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Tuberculosis of the central nervous system (CNS) is a serious, often fatal disease primarily affecting young children. It is believed to develop after hematogenous dissemination and subsequent invasion of the CNS by Mycobacterium tuberculosis. We have developed a screen for identifying M. tuberculosis genes involved in CNS tuberculosis pathogenesis. One set of genes identified and under study is the Rv0986-Rv0988 operon of M. tuberculosis. This operon is believed to be involved in attachment and entry into host cells. Evaluation of these genes and identification of others will help in understanding the microbial and host processes involved in CNS TB.
Vancouver, B.C., Keystone Meeting
Be NA, Kim KS, Bishai WR, Jain SK. Pathogenesis of Central Nervous System Tuberculosis. Curr Mol Med 2009;9(2):94-99.
Be NA, Lamichhane G, Grosset J, Tyagi S, Cheng QJ, Kim KS, Bishai WR, Jain SK. Murine Model to Study Invasion and Survival of Mycobacterium tuberculosis in the Central Nervous System. J Infect Dis 2008;198:1520-1528.
Dutta NK, Mehra S, Didier PJ, Roy CJ, Doyle LA, Alvarez X, Ratterree M, Be NA, Lamichhane G, Jain SK, Lacey MR, Lackner AA, Kaushal, D. Genetic Requirements for the Survival of Tubercle Bacilli in Primates. J Infect Dis 2010;201(11):1743-52.
Be NA, Jain SK, Bishai WR. Pathogenesis of Tuberculosis: New Insights. In: Raviglione, MC, ed. Tuberculosis, Fourth Edition: The Essentials. Informa Healthcare, 2009: 60-80.
Davis SL, Be NA, Lamichhane G, Nimmagadda S, Pomper MG, Bishai WR, Jain SK. Bacterial thymidine kinase as a non-invasive imaging reporter for Mycobacterium tuberculosis in live animals. PLoS One 2009;4(7):e6297