About the Center

The Center for Infection and Inflammation Imaging Research is an interdisciplinary center with broad goals mainly focusing on the diagnosis, treatment and monitoring of infectious and inflammatory processes. This center draws upon expertise throughout Johns Hopkins University School of Medicine, including Infectious Diseases investigators in Pediatrics and Medicine, Radiology, Oncology and collaborators at the Center for Imaging Science who help with the development of advanced imaging tools. Infectious Diseases and Radiology currently have significant ongoing collaborations that focus on developing novel methods for directly imaging Mycobacterium tuberculosis, inflammation associated with TB and monitoring their response to treatment. These initial collaborations have led to the award of several grants and publications. Although this center will primarily have a preclinical focus, due mainly to extensive yet evolving infrastructure for small animal imaging, clinical infection and inflammation imaging studies will also be conducted in the future.

In conjunction with the BRB Molecular Imaging Center, the Center for Infection and Inflammation Imaging Research is also a core Molecular Imaging facility and provides state-of-the art small animal imaging equipment, including PET, SPECT, CT and US, to support the wide range of scientific projects within the diverse research community of the Johns Hopkins University and beyond.

Director

Sanjay K Jain, MD
Associate Professor, Department of Pediatrics

Co-Directors

William R Bishai, MD, PhD
Professor, Department of Medicine

Martin G Pomper, MD, PhD
Professor, Department of Radiology

Faculty In-charge

Sanjay K Jain, MD
Department of Pediatrics
Email: sjain5@jhmi.edu

Fellows

Edward A. Weinstein, MD, PhD
Department of Medicine

Alvaro Ordonez, MD
Department of Pediatrics

Trained technologist

Mariah Weir

Collaborators at Center for Imaging Science

Bruno Jedynak, PhD
Department of Applied Mathematics and Statistics

Publications

• Foss CA, Harper JS, Wang H, Pomper MG, Jain SK. Non-Invasive Molecular Imaging of Tuberculosis-Associated Inflammation with Radioiodinated DPA-713 J Infect Dis. 2013 (in press).
• Weinstein EA, Liu L, Ordonez AA, Wang H, Hooker JM, Tonge PJ, Jain SK. Noninvasive Determination of 2-[18F]-Fluoroisonicotinicacid hydrazide Pharmacokinetics by Positron Emission Tomography in Mycobacterium tuberculosis Infected Mice. Antimicrob Agents Chemother. 2012 Sep 24. .
• Skerry C, Harper J, Weir M, Bishai WR, Jain SK. Adjunctive TNF inhibition with standard treatment enhances bacterial clearance in a murine model of necrotic TB granulomas. PLoS ONE 7(6): e39680.
• Everton KL, Mazal J, Mollura DJ, for RAD-AID Conference Writing Group*. White Paper Report of the 2011 RAD-AID Conference on International Radiology for Developing Countries: Integrating Multidisciplinary Strategies for Imaging Services in the Developing World. J Am Coll Radiol 2012;9:488-494.
• Be NA, Bishai WR, Jain SK. Role of Mycobacterium tuberculosis pknD in the Pathogenesis of Central Nervous System Tuberculosis. BMC Microbiol. 2012, 12:7. Highly accessed.
• Harper J, Skerry C, Davis SL, Tasneen R, Weir W, Kramnik I, Bishai WR, Pomper MG, Nuermberger EL, Jain SK. Mouse model of necrotic TB granulomas develops hypoxic lesions. J Infect Dis. 2012 Feb;205(4):595-602. Epub 2011 Dec 23.
• Vidal C, Beggs D, Younes L, Jain SK, Jedynak B. Incorporating user input in template-based segmentation. Proceedings of the IEEE International Symposium on Biomedical Images 2011.
• Davis SL, Nuermberger EL, Um P, Vidal C, Jedynak B, Pomper MG, Bishai WR, Jain SK. Monitoring response to TB drug treatment using [18F]-2-fluoro-deoxy-D-glucose positron emission tomography. Antimicrob Agents Chemother. 2009 Nov;53(11):4879-84.
• Davis SL, Be NA, Lamichhane G, Nimmagadda S, Pomper MG, Bishai WR, Jain SK. Bacterial thymidine kinase as a non-invasive imaging reporter for Mycobacterium tuberculosis in live animals. PLoS ONE 2009 4(7): e6297.
• Vidal C, Hewitt J, Davis S, Younes L, Jain S, Jedynak B. Template Registration with missing parts: Application to the Segmentation of Tuberculosis infected lungs. Proceedings of the IEEE International Symposium on Biomedical Images 2009:718-721.
• Jain SK, Lamichhane G, Nimmagadda S, Pomper M, Bishai WR. Antibiotic Treatment of Tuberculosis: Old Problems, New Solutions. Microbe 2008 Jun; 3(6): 285-92.

Please contact us with any questions or concerns at 410-614-9501.