NAME AND TITLE
Joseph Califano, MD
Professor - Otolaryngology - Head & Neck Surgery and Head and Neck Research Division

PHONE
Office - 410-955-6420
Clinical - 443-849-8940

EDUCATION - Medical School
Harvard Medical School, Boston , MA

EDUCATION - Residency
The Johns Hopkins University

EDUCATION - Fellowship
Memorial Sloan-Kettering Cancer Center

BOARD CERTIFICATION
American Board of Otolaryngology

CLINICAL INTERESTS
Tumors of the oral cavity, larynx, pharynx, neck, skull base, salivary glands, thyroid cancer, premalignant conditions of the upper aerodigestive tract, and unknown primary head and neck squamous cell carcinoma, Skin cancer and melanoma

RESEARCH INTERESTS
Molecular biologic basis of head and neck cancer and premalignant lesions, including chromosomal instability, genetic alterations in premalignant lesions, and molecular detection and surveillance. See the Division of Head and Neck Cancer for more research information.

ADMINISTRATIVE TITLE
Professor

PRINCIPAL HOSPITAL
Johns Hopkins Hospital AND
Greater Baltimore Medical Center

SELECTED PUBLICATIONS
selected publications from over 100 publications

Carvalho AL, Chuang A, Jiang WW, Lee J, Begum S, Poeta L, Zhao M, Jerónimo C, Henrique R, Nayak CS, Park HL, Brait MRO, Liu C, Zhou S,
Koch W, Fazio VM, Ratovitski E, Trink B, Westra WH, Sidransky D, Moon C, Califano JA. DCC is a putative conditional tumor suppressor gene inactivated by promoter hypermethylation in head and neck squamous cell carcinoma. Cancer Res. 2006; Oct 1;66(19):9401-7

Zhou S, Kachhap S, Sun W, Wu G, Chuang A, Poeta L, Grumbine L, Mithani SK, Chatterjee A, Koch W, Westra WH, Maitra A, Glazer C, Carducci M, Sidransky D, McFate T, Verma A, Califano JA. Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck. Proc Natl Acad Sci U S A. 2007; May
1;104(18):7540-5 Epub 2007 Apr 24

Mithani SK, Smith IM, Zhou S, Gray A, Koch WM, Maitra A, Califano JA. Mitochondrial resequencing arrays detect tumor-specific mutations in
salivary rinses of patients with head and neck cancer. Clin Cancer Res. 2007 Dec 15;13(24):7335-40.

Chuang AY, Chuang TC, Chang S, Zhou S, Begum S, Westra WH, Ha PK, Koch WM,Califano JA. Presence of HPV DNA in convalescent salivary rinses is an adverse prognostic marker in head and neck squamous cell carcinoma. Oral Oncol. 2008 Mar 6

Mithani SK, Smith IM, Topalian SL, Califano JA. Nonsynonymous somatic mitochondrial mutations occur in the majority of cutaneous
melanomas.Melanoma Res. 2008 Jun;18(3):214-9.