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Infectious Disease Center for Viral Hepatitis


The Center has extensive programs in basic research related to hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, including:



Research Focus

  • Clinical Research


  • Clinical trials of interferon-based and small-molecule therapy for HCV infection
  • Epidemiology
  • Pathogenesis


  • Determinants of the progression of liver disease during chronic HCV infection
  • Pathogenesis of HIV-HCV coinfection
  • Human Genetics
  • HIV/HBV Coinfection


  • Human genetic variation affecting the outcomes of HBV and HCV infections
  • Treatment and virology of HBV and HIV coinfection
  • Immunology (Cellular)


  • Cellular immune responses to HCV during acute and chronic infection
  • Mechanisms of cellular immune failure during the transition from acute to chronic infection
  • Immunology (Innate)
  • Hepatic Inflammation


  • Microbial translocation and Kupffer cells in HIV-HCV coinfection
  • In situ liver studies of HIV-HCV pathogenesis
  • Virology / Evolution
  • Immunology (humoral)


  • Evolution and immune evasion of the HCV genome during acute and chronic infection
  • Determinants of neutralization of HCV by antibodies


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