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Noton K. Dutta, PhD

Noton email: Noton Dutta <ndutta1@jhmi.edu>

Research Interests

I am working on multiple projects focusing on studies characterizing the efficacy of novel drugs and drug combinations against M. tuberculosis (Mtb) in murine and guinea pig models and searching for new anti-TB drug targets, with the goal of shortening the duration of TB chemotherapy. To this end, I am following two different approaches: i) characterization of Mtb transcriptional responses to new anti-TB compounds and use of bioinformatics to identify relevant drug targets; ii) use of multidisciplinary techniques, including computational modeling and high throughput genetic screens in various animal models, in order to elucidate Mtb essential pathways involved in latency and reactivation.

Publications

To read some of these publications online, click here. Please note that to read the full text of some of these articles requires that you have an online subscription to the journal.


  1. Dutta NK, Mehra S, Martinez AN, Alvarez XH, Renner NA, Morici LA, Pahar B, MacLean AG, Lackner AA and Kaushal D. Stress response factor sigH modulates the interaction of Mycobacterium tuberculosis with host phagocytes. PLoSONE 7(1), 2012; e28958. PMCID: PMC3250399
  2. Roy CJ$, Sivasubrahamini S$, Dutta NK$, Mehra S$, Abrahams N, Killeen SZ, Hammoud BE, Talton JD, Didier P, Kaushal D. Aerosolized Gentamicin Reduces the Burden of Tuberculosis in a Murine Model. Antimicrobial Agents and Chemotherapy, 56(2), 2012; 883-886. $ Joint first authors
  3. Dutta NK, Mazumdar K, Dastidar SG, Karakousis PC and Amaral L. New patentable use of an old neuroleptic compound thioridazine to combat tuberculosis: A Gene Regulation Perspective. Recent Patents on Anti-Infective Drug Discovery, 6(2), 2011; 127-137.
  4. Mehra S, Golden NA, Dutta NK, Doyle LA, Asher M, Russell-Lodrigue K, Monjure C, Didier PJ, Roy CJ, Blanchard JL, Veazey RS, Lackner AA, Kaushal D. Reactivation of latent tuberculosis in rhesus macaques by co-infection with simian immunodeficiency virus. Journal of Medical Primatology, 40(4), 2011; 233-243.
  5. Mehra S, Pahar B, Dutta NK, Conerly CN, Falkenstein KP, Alvarez X and Kaushal D. Transcriptional reprogramming in primate tuberculosis granulomas. PLoSONE 5(8), 2010; e12266. PMCID: PMC2930844.
  6. Mazumdar K, Kumar AK and Dutta NK$, Potential role of the cardiovascular non-antibiotic (helper compound) amlodipine in the treatment of microbial infections: scope and hope for the future. International Journal of Antimicrobial Agents 36(4), 2010; 295-302. $ Corresponding author.
  7. Mehra S, Dutta NK, Mollenkopf HJ and Kaushal D. MT2816 encodes a key Mycobacterium tuberculosis stress response factor. Journal of Infectious Diseases 202(6), 2010; 943-953. PMCID: PMC2862080
  8. Dutta NK, Mehra S, Didier PJ, Roy CJ, Doyle L, Alvrrez XH, Ratterree M, Be NA, Lamichhane G, Jain SK, Lacey MR, Lackner AA and Kaushal D. Genetic requirements for the survival of tubercle bacilli in primates. Journal of Infectious Diseases 201(11), 2010; 1743-1752. PMCID: PMC3052882
  9. Dutta NK, Mehra S and Kaushal D. Mycobacterium tuberculosis sigma factor network responds to cell-envelope damage by the promising anti-mycobacterial thioridazine. PLoSONE 5(4), 2010; e10069. PMCID: PMC2851646
  10. DasGupta A, Chaki S, Mukherjee S, Jeyaseeli L, Mazumdar K, Dutta NK, and Dastidar SG: Experimental analyses of synergistic combinations of antibiotics with a recently recognised antibacterial agent lacidipine. European Journal of Clinical Microbiology and Infectious Diseases class="rprtid1"29(2), 2010; 239-243.
  11. Lee HK, Lee BH, Seok SH, Baek MW, Lee HY, Kim DJ, Na YR, Noh KJ, Park SH, Dutta NK, Kariwa H, Nakauchi M, Heo SJ and Park JH: Production of specific antibodies against SARS-coronavirus nucleocapsid protein without cross reactivity with human coronaviruses 229E and OC43. Journal of Veterinary Science 11 (2), 2010; 165-167. PMCID: PMC2873818
  12. Dutta NK, Mazumdar K, DasGupta A and Dastidar SG: Activity of the phenothiazine methdilazine alone or in combination with isoniazid or streptomycin against Mycobacterium tuberculosis in mice. Journal of Medical Microbiology 58, 2009; 1667-1668.
  13. Park SH, Dutta NK$, Baek MW, Kim DJ, Na YR, Seok SH, Lee BH, Cho JE, Cho GS and Park JH: NaCl plus chitosan as a dietary salt to prevent the development of hypertension in spontaneously hypertensive rats. Journal of Veterinary Science 10(2), 2009; 141-146. PMCID: PMC2801110 $Joint first authors.
  14. Mazumdar K, Dastidar SG, Park JH and Dutta NK$: The anti-inflammatory non-antibiotic helper compound diclofenac: an antibacterial drug target. European Journal of Clinical Microbiology and Infectious Diseases 28 (8), 2009; 881-891. $ Corresponding author
  15. Dutta NK, Mazumdar K, DasGupta A and Dastidar SG:In vitro and in vivo efficacies of amlodipine against Listeria monocytogenes. European Journal of Clinical Microbiology and Infectious Diseases 7, 2009; 849-853.
  16. Kim DJ, Seok SH, Baek MW, Lee HY, Na YR, Park SH, Lee HK, Dutta NK, Kawakami K and Park JH: Estrogen-responsive transient expression assay using a brain aromatase based reporter gene in zebrafish (Danio rerio). Comparative Medicine 59(5), 2009; 416-423. PMCID: PMC2771600
  17. Dutta NK, Mazumdar K, Park JH: In vitro synergistic effect of gentamicin with the anti-inflammatory agent diclofenac against Listeria monocytogenes. Letters in Applied Microbiology 48, 2009; 783-785.
  18. Kim DJ, Seok SH, Baek MW, Lee HY, Na YR,  Park SH, Lee HK, Dutta NK, Kawakami K and Park JH: Benomyl induction of brain aromatase and toxic effects in the zebrafish embryo. Journal of Applied Toxicology 29(4), 2009; 289-294.
  19. Kim DJ, Seok SH, Baek MW, Lee HY, Na YR,  Park SH, Lee HK, Dutta NK, Kawakami K and Park JH: Developmental toxicity and brain aromatase induction by high genistein concentrations in zebrafish embryos. Toxicology Mechanisms and Methods 19(3), 2009; 251-256. PMCID: PMC2739649.
  20. Dutta NK, Mazumdar K, Seok SH, Baek MW, Lee HY, Kim DJ, Noh KJ, Na YR, Park SH, Lee HK, Lee BH and Park JH: The antii-inflammatory drug diclofenac retains antilisterial activity in vivo.  Letters in Applied Microbiology 47(2), 2008; 106-111.
  21. Lee HK, Lee BH, Dutta NK, Seok SH, Baek MW, Lee HY, Kim DJ, Na YR, Noh KJ, Park SH, Kariwa H, Mai LQ, Heo SJ and Park JH: Detection of antibodies against SARS-coronavirus using recombinant truncated nucleocapsid proteins by ELISA. Microbiology and Biotechnology 18(10), 2008; 1717-1721.
  22. Dutta NK, Mazumdar K, Lee BH, Baek MW, Kim DJ, Na YR, Park SH, Lee HK, Kariwa H, Mai LQ and Park JH: Search for potential target site of nucleocapsid gene for the design of an epitope based SARS DNA vaccine. Immunology Letters 118(1), 2008; 65-71.
  23. Mishra US, Dutta NK$, Mazumdar K, Mahapatra SK, Chakraborty P and Dastidar SG: Anti-Salmonella activity of a flavonone from Butea frondosa bark in mice. Oriental Pharmacy and Experimental Medicine 8(4), 2008; 339-348. $ Joint first authors
  24. Dutta NK, Mazumdar K, Baek MW, Kim DJ, Noh KJ, Na YR, Park SH, Lee HK, Lee BH and Park JH: In vitro efficacy of diclofenac against Listeria monocytogenes. European Journal of Clinical Microbiology and Infectious Diseases 2(4), 2008; 315-319.
  25. Dutta NK, Mazumdar K, Park JH, Dastidar SG, Kristiansen JE, Molnar J and Amaral L: The potential management of resistant microbial infections with a novel non-antibiotic: the anti-inflammatory drug diclofenac sodium. International Journal of Antimicrobial Agents 30(3), 2007; 242–249.
  26. Dutta NK, Mazumdar K, Dastidar SG and Park JH: Activity of diclofenac used alone and in combination with streptomycin against Mycobacterium tuberculosis in mice. International Journal of Antimicrobial Agents 30(4), 2007; 336-340.
  27. Dutta NK, Mazumdar K, Mishra US, Dastidar SG and Park JH: Isolation and identification of a flavonone from Butea frondosa. Pharmaceutical Chemistry Journal 41(5), 2007; 99-101.
  28. DasGupta A, L Jeyaseeli, Dutta NK, Mazumdar K, Karak P, Dastidar SG, Motohashi N and Shirataki Y: Studies on the antimicrobial potential of the cardiovascular drug lacidipine. In Vivo 21(5), 2007; 847-850.
  29. Na YR, Seok SH, Baek MW, Lee HY, Kim DJ, Noh KJ, Park SH, Lee HK, Dutta NK, Lee BH and Park JH: Enzyme-linked immunosorbent assay to detect the MHV infection in mice. Laboratory Animal Research 22 (4), 2006; 433-435.
  30. Mazumdar K, Dutta NK, Dastidar SG, Motohashi N and Shirataki Y: Effectiveness of the antiinflammatory drug diclofenac in the management of UTI caused by E. coli. In Vivo 20(5), 2006; 613-620.
  31. Pal T, Dutta NK, Mazumdar K, Dasgupta A, Jeyaseeli L and Dastidar SG: Assessment of antibacterial activity of the cardiovascular drug nifedipine. Oriental Pharmacy and Experimental Medicine 6(2), 2006; 126-133.
  32. Dastidar SG, Ganguly K, Mahapatra SK, Dutta NK, Mazumdar K, Chakrabarty AN and Motohashi N: Pronounced inhibitory effect of chlorcyclizine (CCZ) in experimental hepatocarcinoma. In Vivo 20, 2006; 97-102.
  33. Jeyaseeli L, DasGupta A, Kumar KA, Mazumdar K, Dutta NK, and Dastidar SG: Antimicrobial potentiality of thioxanthene fluphenthixol through extensive in vitro and in vivo experiment. International Journal of Antimicrobial Agents 27, 2006; 58-62.
  34. Dutta NK, Mazumdar K, Dastidar SG, Chakrabarty AN, Shirataki Y and Motohashi N: In vitro and in vivo antimycobacterial activity of an antihypertensive agent methyl-L-DOPA. In Vivo 19, 2005; 539-546.
  35. Mazumdar K, Dutta NK, Kumar KA and Dastidar SG: In vitro and in vivo synergism between tetracycline and the cardiovascular agent oxyfedrine HCl against common bacterial strains. Biological & Pharmaceutical Bulletin 28(4), 2005; 713-717.
  36. Basu LR, Mazumdar K, Dutta NK, Karak P and Dastidar SG:  Antibacterial property of the antipsychotic agent prochlorperazine, and its synergism with methdilazine. Microbiological Research 160, 2005; 95-100.
  37. Dutta NK, Dastidar SG, Kumar KA, Mazumdar K, Ray R and Chakrabarty AN: Antimycobacterial activity of the antiinflammatory agent diclofenac sodium, and its synergism with streptomycin. Brazilian Journal of Microbiology 35(4), 2004; 316-323.
  38. Dutta NK, Kumar KA, Mazumdar K, Dastidar SG, Ray R and Chakrabarty AN: In  vitro and in vivo antimycobacterial activity of antiinflammatory drug, diclofenac sodium. Indian Journal of Experimental Biology 42, 2004; 922-927.
  39. Mazumdar K, Dutta NK, Dastidar SG, Motohashi N and Shirataki Y: Phytochemical isoflavones against diabetic foot bacteria. Oriental Pharmacy and Experimental Medicine 4(4), 2004; 261-266.
  40. Dastidar SG, Manna AK, Kumar KA, Mazumdar K, Dutta NK, Chakrabarty AN, Motohashi N and Shirataki Y: Studies on the antibacterial potentiality of isoflavones. International Journal of Antimicrobial Agents 23, 2004; 99-102.
  41. Kumar KA, Mazumdar K, Dutta NK, Karak P, Dastidar SG and Ray R:  Evaluation of synergism between the aminoglycoside antibiotic streptomycin and the cardiovascular agent amlodipine. Biological & Pharmaceutical Bulletin 27(7), 2004; 1116-1120.
  42. Dastidar SG, Annadurai A, Kumar KA, Dutta NK and Chakrabarty AN: Evaluation of a synergistic combination between the non-antibiotic microbicides diclofenac and trifluoperazine. International Journal of Antimicrobial Agents 21(6), 2003; 599-601.
  43. Kumar KA, Ganguly K, Mazumdar K, Dutta NK, Dastidar SG and Chakrabarty AN: Amlodipine: a cardiovascular drug with a powerful antimicrobial property. Acta Microbiologica Polonica 52(3), 2003; 285-292.
  44. Mazumdar K, Ganguly K, Kumar KA, Dutta NK, Chakrabarty AN and Dastidar SG: Antimicrobial potentiality of a new non-antibiotic: the cardiovascular drug oxyfedrine hydrochloride. Microbiological Research 158(3), 2003; 259-264.
  45. Sarkar A, Kumar KA, Dutta NK, Chakraborty P and Dastidar SG: Evaluation of in vitro and in vivo antibacterial activity of dobutamine hydrochloride. Indian Journal of Medical Microbiology 21(3), 2003; 172-178.
  46. Ray R, Das AK, Dutta NK, Chakrabarty AN, Chaudhuri BN, Seth S and Dastidar SG: Potentiality of a new compound for in vitro differentiation between halophilic and non-halophilic vibrios. Indian Journal of Experimental Biology 40, 2002; 220-222.

 

 

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