy in humans, according to a
team led by Johns Hopkins scientists who report their findings in the Jan.
15 online version of the Proceedings of the National Academy of Sciences.
Fly Cells On The Move May Reveal Clues To Cancer Metastases|
Using neat genetic tricks with fruit flies, scientists from Johns Hopkins
School of Medicine have found the key signal that allows a group of normally
stationary cells in the ovary to travel, they report in the the Dec. 28 issue
Discovery That Common Mood Disorders Are Inherited Together May Reveal Genetic Underpinnings|
The genetic underpinnings of panic disorder and manic depressive (bipolar)
illness have long eluded scientists. Now, researchers at Johns Hopkins studying
the inheritance patterns of these conditions have concluded that they probably
are not separate diseases at all, but different forms of a shared and complex
Basis of Rare Genetic Illness Leads To Better Understanding of Bone Formation,
Hopkins Researchers Find|
Scientists at Johns Hopkins and three other centers have found that defects
in GNAS1, a hormone sensitivity gene, are responsible for progressive osseus
heteroplasia (POH), a disease that causes rice-size bone fragments to spontaneously
form under the skin and inside internal organs. The finding, reported in
week's New England Journal of Medicine, also represents a major step forward
in identifying the genes responsible for normal bone formation in children
adults, a process that has largely mystified scientists.
Experimental Appetite Suppressant Affects Numerous Brain Messengers In Mice|
Johns Hopkins scientists report success in figuring out how an experimental
compound prevents mice from recognizing that it's time to eat, profoundly
suppressing appetite and causing weight loss.
Blood Stem Cells Carry Targeted Genes|
Researchers at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins*
have genetically altered human blood stem cells to selectively activate
genes in developing immune cells. Results of the research in mice, published
in the January 15 issue of Blood, shows it's possible to transfer genes
into stem cells and activate the immune system to fight cancer and enhance
Coretta Scott King Comes to Hopkins|
For the 20th year, Johns Hopkins will remember and honor civil rights leader
Martin Luther King, Jr., with tributes, music and community service awards.
This year's event takes place at noon, Jan. 11 in Turner Auditorium (720
Rutland Ave.), and features civil rights activist Coretta Scott King, widow
of the late Rev. Dr. King Jr. as keynote speaker.
Gives $1.8 Million for Biomedical Research, Training|
The W.M. Keck Foundation has awarded $1.8 million to The Johns Hopkins University
to create the W.M. Keck Center for the Rational Design of Biologically Active
Molecules at the university's School of Medicine. The funding will support
the design and application of synthetic molecules for biomedical research
Wahl Named "Distinguished Scientist" By Academy of Molecular Imaging|
Richard L. Wahl, M.D., professor of radiology and director of nuclear medicine
in Johns Hopkins Medicine's Department of Radiology, was named the Academy
of Molecular Imaging (AMI) Scientist of the Year at the academy's 2001 annual
conference. The award includes a $10,000 prize.