Email:
nickbe@gmail.com
Tuberculosis of the central nervous system (CNS) is a serious, often fatal disease primarily affecting young children. It is believed to develop after hematogenous dissemination and subsequent invasion of the CNS by Mycobacterium tuberculosis. We have developed a screen for identifying M. tuberculosis genes involved in CNS tuberculosis pathogenesis. One set of genes identified and under study is the Rv0986-Rv0988 operon of M. tuberculosis. This operon is believed to be involved in attachment and entry into host cells. Evaluation of these genes and identification of others will help in understanding the microbial and host processes involved in CNS TB.
Vancouver, B.C., Keystone Meeting |
Publications:
Be NA, Kim KS, Bishai WR, Jain SK. Pathogenesis of Central Nervous System Tuberculosis. Curr Mol Med 2009;9(2):94-99.
Be NA, Lamichhane G, Grosset J, Tyagi S, Cheng QJ, Kim KS, Bishai WR, Jain SK. Murine Model to Study Invasion and Survival of Mycobacterium tuberculosis in the Central Nervous System. J Infect Dis 2008;198:1520-1528.
