(updated 5/03/2013)
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(Presented at the 29th Annual Clinical Virology Symposium, Daytona Beach, FL, April 28 - May 1, 2013)
Performance of a New Rapid Real-Time PCR Test for Chlamydia trachomatis and Neisseria gonorrhoeae Which Can Be Used to Provide Results for Patients While in a Clinical Setting
Charlotte A. Gaydos, Barbara Van Der Pol, Mary Jett-Goheen, Mathilda Barnes, Nicole Quinn, Carey Clark, Grace Daniel, Paula Dixon, Edward W. Hook III
Conclusions: The GeneXpert® System is a rapid, self-contained, automated platform for CT/NG testing that demonstrated excellent sensitivities and specificities in symptomatic and asymptomatic women and men. The Xpert assay can provide results to guide treatment decisions before patients leave the doctors office, clinic, emergency department, or in many other settings, such as potentially even a pharmacy.
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(Presented at the 29th Annual Clinical Virology Symposium, Daytona Beach, FL, April 28 - May 1, 2013)
Performance of a New Amplified DNA Assay on the BD ViperTM System in Extracted Mode for the Detection of Trichomonas vaginalis in Women from Cervical, Vaginal, and Urine Specimens.
Charlotte A. Gaydos, J.A. Williams, N. Quinn, L. Eddleman, D. Fuller, S. Taylor, J. Schwebke, J. Lebed, B. Smith, B. Body, M. Nye, B. Van Der Pol
Conclusion: This study provided evidence for adoption and use of new diagnostic options by laboratories and indicated better performance of amplified testing for detection of trichomonas compared to older type tests.
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(Presented at 2012 National Summit on HIV and Viral Hepatitis Diagnosis, Prevention, and Access to Care, Washington DC, November 26-28, 2012)
Self-testing in the Emergency Department (ED) by Kiosk
Gaydos C, Solis M, Hsieh Y-H, Nour S, Jett-Goheen M, Rothman R
Conclusions: Kiosk initiated testing proved to be highly feasible, acceptable, and accurate method of conducting rapid HIV self-testing in this pilot study; however, rates of engagement were only moderate, with almost half of patients volunteering to perform an HIV test....
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(Presented at 2012 National Summit on HIV and Viral Hepatitis Diagnosis, Prevention, and Access to Care, Washington DC, November 26-28, 2012)
Kiosk-Facilitated Patient Self Testing for HIV in an Emergency Department Rapid HIV Screening Program
Yu-Hsiang Hsieh, Megan Gauvey-Kern, Charlotte Gaydos, Alonzo Woodfield, Stephen Peterson, Richard Rothman
Conclusions: This is the first demonstration of kiosks for engaging patients and guiding HIV self-testing in a health care setting. Notably, while rates of agreement for self-testing were similar to facilitator testing, more than half of patients declined to perform their own test; further, a substantial number of patients needed assistance from staff or failed to complete self-testing....
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(Presented at 2012 National Summit on HIV and Viral Hepatitis Diagnosis, Prevention, and Access to Care, Washington DC, November 26-28, 2012)
Novel Emergency Department Registration Kiosk for HIV Screening Increases Engagement of High Risk Patients
Yu-Hsiang Hsieh, Megan Gauvey-Kern, Alonzo Woodfield, Stephen Paterson, Lan Wu, Charlotte Gaydos, Richard Rothman
Conclusions: Streamlined upfront HIV screening via kiosk resulted in increased rates of HIV test offering and comparable testing completion rates relative to the bedside testing method. Patients rated kiosk-based approach as highly acceptable....
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(Presented at American Public Health Association 140th Annual Meeting & Exposition, San Francisco, CA, October 27-31, 2012)
So They Can Know: A description and initial evaluation of a new email-based STI partner notification service
Jessica Ladd
Overview: So They Can Know is a website designed to increase rates of partner notificationfor sexually transmitted infections (STIs). The website provides information on partner notification and allows users to anonymously email their sex partners. This poster describes the process behind the creation and planned evaluation of So They Can Know, in the hopes that it might inform the creation and evaluation of evidence-based public health innovations, particularly websites, in the future.
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(Presented at International Union against Sexually Transmitted Infections World Congress 2012, Melbourne, Australia, October 15-17, 2012)
Microwave-Accelerated Metal-Enhanced Fluorescence (MAMEF) Point of Care Test for the Detection of Chlamydia trachomatis
Gaydos CA, Melendez JH, Jett-Goheen M, Huppert J, Geddes CD
Conclusions: The CT MAMEF assay demonstrated high sensitivity and specificity when using vaginal samples transported as dry swabs. MAMEF platform is a significant step forward in the development of a point of care test for CT.
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(Presented at International Union against Sexually Transmitted Infections World Congress 2012, Melbourne, Australia, October 15-17, 2012)
Optimization and Clinical Testing of a Microwave-Accelerated Metal-Enhanced Fluorescence (MAMEF) Assay for the Detection of Chlamydia trachomatis
Melendez JH, Gaydos CA, Geddes CD
Conclusions: Cell lysis and DNA fragmentation is achieved in 30 seconds, and gold and aluminum lysing triangles are equally effective. Dry vaginal swabs are an effective collection method and sensitivity of the MAMEF assay is very high using dry swabs rehydrated in water. Rapid lysis of bacterial cells, fragmentation and detection of genomic DNA can be carried out in less than 10 minutes.
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(Presented at Next Generation Dx Summit, Washington, DC, August 21-23, 2012)
Johns Hopkins University Center for Sexually Transmitted Diseases Point of Care Tests (POCT): A One Stop Shop for Facilitating POCT Development
Charlotte Gaydos, Mary Jett-Goheen, Terry Hogan, Yu-Hsiang Hsieh, Anne Rompalo, Joany Jackman
Conclusion: There is a disconnect between industry and clinicians regarding the perceived barriers to POCT test development and ultimately acceptance. It is possible to achieve the most realistic test by allowing users to make trade offs on test attributes but not test characteristics.
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(Presented at "AIDS 2012" - the XIX International AIDS Conference, Washington, DC, July 22-27, 2012)
Costs and Effectiveness of Neonatal Male Circumcision in the United States
Seema Kacker, Kevin Frick, Charlotte Gaydos, Aaron Tobian
Conclusion: Continued declines in male circumcision rates associated with increased infection prevalence, thereby increasing medical expenditures for men and women.
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[Presented at the British Association for Sexual Health and HIV (BASHH) 2012 Spring Meeting (jointly held with the ASTDA), June 27-29, 2012, Brighton, Dome, UK]
Yearly trends for the Internet recruitment program, www.iwantthekit.org - What happened to the STI prevalence?
CA Gaydos, M Barnes, YH Hsieh, M Jett-Goheen, N Quinn, P Whittle, T Hogan
Objective: To determine significance in trends for STIs for the female and male population accessing screening over time....
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(Presented at the Society for Academic Emergency Medicine Annual Meeting, Chicago, Illinois, May 9-12, 2012)
Novel Approach to Streamlining HIV Testing in the Emergency Department - Touch-Screen Kiosk Systems for Offering HIV Test and Risk Assessment
Yu-Hsiang Hsieh, Megan Gauvey-Kern, Alonzo Woodfield, Stephen Peterson, Lan Wu, Charlotte Gaydos, Richard Rothman
Objective: To evaluate the feasibility and perceived acceptability of kiosks for offering HIV testing and gathering relevant demographic and risk information from ED patients.
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(Presented at the 2012 CDC National STD Prevention Conference, Minneapolis, MN, March 12-15, 2012)
Driving Point of Care Technology Development: An integrated approach to consensus building using DCE and facilitated meetings
Joany Jackman, Mary Jett-Goheen, Terry Hogan, Yu-Hsiang Hsieh, Anne Rompalo, Charlotte Gaydos
Conclusion: We have described a new methodology for evaluating diagnostic technology requirements for Chlamydia POCT. This methodology integrates the use of force choice surveys constructed and analyzed using design of experiments approaches and the use of a facilitated meeting format comprising both oral and electronic discussions...
►► View PDF of poster here.
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(Presented at the 2012 CDC National STD Prevention Conference, Minneapolis, MN, March 12-15, 2012)
Performance of a Point-of-Care Device to Detect Herpes Simplex Virus
Jill Huppert, Elizabeth Hesse, Molly Bernard, Mary Jett-Goheen, Justin Hardick, Charlotte Gaydos
Conclusion: In this small pilot sample, the POC HSV device shows promise but seemed to perform better in the laboratory than at the bedside...
►► View PDF of poster here.
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(Presented at the 2012 CDC National STD Prevention Conference, Minneapolis, MN, March 12-15, 2012)
Women Who Use the "I Want the Kit" Internet Site to Test for Chlamydia and Gonorrhea: What Does Where They Live Tell Us about Them?
Ravikiran Muvva, Angeli Bueno, Yu-Hsiang Hsieh, Terry Hogan, Charlotte Gaydos
Conclusion: The census block groups (CBGs) from which kits were requested were more likely to have a population below poverty, and have lower rates of home ownership. CBGs with kit requests had a higher percent of black female population and had higher chlamydia rates...
►► View PDF of poster here.
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(Presented at the 2012 CDC National STD Prevention Conference, Minneapolis, MN, March 12-15, 2012)
Use of Social Marketing During GYT: Get Yourself Tested Campaign to Increase Chlamydia trachomatis Screening via an Internet Recruitment
Mary Jett-Goheen, Mathilda Barnes, Nicole Quinn, Charlotte Gaydos
Conclusion: The successful use of social marketing techniques appeared to increase testing via Internet recruitment as website hits, kit requests, and kits returned for testing all increased during the period of the GYT campaign...
►► View PDF of poster here.
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(Presented at the 2012 CDC National STD Prevention Conference, Minneapolis, MN, March 12-15, 2012)
Streamlining HIV Testing in the Emergency Department - Leveraging Kiosks to Provide True Universal Screening
Megan Gauvey-Kern, Richard Rothman, Alonzo Woodfield, Stephen Peterson, Boris Tizenberg, Joseph Kennedy, Charlotte Gaydos, Yu-Hsiang Hsieh
Conclusion: ED patients' response to the kiosk system was overwhelmingly favorable... Findings indicate significant potential for kiosk-based public health programs to provide true universal screening in the ED...
►► View PDF of poster here.
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(Presented at the 2012 CDC National STD Prevention Conference, Minneapolis, MN, March 12-15, 2012)
I Want the Kit: At-Home STD Testing in Urban & Rural Alaska
Brenna Simons, Cornelia Jessen, Lisa Rea, Mathilda Barnes, Perry Barnes, Charlotte Gaydos
Background: The Alaska Native Tribal Health Consortium (ANTHC) partnered with the "I Want the Kit" program (IWTK) at Johns Hopkins University (JHU) to provide at-home STD testing to all Alaskans starting August 1st, 2011. ANTHC is the first tribal health entity to partner with IWTK at JHU. This project is made possible through funding from the IHS STD Program and CDC.
►► View PDF of poster here.
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(Presented at the 2012 CDC National STD Prevention Conference, Minneapolis, MN, March 12-15, 2012)
Acceptability of Innovative Methods of Anonymous STI Partner Notification Among American Adolescents
Jessica Ladd, Charlotte Gaydos
Objectives: What is the acceptability of various anonymous Partner Notification (PN) methods? Are some PN methods more acceptable than others? What is the feasibility of various anonymous PN methods?...
►► View PDF of poster here.
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